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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes UMP from orotate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Orotate phosphoribosyltransferase (pyrE)
  2. Orotidine 5'-phosphate decarboxylase (pyrF)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei11SubstrateUniRule annotation1
Binding sitei34SubstrateUniRule annotation1
Active sitei63Proton donorUniRule annotation1
Binding sitei124SubstrateUniRule annotation1
Binding sitei186SubstrateUniRule annotation1
Binding sitei195SubstrateUniRule annotation1
Binding sitei215Substrate; via amide nitrogenUniRule annotation1
Binding sitei216SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPyrimidine biosynthesis

Enzyme and pathway databases

BioCyciLLAC272623:G1FZA-1422-MONOMER
UniPathwayiUPA00070; UER00120

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
Alternative name(s):
OMP decarboxylaseUniRule annotation
Short name:
OMPDCaseUniRule annotation
Short name:
OMPdecaseUniRule annotation
Gene namesi
Name:pyrFUniRule annotation
Ordered Locus Names:LL1345
ORF Names:L181692
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
Proteomesi
  • UP000002196 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001345491 – 237Orotidine 5'-phosphate decarboxylaseAdd BLAST237

Proteomic databases

PaxDbiQ9CFW9
PRIDEiQ9CFW9

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272623.L181692

Structurei

3D structure databases

ProteinModelPortaliQ9CFW9
SMRiQ9CFW9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni61 – 70Substrate bindingUniRule annotation10

Sequence similaritiesi

Belongs to the OMP decarboxylase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4106EG9 Bacteria
COG0284 LUCA
HOGENOMiHOG000226071
KOiK01591
OMAiNFKIFLD

Family and domain databases

Gene3Di3.20.20.70, 1 hit
HAMAPiMF_01200_B OMPdecase_type1_B, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR014732 OMPdecase
IPR018089 OMPdecase_AS
IPR001754 OMPdeCOase_dom
IPR011060 RibuloseP-bd_barrel
PANTHERiPTHR32119:SF2 PTHR32119:SF2, 1 hit
PfamiView protein in Pfam
PF00215 OMPdecase, 1 hit
SMARTiView protein in SMART
SM00934 OMPdecase, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR01740 pyrF, 1 hit
PROSITEiView protein in PROSITE
PS00156 OMPDECASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CFW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQENRPVIAL DFPEFSDVKD FLEKFDPSEQ LYIKLGMELF YTAGPQVVYY
60 70 80 90 100
VKSLGHSVFL DLKLHDIPNT VESSMHVLAR LGVDMVNVHA AGGVEMMVAA
110 120 130 140 150
KRGLEAGTPV GRQRPKLIAV TQLTSTSEEI MQNDQKIMTS LEESVINYAQ
160 170 180 190 200
KTAQAGLDGV VCSAHEVEKI KAATSKEFIC LTPGIRPEGA SKGDQKRVMT
210 220 230
PKEARTIGSD YIVVGRPITQ AKDPVASYHA IKAEWNR
Length:237
Mass (Da):26,106
Last modified:June 1, 2001 - v1
Checksum:iBBAA395B4DE31A9B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti76H → R in AAF63958 (PubMed:10742196).Curated1
Sequence conflicti83V → L in AAF63958 (PubMed:10742196).Curated1
Sequence conflicti129E → K in AAF63958 (PubMed:10742196).Curated1
Sequence conflicti237R → Q in AAF63958 (PubMed:10742196).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF174425 Genomic DNA Translation: AAF63958.1
AE005176 Genomic DNA Translation: AAK05443.1
PIRiA86793
RefSeqiNP_267501.1, NC_002662.1
WP_003131093.1, NC_002662.1

Genome annotation databases

EnsemblBacteriaiAAK05443; AAK05443; L181692
GeneIDi1114995
KEGGilla:L181692
PATRICifig|272623.7.peg.1451

Entry informationi

Entry nameiPYRF_LACLA
AccessioniPrimary (citable) accession number: Q9CFW9
Secondary accession number(s): Q9L9C5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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