Q9CEU2 (PHEA_LACLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Prephenate dehydratase
Short name=PDT
EC=4.2.1.51

Gene names

Name:	pheA
Ordered Locus Names:	LL1742
ORF Names:	L0055

Organism

Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)

Taxonomic identifier

272623 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus

Protein attributes

Sequence length	279 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Catalytic activity	Prephenate = phenylpyruvate + H2O + CO2.
Pathway	Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.
Sequence similarities	Contains 1 ACT domain. Contains 1 prephenate dehydratase domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Phenylalanine biosynthesis
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	L-phenylalanine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	prephenate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 279	279	Prephenate dehydratase		PRO_0000119178
Regions
	Domain	2 – 178	177	Prephenate dehydratase
	Domain	192 – 268	77	ACT
Sites
	Site	171	1	Essential for activity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9CEU2 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 0F2A839340C69AFC	FASTA	279	30,966
	10 20 30 40 50 60 MKIAYLGPRG SFCSVVAETA FVSEELFAYD SILDVIEAYD EGKCDFALVP IENSTEGTVN 70 80 90 100 110 120 MSIDKIFHDS KATVVAEFVL PISQNLLALS KEGKIEHIYS HPQALAQTRN YLREHYPQAK 130 140 150 160 170 180 VEITDSTSAA AEFVKNHPDL PIAAVANSYA AKMYDLEIVA KNIQDLAGNS TRFWLLGKEK 190 200 210 220 230 240 KSFDLLKTGE KVSLALTLPD NLPGALHKAI SVFAWRDIDM TKIESRPLRT RLGQYFFNID 250 260 270 LVNNEKNNLK IPYALEELSG LGVKVRLLGN YAVYSLGEG

References

[1]

"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403." Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A. Genome Res. 11:731-753(2001) [PubMed: 11337471] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IL1403.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005176 Genomic DNA. Translation: AAK05840.1.
PIR	F86842.
RefSeq	NP_267898.1. NC_002662.1.
3D structure databases
ProteinModelPortal	Q9CEU2.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1115405.
GenomeReviews	Gene locus LL1742 in contig AE005176_GR.
KEGG	lla:L0055.
NMPDR	fig|272623.1.peg.1786.
PATRIC	22295926. VBILacLac136773_1868.
Phylogenomic databases
HOGENOM	HBG693866.
OMA	CRKWLDA.
ProtClustDB	PRK11898.
Enzyme and pathway databases
BioCyc	LLAC272623:L0055-MONOMER.
Family and domain databases
InterPro	IPR001086. Preph_deHydtase. IPR018528. Preph_deHydtase_CS. [Graphical view]
KO	K04518.
Pfam	PF00800. PDT. 1 hit. [Graphical view]
PROSITE	PS00857. PREPHENATE_DEHYDR_1. 1 hit. PS00858. PREPHENATE_DEHYDR_2. 1 hit. PS51171. PREPHENATE_DEHYDR_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PHEA_LACLA

Accession

Primary (citable) accession number: Q9CEU2

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	June 1, 2001
Last modified:	January 25, 2012
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program