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Q9CFB4 (HEMH_LACLA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:LL1567
ORF Names:L0194
OrganismLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifier272623 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 314314Ferrochelatase HAMAP MF_00323
PRO_0000175152

Sites

Metal binding1861Iron By similarity
Metal binding2681Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9CFB4 [UniParc].

Last modified April 27, 2001. Version 1.
Checksum: 00B03F49869B5E1F

FASTA31436,436
        10         20         30         40         50         60 
MDKKKGILLV ALGTPRSCEA DDVRDYLKEF LGDPLVIQKP RWLWLPILNG IILKVRPQKS 

        70         80         90        100        110        120 
AEMYKKIWTD EGSPLMIYTV AQAKQLQDMR EDFDVRFAMT YGEPRIDKVI AEMKESGVEE 

       130        140        150        160        170        180 
ITVLPLYPQY SLTTVEPVIQ QVKKIDDKIK VIRDFHKVES YSDLLAESIR EKWQANDYDK 

       190        200        210        220        230        240 
LVLSYHGIPL SYVTKKKDAY EEQCKETTRL VVSKLGLREE EYEHTYQSKF GPEKWLEPAT 

       250        260        270        280        290        300 
IDRVAELPKE NAKKVLICSP AFVADCLETL FELEIENKEV FVENGGETFD FVHPFNDSLD 

       310 
FTRVLSEVVD QNRL

« Hide

References

[1]"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
Genome Res. 11:731-753(2001) [PubMed: 11337471] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IL1403.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE005176 Genomic DNA. Translation: AAK05665.1.
PIRG86820.
RefSeqNP_267723.1. NC_002662.1.

3D structure databases

ProteinModelPortalQ9CFB4.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1115227.
GenomeReviewsGene locus LL1567 in contig AE005176_GR.
KEGGlla:L0194.
NMPDRfig|272623.1.peg.1609.
PATRIC22295556. VBILacLac136773_1685.

Phylogenomic databases

HOGENOMHBG697135.
OMATIEEIGM.
ProtClustDBCLSK697807.

Enzyme and pathway databases

BioCycLLAC272623:L0194-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_LACLA
AccessionPrimary (citable) accession number: Q9CFB4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: January 25, 2012
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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