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Q9CFC9

- PYRDA_LACLA

UniProt

Q9CFC9 - PYRDA_LACLA

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Protein

Dihydroorotate dehydrogenase A (fumarate)

Gene
pyrDA, pydA, LL1552, L192589
Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor By similarity.UniRule annotation

Catalytic activityi

(S)-dihydroorotate + fumarate = orotate + succinate.UniRule annotation

Cofactori

Binds 1 FMN per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei19 – 191FMN By similarity
Binding sitei43 – 431Substrate By similarity
Binding sitei127 – 1271FMN By similarity
Binding sitei127 – 1271Substrate By similarity
Active sitei130 – 1301Nucleophile
Binding sitei164 – 1641FMN By similarity
Binding sitei192 – 1921FMN; via carbonyl oxygen By similarity
Binding sitei221 – 2211FMN; via amide nitrogen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi43 – 442FMN By similarity
Nucleotide bindingi249 – 2502FMN By similarity
Nucleotide bindingi271 – 2722FMN By similarity

GO - Molecular functioni

  1. dihydroorotate oxidase activity Source: InterPro

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyrimidine biosynthesis

Keywords - Ligandi

Flavoprotein, FMN

Enzyme and pathway databases

BioCyciLLAC272623:GHSH-1651-MONOMER.
SABIO-RKQ9CFC9.
UniPathwayiUPA00070.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydroorotate dehydrogenase A (fumarate) (EC:1.3.98.1)
Short name:
DHOD A
Short name:
DHODase A
Short name:
DHOdehase A
Gene namesi
Name:pyrDA
Synonyms:pydA
Ordered Locus Names:LL1552
ORF Names:L192589
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
ProteomesiUP000002196: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Dihydroorotate dehydrogenase A (fumarate)UniRule annotationPRO_0000148393Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi272623.L192589.

Structurei

3D structure databases

ProteinModelPortaliQ9CFC9.
SMRiQ9CFC9. Positions 1-311.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni67 – 715Substrate binding By similarity
Regioni193 – 1942Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0167.
HOGENOMiHOG000225104.
KOiK00226.
OMAiDFDNCLM.
OrthoDBiEOG6NPM9S.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00224. DHO_dh_type1.
InterProiIPR013785. Aldolase_TIM.
IPR005720. Dihydroorotate_DH.
IPR024920. Dihydroorotate_DH_1.
IPR012135. Dihydroorotate_DH_1_2.
IPR001295. Dihydroorotate_DH_CS.
[Graphical view]
PfamiPF01180. DHO_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000164. DHO_oxidase. 1 hit.
TIGRFAMsiTIGR01037. pyrD_sub1_fam. 1 hit.
PROSITEiPS00911. DHODEHASE_1. 1 hit.
PS00912. DHODEHASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CFC9-1 [UniParc]FASTAAdd to Basket

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MLKTTFANAE FANPFMNASG VHCMTTEDLE ELKASQAGAY ITKSSTLEKR    50
EGNPLPRYVD LELGSINSMG LPNLGFDYYL DYVLKNQKEK AQEAPIFFSI 100
AGMSAAENIA MLKKIQESNF SGITELNLSC PNVPGKPQLA YDFEATEKLL 150
KEVFTFFTKP LGVKLPPYFD LVHFDIMAEI LNQFPLTYVN SVNSIGNGLF 200
IDSEAESVVI KPKDGFGGIG GAYIKPTALA NVRAFYTRLK PEIKIIGTGG 250
IETGQDAFEH LLCGATMLQI GTALHKEGPA IFDRIIKELE EIMDKKGYQS 300
IADFHGKLKS L 311
Length:311
Mass (Da):34,231
Last modified:June 1, 2001 - v1
Checksum:i80B3619EC408BBA8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005176 Genomic DNA. Translation: AAK05650.1.
PIRiH86818.
RefSeqiNP_267708.1. NC_002662.1.

Genome annotation databases

EnsemblBacteriaiAAK05650; AAK05650; L192589.
GeneIDi1115211.
KEGGilla:L192589.
PATRICi22295518. VBILacLac136773_1666.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005176 Genomic DNA. Translation: AAK05650.1 .
PIRi H86818.
RefSeqi NP_267708.1. NC_002662.1.

3D structure databases

ProteinModelPortali Q9CFC9.
SMRi Q9CFC9. Positions 1-311.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272623.L192589.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK05650 ; AAK05650 ; L192589 .
GeneIDi 1115211.
KEGGi lla:L192589.
PATRICi 22295518. VBILacLac136773_1666.

Phylogenomic databases

eggNOGi COG0167.
HOGENOMi HOG000225104.
KOi K00226.
OMAi DFDNCLM.
OrthoDBi EOG6NPM9S.

Enzyme and pathway databases

UniPathwayi UPA00070 .
BioCyci LLAC272623:GHSH-1651-MONOMER.
SABIO-RK Q9CFC9.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00224. DHO_dh_type1.
InterProi IPR013785. Aldolase_TIM.
IPR005720. Dihydroorotate_DH.
IPR024920. Dihydroorotate_DH_1.
IPR012135. Dihydroorotate_DH_1_2.
IPR001295. Dihydroorotate_DH_CS.
[Graphical view ]
Pfami PF01180. DHO_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000164. DHO_oxidase. 1 hit.
TIGRFAMsi TIGR01037. pyrD_sub1_fam. 1 hit.
PROSITEi PS00911. DHODEHASE_1. 1 hit.
PS00912. DHODEHASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
    Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
    Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IL1403.

Entry informationi

Entry nameiPYRDA_LACLA
AccessioniPrimary (citable) accession number: Q9CFC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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