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Q9CFC9

- PYRDA_LACLA

UniProt

Q9CFC9 - PYRDA_LACLA

Protein

Dihydroorotate dehydrogenase A (fumarate)

Gene

pyrDA

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor.By similarity

    Catalytic activityi

    (S)-dihydroorotate + fumarate = orotate + succinate.

    Cofactori

    Binds 1 FMN per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei19 – 191FMNBy similarity
    Binding sitei43 – 431SubstrateBy similarity
    Binding sitei127 – 1271FMNBy similarity
    Binding sitei127 – 1271SubstrateBy similarity
    Active sitei130 – 1301Nucleophile
    Binding sitei164 – 1641FMNBy similarity
    Binding sitei192 – 1921FMN; via carbonyl oxygenBy similarity
    Binding sitei221 – 2211FMN; via amide nitrogenBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi43 – 442FMNBy similarity
    Nucleotide bindingi249 – 2502FMNBy similarity
    Nucleotide bindingi271 – 2722FMNBy similarity

    GO - Molecular functioni

    1. dihydroorotate oxidase activity Source: InterPro

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Keywords - Ligandi

    Flavoprotein, FMN

    Enzyme and pathway databases

    BioCyciLLAC272623:GHSH-1651-MONOMER.
    SABIO-RKQ9CFC9.
    UniPathwayiUPA00070.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dihydroorotate dehydrogenase A (fumarate) (EC:1.3.98.1)
    Short name:
    DHOD A
    Short name:
    DHODase A
    Short name:
    DHOdehase A
    Gene namesi
    Name:pyrDA
    Synonyms:pydA
    Ordered Locus Names:LL1552
    ORF Names:L192589
    OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
    Taxonomic identifieri272623 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
    ProteomesiUP000002196: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 311311Dihydroorotate dehydrogenase A (fumarate)PRO_0000148393Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi272623.L192589.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CFC9.
    SMRiQ9CFC9. Positions 1-311.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni67 – 715Substrate bindingBy similarity
    Regioni193 – 1942Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0167.
    HOGENOMiHOG000225104.
    KOiK00226.
    OMAiDFDNCLM.
    OrthoDBiEOG6NPM9S.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00224. DHO_dh_type1.
    InterProiIPR013785. Aldolase_TIM.
    IPR005720. Dihydroorotate_DH.
    IPR024920. Dihydroorotate_DH_1.
    IPR012135. Dihydroorotate_DH_1_2.
    IPR001295. Dihydroorotate_DH_CS.
    [Graphical view]
    PfamiPF01180. DHO_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000164. DHO_oxidase. 1 hit.
    TIGRFAMsiTIGR01037. pyrD_sub1_fam. 1 hit.
    PROSITEiPS00911. DHODEHASE_1. 1 hit.
    PS00912. DHODEHASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9CFC9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKTTFANAE FANPFMNASG VHCMTTEDLE ELKASQAGAY ITKSSTLEKR    50
    EGNPLPRYVD LELGSINSMG LPNLGFDYYL DYVLKNQKEK AQEAPIFFSI 100
    AGMSAAENIA MLKKIQESNF SGITELNLSC PNVPGKPQLA YDFEATEKLL 150
    KEVFTFFTKP LGVKLPPYFD LVHFDIMAEI LNQFPLTYVN SVNSIGNGLF 200
    IDSEAESVVI KPKDGFGGIG GAYIKPTALA NVRAFYTRLK PEIKIIGTGG 250
    IETGQDAFEH LLCGATMLQI GTALHKEGPA IFDRIIKELE EIMDKKGYQS 300
    IADFHGKLKS L 311
    Length:311
    Mass (Da):34,231
    Last modified:June 1, 2001 - v1
    Checksum:i80B3619EC408BBA8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005176 Genomic DNA. Translation: AAK05650.1.
    PIRiH86818.
    RefSeqiNP_267708.1. NC_002662.1.

    Genome annotation databases

    EnsemblBacteriaiAAK05650; AAK05650; L192589.
    GeneIDi1115211.
    KEGGilla:L192589.
    PATRICi22295518. VBILacLac136773_1666.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005176 Genomic DNA. Translation: AAK05650.1 .
    PIRi H86818.
    RefSeqi NP_267708.1. NC_002662.1.

    3D structure databases

    ProteinModelPortali Q9CFC9.
    SMRi Q9CFC9. Positions 1-311.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272623.L192589.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK05650 ; AAK05650 ; L192589 .
    GeneIDi 1115211.
    KEGGi lla:L192589.
    PATRICi 22295518. VBILacLac136773_1666.

    Phylogenomic databases

    eggNOGi COG0167.
    HOGENOMi HOG000225104.
    KOi K00226.
    OMAi DFDNCLM.
    OrthoDBi EOG6NPM9S.

    Enzyme and pathway databases

    UniPathwayi UPA00070 .
    BioCyci LLAC272623:GHSH-1651-MONOMER.
    SABIO-RK Q9CFC9.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00224. DHO_dh_type1.
    InterProi IPR013785. Aldolase_TIM.
    IPR005720. Dihydroorotate_DH.
    IPR024920. Dihydroorotate_DH_1.
    IPR012135. Dihydroorotate_DH_1_2.
    IPR001295. Dihydroorotate_DH_CS.
    [Graphical view ]
    Pfami PF01180. DHO_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000164. DHO_oxidase. 1 hit.
    TIGRFAMsi TIGR01037. pyrD_sub1_fam. 1 hit.
    PROSITEi PS00911. DHODEHASE_1. 1 hit.
    PS00912. DHODEHASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
      Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
      Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: IL1403.

    Entry informationi

    Entry nameiPYRDA_LACLA
    AccessioniPrimary (citable) accession number: Q9CFC9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3