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Q9CFW9 (PYRF_LACLA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Gene names
Name:pyrF
Ordered Locus Names:LL1345
ORF Names:L181692
OrganismLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis) [Reference proteome] [HAMAP]
Taxonomic identifier272623 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus

Protein attributes

Sequence length237 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) By similarity. HAMAP-Rule MF_01200

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2. HAMAP-Rule MF_01200

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2. HAMAP-Rule MF_01200

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01200

Sequence similarities

Belongs to the OMP decarboxylase family. Type 1 subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 237237Orotidine 5'-phosphate decarboxylase HAMAP-Rule MF_01200
PRO_0000134549

Regions

Region61 – 7010Substrate binding By similarity

Sites

Active site631Proton donor By similarity
Binding site111Substrate By similarity
Binding site341Substrate By similarity
Binding site1241Substrate By similarity
Binding site1861Substrate By similarity
Binding site1951Substrate By similarity
Binding site2151Substrate; via amide nitrogen By similarity
Binding site2161Substrate By similarity

Experimental info

Sequence conflict761H → R in AAF63958. Ref.1
Sequence conflict831V → L in AAF63958. Ref.1
Sequence conflict1291E → K in AAF63958. Ref.1
Sequence conflict2371R → Q in AAF63958. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9CFW9 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: BBAA395B4DE31A9B

FASTA23726,106
        10         20         30         40         50         60 
MQENRPVIAL DFPEFSDVKD FLEKFDPSEQ LYIKLGMELF YTAGPQVVYY VKSLGHSVFL 

        70         80         90        100        110        120 
DLKLHDIPNT VESSMHVLAR LGVDMVNVHA AGGVEMMVAA KRGLEAGTPV GRQRPKLIAV 

       130        140        150        160        170        180 
TQLTSTSEEI MQNDQKIMTS LEESVINYAQ KTAQAGLDGV VCSAHEVEKI KAATSKEFIC 

       190        200        210        220        230 
LTPGIRPEGA SKGDQKRVMT PKEARTIGSD YIVVGRPITQ AKDPVASYHA IKAEWNR 

« Hide

References

« Hide 'large scale' references
[1]"A food-grade cloning system for industrial strains of Lactococcus lactis."
Soerensen K.I., Larsen R., Kibenich A., Junge M.P., Johansen E.
Appl. Environ. Microbiol. 66:1253-1258(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: CHCC377.
[2]"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IL1403.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF174425 Genomic DNA. Translation: AAF63958.1.
AE005176 Genomic DNA. Translation: AAK05443.1.
PIRA86793.
RefSeqNP_267501.1. NC_002662.1.

3D structure databases

ProteinModelPortalQ9CFW9.
SMRQ9CFW9. Positions 1-237.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272623.L181692.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK05443; AAK05443; L181692.
GeneID1114995.
KEGGlla:L181692.
PATRIC22295086. VBILacLac136773_1451.

Phylogenomic databases

eggNOGCOG0284.
HOGENOMHOG000226071.
KOK01591.
OMASAYHAIK.
OrthoDBEOG6N6815.

Enzyme and pathway databases

BioCycLLAC272623:GHSH-1434-MONOMER.
UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01200_B. OMPdecase_type1_B.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_LACLA
AccessionPrimary (citable) accession number: Q9CFW9
Secondary accession number(s): Q9L9C5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: May 14, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways