Q9CES7 (AROE_LACLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase
EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	LL1757
ORF Names:	L0061

Organism

Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)

Taxonomic identifier

272623 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus

Protein attributes

Sequence length	286 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 286	286	Shikimate dehydrogenase HAMAP MF_00222		PRO_0000136009
Regions
	Nucleotide binding	131 – 135	5	NADP By similarity
Sites
	Active site	71	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9CES7 [UniParc]. Last modified April 27, 2001. Version 1. Checksum: B2429395E5A9A82B	FASTA	286	31,204
	10 20 30 40 50 60 MNINGYTRMA AVVANPIKHS LSPFIHNLAF DLTNENGVYL AWEVEAEKLP AIVDNVRTLD 70 80 90 100 110 120 MYGLNISMPY KTEITPFMDE LSPAAELIGA VNTVVNQSGK LIGHNTDGIG FFNSLEKYHF 130 140 150 160 170 180 NIQNKQMLIL GGGGAAIAII AQAALSGAKK IVVAARKSAS YIPLKEKLEK LSVKTGIEIL 190 200 210 220 230 240 LTDLSEADRL QKELKQTDLL VNATSVGMDG ESLPLEKSLV LPEKLLVVDA IYKVRETPFL 250 260 270 280 RWAKGQGAQT ENGLGMLIGQ AAESFYLWTG KKMPVAEITL EMEKEA

References

[1]

"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403." Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A. Genome Res. 11:731-753(2001) [PubMed: 11337471] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IL1403.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005176 Genomic DNA. Translation: AAK05855.1.
PIR	E86844.
RefSeq	NP_267913.1. NC_002662.1.
3D structure databases
ProteinModelPortal	Q9CES7.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1115420.
GenomeReviews	Gene locus LL1757 in contig AE005176_GR.
KEGG	lla:L0061.
NMPDR	fig|272623.1.peg.1801.
PATRIC	22295956. VBILacLac136773_1883.
Phylogenomic databases
HOGENOM	HBG553408.
OMA	AVNTIVH.
ProtClustDB	PRK00258.
Enzyme and pathway databases
BioCyc	LLAC272623:L0061-MONOMER.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_LACLA

Accession

Primary (citable) accession number: Q9CES7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	April 27, 2001
Last modified:	January 25, 2012
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program