Q9CF39 (AROD_LACLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-dehydroquinate dehydratase
Short name=3-dehydroquinase
EC=4.2.1.10

Alternative name(s):
Type I DHQase

Gene names

Name:	aroD
Ordered Locus Names:	LL1642
ORF Names:	L0062

Organism

Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)

Taxonomic identifier

272623 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus

Protein attributes

Sequence length	226 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP MF_00214
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP MF_00214
Subunit structure	Homodimer By similarity. HAMAP MF_00214
Sequence similarities	Belongs to the type-I 3-dehydroquinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-dehydroquinate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 226	226	3-dehydroquinate dehydratase HAMAP MF_00214		PRO_0000138797
Sites
	Active site	121	1	Proton acceptor By similarity
	Active site	146	1	Schiff-base intermediate with substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9CF39 [UniParc]. Last modified April 27, 2001. Version 1. Checksum: F6D97B3098E7F5F1	FASTA	226	25,974
	10 20 30 40 50 60 MRKTKIVVPI MLTELAELEK VSVSDYRTAD IVEWRADFLS ADEILEMAPK FFEKFKESKI 70 80 90 100 110 120 LFTLRTVREG GNIQVSEKKY LQILKEILTY NPAYIDVEFF THGPSFAALK DFRDKMVLSY 130 140 150 160 170 180 HNFDEVPSDL TNRLIKMHEE GTAFVKVAVM PERECDVLDL LQITRDMTLE YGDHFISMAM 190 200 210 220 GDLGRLSRIS GYLTGSCWTF ASLENSSAPG QISLKETEYI LDILEK

References

[1]	"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403." Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A. Genome Res. 11:731-753(2001) [PubMed: 11337471] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IL1403.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005176 Genomic DNA. Translation: AAK05740.1.
PIR	B86830.
RefSeq	NP_267798.1. NC_002662.1.
3D structure databases
ProteinModelPortal	Q9CF39.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1115302.
GenomeReviews	Gene locus LL1642 in contig AE005176_GR.
KEGG	lla:L0062.
NMPDR	fig|272623.1.peg.1684.
PATRIC	22295714. VBILacLac136773_1764.
Phylogenomic databases
HOGENOM	HBG732926.
OMA	SYHNFDE.
ProtClustDB	PRK02412.
Enzyme and pathway databases
BioCyc	LLAC272623:L0062-MONOMER.
Family and domain databases
HAMAP	MF_00214. AroD. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR001381. DHquinase_I. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K03785.
Pfam	PF01487. DHquinase_I. 1 hit. [Graphical view]
TIGRFAMs	TIGR01093. AroD. 1 hit.
PROSITE	PS01028. DEHYDROQUINASE_I. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROD_LACLA

Accession

Primary (citable) accession number: Q9CF39

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	April 27, 2001
Last modified:	January 25, 2012
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program