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Q9CET9 (TYRA_LACLA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Prephenate dehydrogenase

Short name=PDH
EC=1.3.1.12
Gene names
Name:tyrA
Ordered Locus Names:LL1745
ORF Names:L0058
OrganismLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis) [Reference proteome] [HAMAP]
Taxonomic identifier272623 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus

Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Protein existencePredicted

General annotation (Comments)

Catalytic activity

Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.

Pathway

Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route): step 1/1.

Sequence similarities

Contains 1 ACT domain.

Contains 1 prephenate/arogenate dehydrogenase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 354354Prephenate dehydrogenase
PRO_0000119193

Regions

Domain2 – 283282Prephenate/arogenate dehydrogenase
Domain287 – 35468ACT
Nucleotide binding3 – 3331NAD Potential

Sequences

Sequence LengthMass (Da)Tools
Q9CET9 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 766A20C932A627E2

FASTA35439,496
        10         20         30         40         50         60 
MKKILIIGLG LIGSSIALGI KRAHPDFEIL GSDRENIQEI AQKRGIIDSK VSLVEGAQKA 

        70         80         90        100        110        120 
DIIILAVPII TTLELLKKLA TLNLKKGLLI TDTGSTKSEI VELANQLFDE DKVRFIGGHP 

       130        140        150        160        170        180 
MAGSHKSGVM AADINLFENA YYVLTQENQE LRDLLKGLHA KFIILDAKEH DRVTGQVSHF 

       190        200        210        220        230        240 
PHILASALVW QSDDFSKEHP LVKHLAAGGF RDLTRIAEAD SLMWTSVLLS NPEITIDRIE 

       250        260        270        280        290        300 
NFKKQLDEIA LKIANKDSAA IEHFFEQGKK IRQAMEIHKG ALPNFYDLFI SVPDEKGVVL 

       310        320        330        340        350 
KVLGLLEDFS ITNVKINEEN REDIHGQLQI SFKRAEDLKE AREIIEKATD FTVV 

« Hide

References

[1]"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IL1403.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE005176 Genomic DNA. Translation: AAK05843.1.
PIRA86843.
RefSeqNP_267901.1. NC_002662.1.

3D structure databases

ProteinModelPortalQ9CET9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272623.L0058.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK05843; AAK05843; L0058.
GeneID1115408.
KEGGlla:L0058.
PATRIC22295932. VBILacLac136773_1871.

Phylogenomic databases

eggNOGCOG0287.
HOGENOMHOG000043494.
KOK04517.
OMAHAMAGTH.
OrthoDBEOG6B8XMB.

Enzyme and pathway databases

BioCycLLAC272623:GHSH-1850-MONOMER.
UniPathwayUPA00122; UER00961.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR002912. ACT_dom.
IPR016040. NAD(P)-bd_dom.
IPR003099. Prephen_DH.
[Graphical view]
PfamPF02153. PDH. 1 hit.
[Graphical view]
SUPFAMSSF48179. SSF48179. 1 hit.
PROSITEPS51671. ACT. 1 hit.
PS51176. PDH_ADH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYRA_LACLA
AccessionPrimary (citable) accession number: Q9CET9
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: May 14, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways