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Protein

Uridine kinase

Gene

udk

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + uridine = ADP + UMP.UniRule annotation
ATP + cytidine = ADP + CMP.UniRule annotation

Pathwayi: CTP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes CTP from cytidine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Uridine kinase (udk)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway CTP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CTP from cytidine, the pathway CTP biosynthesis via salvage pathway and in Pyrimidine metabolism.

Pathwayi: UMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes UMP from uridine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Uridine kinase (udk)
This subpathway is part of the pathway UMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from uridine, the pathway UMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 18ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLLAC272623:G1FZA-1745-MONOMER
UniPathwayiUPA00574; UER00637
UPA00579; UER00640

Names & Taxonomyi

Protein namesi
Recommended name:
Uridine kinaseUniRule annotation (EC:2.7.1.48UniRule annotation)
Alternative name(s):
Cytidine monophosphokinaseUniRule annotation
Uridine monophosphokinaseUniRule annotation
Gene namesi
Name:udkUniRule annotation
Ordered Locus Names:LL1660
ORF Names:L108994
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
Proteomesi
  • UP000002196 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001644751 – 206Uridine kinaseAdd BLAST206

Proteomic databases

PaxDbiQ9CF21

Interactioni

Protein-protein interaction databases

STRINGi272623.L108994

Structurei

3D structure databases

ProteinModelPortaliQ9CF21
SMRiQ9CF21
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uridine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DBI Bacteria
COG0572 LUCA
HOGENOMiHOG000262756
KOiK00876
OMAiTTLKPMH

Family and domain databases

CDDicd02023 UMPK, 1 hit
HAMAPiMF_00551 Uridine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR006083 PRK/URK
IPR000764 Uridine_kinase-like
IPR026008 Uridine_kinase_
PfamiView protein in Pfam
PF00485 PRK, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00235 udk, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CF21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKTLIIGVT GGSASGKTSV SHAILETFSN ERIAMIEHDS YYKDQSHLTF
60 70 80 90 100
EERTKTNYDH PLAFDTDYLI AQLKELQYGR AVDIPIYDYA KHTRSQETYR
110 120 130 140 150
QEPVDVLIVE GILVLEDERL RDLMDIKIFV DTDDDVRIIR RIRRDIEERG
160 170 180 190 200
RTLDSVITQY LDAVKPMYHQ FIEPTKRYAD VIIPEGVSNT VGVDIITTKI

ASILND
Length:206
Mass (Da):23,740
Last modified:June 1, 2001 - v1
Checksum:i82E38F052037DBEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005176 Genomic DNA Translation: AAK05758.1
PIRiD86832
RefSeqiNP_267816.1, NC_002662.1
WP_010906081.1, NC_002662.1

Genome annotation databases

EnsemblBacteriaiAAK05758; AAK05758; L108994
GeneIDi1115320
KEGGilla:L108994
PATRICifig|272623.7.peg.1781

Similar proteinsi

Entry informationi

Entry nameiURK_LACLA
AccessioniPrimary (citable) accession number: Q9CF21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: June 1, 2001
Last modified: February 28, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome