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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Bifunctional purine biosynthesis protein PurH (purH)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route), the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Bifunctional purine biosynthesis protein PurH (purH)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Multifunctional enzyme, Transferase
Biological processPurine biosynthesis

Enzyme and pathway databases

BioCyciLLAC272623:G1FZA-1600-MONOMER
UniPathwayiUPA00074; UER00133
UPA00074; UER00135

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:LL1518
ORF Names:L158710
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
Proteomesi
  • UP000002196 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001920961 – 518Bifunctional purine biosynthesis protein PurHAdd BLAST518

Proteomic databases

PaxDbiQ9CFG0
PRIDEiQ9CFG0

Interactioni

Protein-protein interaction databases

STRINGi272623.L158710

Structurei

3D structure databases

ProteinModelPortaliQ9CFG0
SMRiQ9CFG0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 144MGS-likePROSITE-ProRule annotationAdd BLAST144

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotationCurated

Phylogenomic databases

eggNOGiENOG4105DC1 Bacteria
COG0138 LUCA
HOGENOMiHOG000230373
KOiK00602
OMAiNISFEDG

Family and domain databases

Gene3Di3.40.140.20, 2 hits
3.40.50.1380, 1 hit
HAMAPiMF_00139 PurH, 1 hit
InterProiView protein in InterPro
IPR024051 AICAR_Tfase_dup_dom_sf
IPR016193 Cytidine_deaminase-like
IPR011607 MGS-like_dom
IPR036914 MGS-like_dom_sf
IPR002695 PurH-like
PANTHERiPTHR11692 PTHR11692, 1 hit
PfamiView protein in Pfam
PF01808 AICARFT_IMPCHas, 1 hit
PF02142 MGS, 1 hit
PIRSFiPIRSF000414 AICARFT_IMPCHas, 1 hit
SMARTiView protein in SMART
SM00798 AICARFT_IMPCHas, 1 hit
SM00851 MGS, 1 hit
SUPFAMiSSF52335 SSF52335, 1 hit
SSF53927 SSF53927, 1 hit
TIGRFAMsiTIGR00355 purH, 1 hit
PROSITEiView protein in PROSITE
PS51855 MGS, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CFG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKRALISVS DKEGIVEFAK EIRELGWEII STGGTKAVLD QEEIPNIAID
60 70 80 90 100
EVTGFPEMMD GRLKTLHPLI HGALLGRRDL ESHMKSMTEH HISPIDLVVV
110 120 130 140 150
NLYPFKETLL AGGSQAEMIE KIDIGGPSML RSAAKNHASV TVVCDPNDYE
160 170 180 190 200
KVLTELSVKG ETSLSFRQQL AAKVFRHTAS YDALIAQYLT EEFPVENVKP
210 220 230 240 250
EKLTLTYDLK QGMRYGENPQ QNADFYESGI PTTYSIAQSK QIHGKELSYN
260 270 280 290 300
NVRDADAALQ IARDFEEPTV VALKHMNPCG IGTATDIEKA WDYAYEADPV
310 320 330 340 350
SIFGGIIVLN REVTLATAQK MSKIFLEIII APSYSKEALE VLSKKKNIRL
360 370 380 390 400
LTVDFSKKEA SEKEALVTGV LGGLLVQNQD VIVENPKEWT VATKVQPTDR
410 420 430 440 450
QMEAMKFAWK AVKFVKSNGI IVTNDHQTLG VGPGQTNRVG SVKIALEATA
460 470 480 490 500
DKSVELQENA VLGSDAFFPF ADNIDEIAKA GIKAIVQPGG SVRDQEVIDA
510
CDKYGIAMVF TGLRHFRH
Length:518
Mass (Da):57,094
Last modified:April 27, 2001 - v1
Checksum:i0DCF725A77AC234B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005176 Genomic DNA Translation: AAK05616.1
PIRiF86814
RefSeqiNP_267674.1, NC_002662.1
WP_003130058.1, NC_002662.1

Genome annotation databases

EnsemblBacteriaiAAK05616; AAK05616; L158710
GeneIDi1115175
KEGGilla:L158710
PATRICifig|272623.7.peg.1628

Similar proteinsi

Entry informationi

Entry nameiPUR9_LACLA
AccessioniPrimary (citable) accession number: Q9CFG0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: May 23, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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