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Protein

Mannonate dehydratase

Gene

uxuA

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dehydration of D-mannonate.UniRule annotation

Catalytic activityi

D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O.UniRule annotation

Cofactori

Fe2+UniRule annotation, Mn2+UniRule annotation

Pathwayi

GO - Molecular functioni

  1. mannonate dehydratase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glucuronate catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Iron, Manganese

Enzyme and pathway databases

BioCyciLLAC272623:GHSH-1731-MONOMER.
UniPathwayiUPA00246.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannonate dehydrataseUniRule annotation (EC:4.2.1.8UniRule annotation)
Alternative name(s):
D-mannonate hydro-lyaseUniRule annotation
Gene namesi
Name:uxuAUniRule annotation
Ordered Locus Names:LL1631
ORF Names:L0020
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
ProteomesiUP000002196 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358Mannonate dehydratasePRO_0000170676Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272623.L0020.

Structurei

3D structure databases

ProteinModelPortaliQ9CF50.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mannonate dehydratase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1312.
KOiK01686.
OMAiEGDVDMY.
OrthoDBiEOG6ZSP6Z.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00106. UxuA.
InterProiIPR004628. Man_deHydtase.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PfamiPF03786. UxuA. 1 hit.
[Graphical view]
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR00695. uxuA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CF50-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMTMRWFGS NADKIKLSEI AQVPGVKGVV GMIMDIPAGE IWPKERIKAL
60 70 80 90 100
KEEIEAAGLT LKVIESVNIH DDIKIGLPTR DKYIENYKET IRNLAEFGIE
110 120 130 140 150
VICYNFMPVF DWLKSDLDYR LADNSQTMAF VARDIPANPQ EIIDRVQAAD
160 170 180 190 200
GCFSLPGWEP ERLSEVRGLF EAYKNVDEHK LRENFAYFLK AIIPTCEEVG
210 220 230 240 250
IKMAVHPDDP PYPMFGLPRV VKNREDLDWI CNVVDSPSNA ITLCTGSIAE
260 270 280 290 300
DPANNVYEIM AEFVKRDRIP FAHVRNIKFL PSGKKDFYEA PHMSKYGSLD
310 320 330 340 350
MYKIMKAMYD NGFDGYIRPD HGRMIWGETG RPGYGLYDRA LGASYLNGLW

EALEKTNQ
Length:358
Mass (Da):40,826
Last modified:May 31, 2001 - v1
Checksum:iFD30ABEDEC5C5CE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005176 Genomic DNA. Translation: AAK05729.1.
PIRiG86828.
RefSeqiNP_267787.1. NC_002662.1.
WP_010906067.1. NC_002662.1.

Genome annotation databases

EnsemblBacteriaiAAK05729; AAK05729; L0020.
GeneIDi1115291.
KEGGilla:L0020.
PATRICi22295690. VBILacLac136773_1752.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005176 Genomic DNA. Translation: AAK05729.1.
PIRiG86828.
RefSeqiNP_267787.1. NC_002662.1.
WP_010906067.1. NC_002662.1.

3D structure databases

ProteinModelPortaliQ9CF50.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272623.L0020.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK05729; AAK05729; L0020.
GeneIDi1115291.
KEGGilla:L0020.
PATRICi22295690. VBILacLac136773_1752.

Phylogenomic databases

eggNOGiCOG1312.
KOiK01686.
OMAiEGDVDMY.
OrthoDBiEOG6ZSP6Z.

Enzyme and pathway databases

UniPathwayiUPA00246.
BioCyciLLAC272623:GHSH-1731-MONOMER.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00106. UxuA.
InterProiIPR004628. Man_deHydtase.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PfamiPF03786. UxuA. 1 hit.
[Graphical view]
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR00695. uxuA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
    Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
    Genome Res. 11:731-753(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IL1403.

Entry informationi

Entry nameiUXUA_LACLA
AccessioniPrimary (citable) accession number: Q9CF50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 5, 2002
Last sequence update: May 31, 2001
Last modified: March 31, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.