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Protein

Mannonate dehydratase

Gene

uxuA

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dehydration of D-mannonate.UniRule annotation

Catalytic activityi

D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O.UniRule annotation

Cofactori

Fe2+UniRule annotation, Mn2+UniRule annotation

Pathwayi: pentose and glucuronate interconversion

This protein is involved in the pathway pentose and glucuronate interconversion, which is part of Carbohydrate metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway pentose and glucuronate interconversion and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
LigandIron, Manganese

Enzyme and pathway databases

UniPathwayiUPA00246.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannonate dehydrataseUniRule annotation (EC:4.2.1.8UniRule annotation)
Alternative name(s):
D-mannonate hydro-lyaseUniRule annotation
Gene namesi
Name:uxuAUniRule annotation
Ordered Locus Names:LL1631
ORF Names:L0020
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
Proteomesi
  • UP000002196 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001706761 – 358Mannonate dehydrataseAdd BLAST358

Proteomic databases

PaxDbiQ9CF50.

Interactioni

Protein-protein interaction databases

STRINGi272623.L0020.

Structurei

3D structure databases

ProteinModelPortaliQ9CF50.
SMRiQ9CF50.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mannonate dehydratase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CHZ. Bacteria.
COG1312. LUCA.
KOiK01686.
OMAiIPNGQVW.

Family and domain databases

HAMAPiMF_00106. UxuA. 1 hit.
InterProiView protein in InterPro
IPR004628. Man_deHydtase.
IPR013022. Xyl_isomerase-like_TIM-brl.
PANTHERiPTHR30387:SF3. PTHR30387:SF3. 1 hit.
PfamiView protein in Pfam
PF03786. UxuA. 1 hit.
PIRSFiPIRSF016049. Man_dehyd. 2 hits.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR00695. uxuA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CF50-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMTMRWFGS NADKIKLSEI AQVPGVKGVV GMIMDIPAGE IWPKERIKAL
60 70 80 90 100
KEEIEAAGLT LKVIESVNIH DDIKIGLPTR DKYIENYKET IRNLAEFGIE
110 120 130 140 150
VICYNFMPVF DWLKSDLDYR LADNSQTMAF VARDIPANPQ EIIDRVQAAD
160 170 180 190 200
GCFSLPGWEP ERLSEVRGLF EAYKNVDEHK LRENFAYFLK AIIPTCEEVG
210 220 230 240 250
IKMAVHPDDP PYPMFGLPRV VKNREDLDWI CNVVDSPSNA ITLCTGSIAE
260 270 280 290 300
DPANNVYEIM AEFVKRDRIP FAHVRNIKFL PSGKKDFYEA PHMSKYGSLD
310 320 330 340 350
MYKIMKAMYD NGFDGYIRPD HGRMIWGETG RPGYGLYDRA LGASYLNGLW

EALEKTNQ
Length:358
Mass (Da):40,826
Last modified:June 1, 2001 - v1
Checksum:iFD30ABEDEC5C5CE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005176 Genomic DNA. Translation: AAK05729.1.
PIRiG86828.
RefSeqiNP_267787.1. NC_002662.1.
WP_010906067.1. NC_002662.1.

Genome annotation databases

EnsemblBacteriaiAAK05729; AAK05729; L0020.
GeneIDi1115291.
KEGGilla:L0020.
PATRICifig|272623.7.peg.1752.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiUXUA_LACLA
AccessioniPrimary (citable) accession number: Q9CF50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: June 1, 2001
Last modified: July 5, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families