Q9CFV1 (GPO_LACLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutathione peroxidase
EC=1.11.1.9

Gene names

Name:	gpo
Ordered Locus Names:	LL1364
ORF Names:	L0198

Organism

Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)

Taxonomic identifier

272623 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus

Protein attributes

Sequence length	157 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2 glutathione + H2O2 = glutathione disulfide + 2 H2O.
Sequence similarities	Belongs to the glutathione peroxidase family.
Sequence caution	The sequence AAK05462.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Molecular function	Oxidoreductase Peroxidase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	response to oxidative stress Inferred from electronic annotation. Source: InterPro
Molecular function	glutathione peroxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 157	157	Glutathione peroxidase		PRO_0000066661
Sites
	Active site	35	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9CFV1 [UniParc]. Last modified August 30, 2002. Version 2. Checksum: 2D049998339E9CE2	FASTA	157	18,024
	10 20 30 40 50 60 MNFYDFSAFK MNGETVSMSD FKGKVVIVVN TASKCGFTPQ FEGLEKLYEN YKDQGLEILG 70 80 90 100 110 120 FPCNQFVNQD AGENSEINEF CQLNYGVTFP MFQKIKVNGK EAHPLYQFLK KEAKGALSGT 130 140 150 IKWNFTKFLI DREGNVIERF APKTEPKEME EEIQKLL

References

[1]	"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403." Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A. Genome Res. 11:731-753(2001) [PubMed: 11337471] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IL1403.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005176 Genomic DNA. Translation: AAK05462.1. Different initiation.
PIR	D86795.
RefSeq	NP_267520.2. NC_002662.1.
3D structure databases
ProteinModelPortal	Q9CFV1.
ModBase	Search...
Protein family/group databases
PeroxiBase	3753. LllGPx01_IL1403.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1115014.
GenomeReviews	Gene locus LL1364 in contig AE005176_GR.
KEGG	lla:L0198.
NMPDR	fig|272623.1.peg.1399.
PATRIC	22295124. VBILacLac136773_1470.
Phylogenomic databases
HOGENOM	HBG648990.
OMA	SFCELNF.
ProtClustDB	CLSK824609.
Enzyme and pathway databases
BioCyc	LLAC272623:L0198-MONOMER.
Family and domain databases
InterPro	IPR000889. Glutathione_peroxidase. IPR012336. Thioredoxin-like_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
KO	K00432.
PANTHER	PTHR11592. Glut_peroxidase. 1 hit.
Pfam	PF00255. GSHPx. 1 hit. [Graphical view]
PIRSF	PIRSF000303. Glutathion_perox. 1 hit.
PRINTS	PR01011. GLUTPROXDASE.
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS00460. GLUTATHIONE_PEROXID_1. 1 hit. PS00763. GLUTATHIONE_PEROXID_2. 1 hit. PS51355. GLUTATHIONE_PEROXID_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPO_LACLA

Accession

Primary (citable) accession number: Q9CFV1

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2002
Last sequence update:	August 30, 2002
Last modified:	January 25, 2012
This is version 61 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program