Reviewed, UniProtKB/Swiss-Prot Q9CET9 (TYRA_LACLA)

Names and origin

Protein names

Recommended name:
    Prephenate dehydrogenase
      Short name=PDH
    EC=1.3.1.12

Gene names

Name:	tyrA
Ordered Locus Names:	LL1745
ORF Names:	L0058

Organism

Lactococcus lactis subsp. lactis (Streptococcus lactis) [Complete proteome] [HAMAP]

Taxonomic identifier

1360 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus

Protein attributes

Sequence length	354 AA.
Sequence status	Complete.
Protein existence	Predicted.

General annotation (Comments)

Catalytic activity	Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.
Pathway	Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route): step 1/1.
Sequence similarities	Contains 1 ACT domain. Contains 1 prephenate/arogenate dehydrogenase domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tyrosine biosynthesis
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tyrosine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro prephenate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: InterPro prephenate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 354	354	Prephenate dehydrogenase		PRO_0000119193
Regions
	Domain	2 – 283	282	Prephenate/arogenate dehydrogenase
	Domain	286 – 354	69	ACT
	Nucleotide binding	3 – 33	31	NAD Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9CET9-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 766A20C932A627E2	FASTA	354	39,496
	10 20 30 40 50 60 MKKILIIGLG LIGSSIALGI KRAHPDFEIL GSDRENIQEI AQKRGIIDSK VSLVEGAQKA 70 80 90 100 110 120 DIIILAVPII TTLELLKKLA TLNLKKGLLI TDTGSTKSEI VELANQLFDE DKVRFIGGHP 130 140 150 160 170 180 MAGSHKSGVM AADINLFENA YYVLTQENQE LRDLLKGLHA KFIILDAKEH DRVTGQVSHF 190 200 210 220 230 240 PHILASALVW QSDDFSKEHP LVKHLAAGGF RDLTRIAEAD SLMWTSVLLS NPEITIDRIE 250 260 270 280 290 300 NFKKQLDEIA LKIANKDSAA IEHFFEQGKK IRQAMEIHKG ALPNFYDLFI SVPDEKGVVL 310 320 330 340 350 KVLGLLEDFS ITNVKINEEN REDIHGQLQI SFKRAEDLKE AREIIEKATD FTVV

References

[1]

"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403." Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A. Genome Res. 11:731-753(2001) [PubMed: 11337471] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IL1403.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005176 Genomic DNA. Translation: AAK05843.1.
PIR	A86843.
RefSeq	NP_267901.1.
3D structure databases
SMR	Q9CET9. Positions 3-275.
ModBase	Search...
Genome annotation databases
GeneID	1115408.
GenomeReviews	Gene locus LL1745 in contig AE005176_GR.
KEGG	lla:L0058.
NMPDR	fig|272623.1.peg.1789.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG544990.
OMA	QRAIRWG.
Enzyme and pathway databases
BioCyc	LLAC272623:L0058-MONOMER.
BRENDA	1.3.1.12. 278870.
Family and domain databases
InterPro	IPR016040. NAD(P)-bd_dom. IPR003099. Prephen_DH. [Graphical view]
PANTHER	PTHR21363. Prephen_DH. 1 hit.
Pfam	PF02153. PDH. 1 hit. [Graphical view]
PROSITE	PS51176. PDH_ADH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYRA_LACLA

Accession

Primary (citable) accession number: Q9CET9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	June 1, 2001
Last modified:	January 19, 2010
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)