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Q9CF50 (UXUA_LACLA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mannonate dehydratase

EC=4.2.1.8
Alternative name(s):
D-mannonate hydro-lyase
Gene names
Name:uxuA
Ordered Locus Names:LL1631
ORF Names:L0020
OrganismLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis) [Reference proteome] [HAMAP]
Taxonomic identifier272623 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus

Protein attributes

Sequence length358 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dehydration of D-mannonate By similarity. HAMAP-Rule MF_00106

Catalytic activity

D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. HAMAP-Rule MF_00106

Cofactor

Fe2+ or Mn2+ ion By similarity. HAMAP-Rule MF_00106

Pathway

Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP-Rule MF_00106

Sequence similarities

Belongs to the mannonate dehydratase family.

Ontologies

Keywords
   LigandIron
Manganese
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglucuronate catabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionmannonate dehydratase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 358358Mannonate dehydratase HAMAP-Rule MF_00106
PRO_0000170676

Sequences

Sequence LengthMass (Da)Tools
Q9CF50 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: FD30ABEDEC5C5CE4

FASTA35840,826
        10         20         30         40         50         60 
MEMTMRWFGS NADKIKLSEI AQVPGVKGVV GMIMDIPAGE IWPKERIKAL KEEIEAAGLT 

        70         80         90        100        110        120 
LKVIESVNIH DDIKIGLPTR DKYIENYKET IRNLAEFGIE VICYNFMPVF DWLKSDLDYR 

       130        140        150        160        170        180 
LADNSQTMAF VARDIPANPQ EIIDRVQAAD GCFSLPGWEP ERLSEVRGLF EAYKNVDEHK 

       190        200        210        220        230        240 
LRENFAYFLK AIIPTCEEVG IKMAVHPDDP PYPMFGLPRV VKNREDLDWI CNVVDSPSNA 

       250        260        270        280        290        300 
ITLCTGSIAE DPANNVYEIM AEFVKRDRIP FAHVRNIKFL PSGKKDFYEA PHMSKYGSLD 

       310        320        330        340        350 
MYKIMKAMYD NGFDGYIRPD HGRMIWGETG RPGYGLYDRA LGASYLNGLW EALEKTNQ 

« Hide

References

[1]"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IL1403.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE005176 Genomic DNA. Translation: AAK05729.1.
PIRG86828.
RefSeqNP_267787.1. NC_002662.1.

3D structure databases

ProteinModelPortalQ9CF50.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272623.L0020.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK05729; AAK05729; L0020.
GeneID1115291.
KEGGlla:L0020.
PATRIC22295690. VBILacLac136773_1752.

Phylogenomic databases

eggNOGCOG1312.
KOK01686.
OMARQIPGIY.
OrthoDBEOG6ZSP6Z.

Enzyme and pathway databases

BioCycLLAC272623:GHSH-1731-MONOMER.
UniPathwayUPA00246.

Family and domain databases

Gene3D3.20.20.150. 1 hit.
HAMAPMF_00106. UxuA.
InterProIPR004628. Man_deHydtase.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PfamPF03786. UxuA. 1 hit.
[Graphical view]
PIRSFPIRSF016049. Man_dehyd. 1 hit.
SUPFAMSSF51658. SSF51658. 1 hit.
TIGRFAMsTIGR00695. uxuA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUXUA_LACLA
AccessionPrimary (citable) accession number: Q9CF50
Entry history
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: June 1, 2001
Last modified: May 14, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways