Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Calcium-transporting ATPase 1

Gene

yoaB

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the hydrolysis of ATP coupled with the transport of calcium.1 Publication

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).1 Publication

Enzyme regulationi

Inhibited by very high concentrations of cyclopiazonic acid (CPA).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi287Calcium; via carbonyl oxygenBy similarity1
Metal bindingi288Calcium; via carbonyl oxygenBy similarity1
Metal bindingi290Calcium; via carbonyl oxygenBy similarity1
Metal bindingi292CalciumBy similarity1
Active sitei3344-aspartylphosphate intermediateBy similarity1
Metal bindingi713CalciumBy similarity1
Metal bindingi717CalciumBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processCalcium transport, Ion transport, Transport
LigandATP-binding, Calcium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPase 1 (EC:3.6.3.8)
Alternative name(s):
LLCA1
Gene namesi
Name:yoaB
Ordered Locus Names:LL1366
ORF Names:L2866
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
Proteomesi
  • UP000002196 Componenti: Chromosome

Subcellular locationi

Q9CFU9:

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei50 – 72HelicalSequence analysisAdd BLAST23
Transmembranei76 – 95HelicalSequence analysisAdd BLAST20
Transmembranei243 – 263HelicalSequence analysisAdd BLAST21
Transmembranei281 – 301HelicalSequence analysisAdd BLAST21
Transmembranei681 – 701HelicalSequence analysisAdd BLAST21
Transmembranei704 – 724HelicalSequence analysisAdd BLAST21
Transmembranei753 – 773HelicalSequence analysisAdd BLAST21
Transmembranei779 – 799HelicalSequence analysisAdd BLAST21
Transmembranei816 – 836HelicalSequence analysisAdd BLAST21
Transmembranei845 – 865HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi54T → Q: Increases sensitivity to CPA. CPA-sensitive; when associated with L-59 and P-295. 1 Publication1
Mutagenesisi59M → L: CPA-sensitive; when associated with Q-54 and P-295. 1 Publication1
Mutagenesisi295S → P: Increases sensitivity to CPA. CPA-sensitive; when associated with Q-54 and L-59. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004245261 – 878Calcium-transporting ATPase 1Add BLAST878

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9CFU9.

Interactioni

Protein-protein interaction databases

STRINGi272623.L2866.

Structurei

3D structure databases

ProteinModelPortaliQ9CFU9.
SMRiQ9CFU9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C52. Bacteria.
COG0474. LUCA.
HOGENOMiHOG000265621.
OMAiAKIRDWG.

Family and domain databases

Gene3Di3.40.1110.10. 1 hit.
InterProiView protein in InterPro
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR036412. HAD-like_sf.
IPR001757. P_typ_ATPase.
PfamiView protein in Pfam
PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PRINTSiPR00120. HATPASE.
SMARTiView protein in SMART
SM00831. Cation_ATPase_N. 1 hit.
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81653. SSF81653. 1 hit.
SSF81660. SSF81660. 1 hit.
SSF81665. SSF81665. 3 hits.
TIGRFAMsiTIGR01494. ATPase_P-type. 3 hits.
PROSITEiView protein in PROSITE
PS00154. ATPASE_E1_E2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CFU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPYNQSVNE VLEETKSQFE GLSPKEVKNR QAKDGFNELK EKKKTSTWEL
60 70 80 90 100
FIDTLKDPMV IILLLVAFVQ LFLGEFVESL VIFIVLMINS VVAVVQTKRA
110 120 130 140 150
ESSLDALRQM SAPSAKVLRN GEKTSIPARE LVVGDIVSLE AGDFIPADGR
160 170 180 190 200
LIDVQNLRVE EGMLTGESEP VEKFSDVIEG EVALGDRKNM VFSSSLVVYG
210 220 230 240 250
RADFLVTAIA EQTEIGKIAQ MLETAEAKQT PLQQKLEKFG KQLGWVILAL
260 270 280 290 300
CALIFAVQIL RLFTTNQTAD MQKAVLDSFM FAVAVAVAAI PEALSSVVTI
310 320 330 340 350
VLSVGTNKMA KQHAIMRNLP AVETLGSTSV ICTDKTGTLT QNKMTVVDSF
360 370 380 390 400
LPTQGSKELT DLTQADQKLL LNAMVLCNDS SFSQEGQLLG DPTEVALIAY
410 420 430 440 450
SDKIGYPYQD LREKSPRLAE FPFDSERKLM STINDFEGQK TIFVKGGPDV
460 470 480 490 500
LFNRCNQVFL DGKVQEFTPE LKEKFQAQNE AFSQKALRVL AYAYKPVSDN
510 520 530 540 550
KTELTLTDEN DLILIGLSAM IDPPREAVYD SIAEAKKAGI KTIMITGDHK
560 570 580 590 600
TTAQAIAKDI GLMNEGDMAL TGQELDALTE DELRENLEKI SVYARVSPEN
610 620 630 640 650
KIRIVRAWQN EHQVTAMTGD GVNDAPALKQ ANIGIAMGSG TDVAKDASSM
660 670 680 690 700
ILTDDNFVSI VSAVSIGRVV YDNIKKSISY LFSGNLGAII AIVFALVVGW
710 720 730 740 750
VNPFTALQLL FINLVNDSVP AIALGMEKAE PDVMEKAPRQ LNEGIFANGL
760 770 780 790 800
MRVILIRGSL IGIAAIISQY VGQKTSPEMG VAMAFTTLIL ARTLQTFAAR
810 820 830 840 850
SNSQNILKLG FTTNKYVLMA VTFCLALYSL TTLPFLREIF SIPAAFGWSQ
860 870
WIVAAGLAVI AVICMEILKS IKGVFEKH
Length:878
Mass (Da):96,033
Last modified:June 1, 2001 - v1
Checksum:i0D322BB263E3DF36
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005176 Genomic DNA. Translation: AAK05464.1.
PIRiF86795.
RefSeqiNP_267522.1. NC_002662.1.
WP_010905909.1. NC_002662.1.

Genome annotation databases

EnsemblBacteriaiAAK05464; AAK05464; L2866.
GeneIDi1115016.
KEGGilla:L2866.
PATRICifig|272623.7.peg.1472.

Similar proteinsi

Entry informationi

Entry nameiLLCA1_LACLA
AccessioniPrimary (citable) accession number: Q9CFU9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2013
Last sequence update: June 1, 2001
Last modified: October 25, 2017
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families