ID UXUA_LACLA Reviewed; 358 AA. AC Q9CF50; DT 06-JUN-2002, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2001, sequence version 1. DT 27-MAR-2024, entry version 113. DE RecName: Full=Mannonate dehydratase {ECO:0000255|HAMAP-Rule:MF_00106}; DE EC=4.2.1.8 {ECO:0000255|HAMAP-Rule:MF_00106}; DE AltName: Full=D-mannonate hydro-lyase {ECO:0000255|HAMAP-Rule:MF_00106}; GN Name=uxuA {ECO:0000255|HAMAP-Rule:MF_00106}; OrderedLocusNames=LL1631; GN ORFNames=L0020; OS Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis). OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae; OC Lactococcus. OX NCBI_TaxID=272623; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=IL1403; RX PubMed=11337471; DOI=10.1101/gr.gr-1697r; RA Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., RA Ehrlich S.D., Sorokin A.; RT "The complete genome sequence of the lactic acid bacterium Lactococcus RT lactis ssp. lactis IL1403."; RL Genome Res. 11:731-753(2001). CC -!- FUNCTION: Catalyzes the dehydration of D-mannonate. {ECO:0000255|HAMAP- CC Rule:MF_00106}. CC -!- CATALYTIC ACTIVITY: CC Reaction=D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O; CC Xref=Rhea:RHEA:20097, ChEBI:CHEBI:15377, ChEBI:CHEBI:17767, CC ChEBI:CHEBI:57990; EC=4.2.1.8; Evidence={ECO:0000255|HAMAP- CC Rule:MF_00106}; CC -!- COFACTOR: CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence={ECO:0000255|HAMAP- CC Rule:MF_00106}; CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000255|HAMAP- CC Rule:MF_00106}; CC -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate CC interconversion. {ECO:0000255|HAMAP-Rule:MF_00106}. CC -!- SIMILARITY: Belongs to the mannonate dehydratase family. CC {ECO:0000255|HAMAP-Rule:MF_00106}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE005176; AAK05729.1; -; Genomic_DNA. DR PIR; G86828; G86828. DR RefSeq; NP_267787.1; NC_002662.1. DR RefSeq; WP_010906067.1; NC_002662.1. DR AlphaFoldDB; Q9CF50; -. DR SMR; Q9CF50; -. DR PaxDb; 272623-L0020; -. DR EnsemblBacteria; AAK05729; AAK05729; L0020. DR KEGG; lla:L0020; -. DR PATRIC; fig|272623.7.peg.1752; -. DR eggNOG; COG1312; Bacteria. DR HOGENOM; CLU_058621_1_0_9; -. DR OrthoDB; 9780250at2; -. DR UniPathway; UPA00246; -. DR Proteomes; UP000002196; Chromosome. DR GO; GO:0008927; F:mannonate dehydratase activity; IEA:UniProtKB-UniRule. DR GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro. DR Gene3D; 3.20.20.150; Divalent-metal-dependent TIM barrel enzymes; 1. DR HAMAP; MF_00106; UxuA; 1. DR InterPro; IPR004628; Man_deHydtase. DR InterPro; IPR036237; Xyl_isomerase-like_sf. DR NCBIfam; TIGR00695; uxuA; 1. DR PANTHER; PTHR30387; MANNONATE DEHYDRATASE; 1. DR PANTHER; PTHR30387:SF2; MANNONATE DEHYDRATASE; 1. DR Pfam; PF03786; UxuA; 1. DR PIRSF; PIRSF016049; Man_dehyd; 1. DR SUPFAM; SSF51658; Xylose isomerase-like; 1. PE 3: Inferred from homology; KW Iron; Lyase; Manganese; Reference proteome. FT CHAIN 1..358 FT /note="Mannonate dehydratase" FT /id="PRO_0000170676" SQ SEQUENCE 358 AA; 40826 MW; FD30ABEDEC5C5CE4 CRC64; MEMTMRWFGS NADKIKLSEI AQVPGVKGVV GMIMDIPAGE IWPKERIKAL KEEIEAAGLT LKVIESVNIH DDIKIGLPTR DKYIENYKET IRNLAEFGIE VICYNFMPVF DWLKSDLDYR LADNSQTMAF VARDIPANPQ EIIDRVQAAD GCFSLPGWEP ERLSEVRGLF EAYKNVDEHK LRENFAYFLK AIIPTCEEVG IKMAVHPDDP PYPMFGLPRV VKNREDLDWI CNVVDSPSNA ITLCTGSIAE DPANNVYEIM AEFVKRDRIP FAHVRNIKFL PSGKKDFYEA PHMSKYGSLD MYKIMKAMYD NGFDGYIRPD HGRMIWGETG RPGYGLYDRA LGASYLNGLW EALEKTNQ //