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Protein

Dihydroorotate dehydrogenase A (fumarate)

Gene

pyrDA

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor.By similarity

Catalytic activityi

(S)-dihydroorotate + fumarate = orotate + succinate.

Cofactori

FMNBy similarityNote: Binds 1 FMN per subunit.By similarity

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in the pathway UMP biosynthesis via de novo pathway, which is part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei19FMNBy similarity1
Binding sitei43SubstrateBy similarity1
Binding sitei127FMNBy similarity1
Binding sitei127SubstrateBy similarity1
Active sitei130Nucleophile1
Binding sitei164FMNBy similarity1
Binding sitei192FMN; via carbonyl oxygenBy similarity1
Binding sitei221FMN; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi43 – 44FMNBy similarity2
Nucleotide bindingi249 – 250FMNBy similarity2
Nucleotide bindingi271 – 272FMNBy similarity2

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyrimidine biosynthesis

Keywords - Ligandi

Flavoprotein, FMN

Enzyme and pathway databases

SABIO-RKQ9CFC9.
UniPathwayiUPA00070.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydroorotate dehydrogenase A (fumarate) (EC:1.3.98.1)
Short name:
DHOD A
Short name:
DHODase A
Short name:
DHOdehase A
Gene namesi
Name:pyrDA
Synonyms:pydA
Ordered Locus Names:LL1552
ORF Names:L192589
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
Proteomesi
  • UP000002196 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001483931 – 311Dihydroorotate dehydrogenase A (fumarate)Add BLAST311

Proteomic databases

PaxDbiQ9CFC9.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi272623.L192589.

Structurei

3D structure databases

ProteinModelPortaliQ9CFC9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni67 – 71Substrate bindingBy similarity5
Regioni193 – 194Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107RY0. Bacteria.
COG0167. LUCA.
HOGENOMiHOG000225104.
KOiK00226.
OMAiNTIENAC.

Family and domain databases

CDDicd04741. DHOD_1A_like. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00224. DHO_dh_type1. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR033886. DHOD_1A.
IPR005720. Dihydroorotate_DH.
IPR024920. Dihydroorotate_DH_1.
IPR012135. Dihydroorotate_DH_1_2.
IPR001295. Dihydroorotate_DH_CS.
[Graphical view]
PfamiPF01180. DHO_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000164. DHO_oxidase. 1 hit.
TIGRFAMsiTIGR01037. pyrD_sub1_fam. 1 hit.
PROSITEiPS00911. DHODEHASE_1. 1 hit.
PS00912. DHODEHASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CFC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKTTFANAE FANPFMNASG VHCMTTEDLE ELKASQAGAY ITKSSTLEKR
60 70 80 90 100
EGNPLPRYVD LELGSINSMG LPNLGFDYYL DYVLKNQKEK AQEAPIFFSI
110 120 130 140 150
AGMSAAENIA MLKKIQESNF SGITELNLSC PNVPGKPQLA YDFEATEKLL
160 170 180 190 200
KEVFTFFTKP LGVKLPPYFD LVHFDIMAEI LNQFPLTYVN SVNSIGNGLF
210 220 230 240 250
IDSEAESVVI KPKDGFGGIG GAYIKPTALA NVRAFYTRLK PEIKIIGTGG
260 270 280 290 300
IETGQDAFEH LLCGATMLQI GTALHKEGPA IFDRIIKELE EIMDKKGYQS
310
IADFHGKLKS L
Length:311
Mass (Da):34,231
Last modified:June 1, 2001 - v1
Checksum:i80B3619EC408BBA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005176 Genomic DNA. Translation: AAK05650.1.
PIRiH86818.
RefSeqiNP_267708.1. NC_002662.1.
WP_003130679.1. NC_002662.1.

Genome annotation databases

EnsemblBacteriaiAAK05650; AAK05650; L192589.
GeneIDi1115211.
KEGGilla:L192589.
PATRICi22295518. VBILacLac136773_1666.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005176 Genomic DNA. Translation: AAK05650.1.
PIRiH86818.
RefSeqiNP_267708.1. NC_002662.1.
WP_003130679.1. NC_002662.1.

3D structure databases

ProteinModelPortaliQ9CFC9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272623.L192589.

Proteomic databases

PaxDbiQ9CFC9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK05650; AAK05650; L192589.
GeneIDi1115211.
KEGGilla:L192589.
PATRICi22295518. VBILacLac136773_1666.

Phylogenomic databases

eggNOGiENOG4107RY0. Bacteria.
COG0167. LUCA.
HOGENOMiHOG000225104.
KOiK00226.
OMAiNTIENAC.

Enzyme and pathway databases

UniPathwayiUPA00070.
SABIO-RKQ9CFC9.

Family and domain databases

CDDicd04741. DHOD_1A_like. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00224. DHO_dh_type1. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR033886. DHOD_1A.
IPR005720. Dihydroorotate_DH.
IPR024920. Dihydroorotate_DH_1.
IPR012135. Dihydroorotate_DH_1_2.
IPR001295. Dihydroorotate_DH_CS.
[Graphical view]
PfamiPF01180. DHO_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000164. DHO_oxidase. 1 hit.
TIGRFAMsiTIGR01037. pyrD_sub1_fam. 1 hit.
PROSITEiPS00911. DHODEHASE_1. 1 hit.
PS00912. DHODEHASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPYRDA_LACLA
AccessioniPrimary (citable) accession number: Q9CFC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.