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Q9CFF4

- PUR5_LACLA

UniProt

Q9CFF4 - PUR5_LACLA

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene
purM, LL1524, L165202
Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLLAC272623:GHSH-1621-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:LL1524
ORF Names:L165202
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
ProteomesiUP000002196: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotationPRO_0000148216Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272623.L165202.

Structurei

3D structure databases

ProteinModelPortaliQ9CFF4.
SMRiQ9CFF4. Positions 14-318.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229091.
KOiK01933.
OMAiTKVMLAQ.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CFF4-1 [UniParc]FASTAAdd to Basket

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MSENAYAKSG VDVEAGYEVV SRIKKHVAKT ERLGVLGALG GFGGSFDLSV    50
LDVKEPVLIS GTDGVGTKLM LAIQADKHDT IGIDCVAMCV NDIIAAGAEP 100
LYFLDYIATG KNIPEKLEQV VAGVAEGCLQ AGAALIGGET AEMPGMYDED 150
DYDLAGFAVG VAEKSQLIDG EKDVEAGDVL LGLASSGIHS NGYSLVRKVF 200
SDFDLNESLP ELDQSLIDTL LTPTKIYVKE LLPLIKQNKI KGIAHITGGG 250
FHENLPRMFG NSLSAEIVEG SWNILPIFKA LEKYGDIKHE EMYEIFNMGI 300
GMVIAVAPEN AEALKKVLNA FEIGKMVKRQ DSAVVIKK 338
Length:338
Mass (Da):36,139
Last modified:June 1, 2001 - v1
Checksum:iA84E9B89117C0F20
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005176 Genomic DNA. Translation: AAK05622.1.
PIRiD86815.
RefSeqiNP_267680.1. NC_002662.1.

Genome annotation databases

EnsemblBacteriaiAAK05622; AAK05622; L165202.
GeneIDi1115181.
KEGGilla:L165202.
PATRICi22295456. VBILacLac136773_1635.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005176 Genomic DNA. Translation: AAK05622.1 .
PIRi D86815.
RefSeqi NP_267680.1. NC_002662.1.

3D structure databases

ProteinModelPortali Q9CFF4.
SMRi Q9CFF4. Positions 14-318.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272623.L165202.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK05622 ; AAK05622 ; L165202 .
GeneIDi 1115181.
KEGGi lla:L165202.
PATRICi 22295456. VBILacLac136773_1635.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229091.
KOi K01933.
OMAi TKVMLAQ.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci LLAC272623:GHSH-1621-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
    Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
    Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IL1403.

Entry informationi

Entry nameiPUR5_LACLA
AccessioniPrimary (citable) accession number: Q9CFF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: June 1, 2001
Last modified: May 14, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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