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Q9CF50

- UXUA_LACLA

UniProt

Q9CF50 - UXUA_LACLA

Protein

Mannonate dehydratase

Gene

uxuA

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the dehydration of D-mannonate.UniRule annotation

    Catalytic activityi

    D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O.UniRule annotation

    Cofactori

    Fe2+ or Mn2+ ion.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. mannonate dehydratase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glucuronate catabolic process Source: InterPro

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    Iron, Manganese

    Enzyme and pathway databases

    BioCyciLLAC272623:GHSH-1731-MONOMER.
    UniPathwayiUPA00246.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mannonate dehydrataseUniRule annotation (EC:4.2.1.8UniRule annotation)
    Alternative name(s):
    D-mannonate hydro-lyaseUniRule annotation
    Gene namesi
    Name:uxuAUniRule annotation
    Ordered Locus Names:LL1631
    ORF Names:L0020
    OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
    Taxonomic identifieri272623 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
    ProteomesiUP000002196: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 358358Mannonate dehydratasePRO_0000170676Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272623.L0020.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CF50.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the mannonate dehydratase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1312.
    KOiK01686.
    OMAiRQIPGIY.
    OrthoDBiEOG6ZSP6Z.

    Family and domain databases

    Gene3Di3.20.20.150. 1 hit.
    HAMAPiMF_00106. UxuA.
    InterProiIPR004628. Man_deHydtase.
    IPR013022. Xyl_isomerase-like_TIM-brl.
    [Graphical view]
    PfamiPF03786. UxuA. 1 hit.
    [Graphical view]
    PIRSFiPIRSF016049. Man_dehyd. 1 hit.
    SUPFAMiSSF51658. SSF51658. 1 hit.
    TIGRFAMsiTIGR00695. uxuA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9CF50-1 [UniParc]FASTAAdd to Basket

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    MEMTMRWFGS NADKIKLSEI AQVPGVKGVV GMIMDIPAGE IWPKERIKAL    50
    KEEIEAAGLT LKVIESVNIH DDIKIGLPTR DKYIENYKET IRNLAEFGIE 100
    VICYNFMPVF DWLKSDLDYR LADNSQTMAF VARDIPANPQ EIIDRVQAAD 150
    GCFSLPGWEP ERLSEVRGLF EAYKNVDEHK LRENFAYFLK AIIPTCEEVG 200
    IKMAVHPDDP PYPMFGLPRV VKNREDLDWI CNVVDSPSNA ITLCTGSIAE 250
    DPANNVYEIM AEFVKRDRIP FAHVRNIKFL PSGKKDFYEA PHMSKYGSLD 300
    MYKIMKAMYD NGFDGYIRPD HGRMIWGETG RPGYGLYDRA LGASYLNGLW 350
    EALEKTNQ 358
    Length:358
    Mass (Da):40,826
    Last modified:June 1, 2001 - v1
    Checksum:iFD30ABEDEC5C5CE4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005176 Genomic DNA. Translation: AAK05729.1.
    PIRiG86828.
    RefSeqiNP_267787.1. NC_002662.1.
    WP_010906067.1. NC_002662.1.

    Genome annotation databases

    EnsemblBacteriaiAAK05729; AAK05729; L0020.
    GeneIDi1115291.
    KEGGilla:L0020.
    PATRICi22295690. VBILacLac136773_1752.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005176 Genomic DNA. Translation: AAK05729.1 .
    PIRi G86828.
    RefSeqi NP_267787.1. NC_002662.1.
    WP_010906067.1. NC_002662.1.

    3D structure databases

    ProteinModelPortali Q9CF50.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272623.L0020.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK05729 ; AAK05729 ; L0020 .
    GeneIDi 1115291.
    KEGGi lla:L0020.
    PATRICi 22295690. VBILacLac136773_1752.

    Phylogenomic databases

    eggNOGi COG1312.
    KOi K01686.
    OMAi RQIPGIY.
    OrthoDBi EOG6ZSP6Z.

    Enzyme and pathway databases

    UniPathwayi UPA00246 .
    BioCyci LLAC272623:GHSH-1731-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.150. 1 hit.
    HAMAPi MF_00106. UxuA.
    InterProi IPR004628. Man_deHydtase.
    IPR013022. Xyl_isomerase-like_TIM-brl.
    [Graphical view ]
    Pfami PF03786. UxuA. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF016049. Man_dehyd. 1 hit.
    SUPFAMi SSF51658. SSF51658. 1 hit.
    TIGRFAMsi TIGR00695. uxuA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
      Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
      Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: IL1403.

    Entry informationi

    Entry nameiUXUA_LACLA
    AccessioniPrimary (citable) accession number: Q9CF50
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 6, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3