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Q9CEF5

- PKNB_LACLA

UniProt

Q9CEF5 - PKNB_LACLA

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Protein

Probable serine/threonine-protein kinase PknB

Gene

pknB

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421ATPPROSITE-ProRule annotation
Active sitei136 – 1361Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 269ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. penicillin binding Source: InterPro
  3. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLLAC272623:GHSH-1994-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable serine/threonine-protein kinase PknB (EC:2.7.11.1)
Gene namesi
Name:pknB
Ordered Locus Names:LL1887
ORF Names:L138452
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
ProteomesiUP000002196: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 627627Probable serine/threonine-protein kinase PknBPRO_0000171200Add
BLAST

PTM databases

PhosSiteiP0810478.

Interactioni

Protein-protein interaction databases

STRINGi272623.L138452.

Structurei

3D structure databases

ProteinModelPortaliQ9CEF5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 275264Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini361 – 42868PASTA 1PROSITE-ProRule annotationAdd
BLAST
Domaini430 – 50273PASTA 2PROSITE-ProRule annotationAdd
BLAST
Domaini503 – 57472PASTA 3PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi579 – 62749Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 3 PASTA domains.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000037186.
KOiK08884.
OMAiMSKNPAN.
OrthoDBiEOG6B35XT.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR005543. PASTA_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF03793. PASTA. 3 hits.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00740. PASTA. 3 hits.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS51178. PASTA. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CEF5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIQIGKIFAD RYRIIKEIGR GGMANVYQGE DTFLGDRLVA IKVLRSNFEN
60 70 80 90 100
DDIAIARFQR EAFAMAELSH PNIVGISDVG EFESQQYIVM EFVDGMTLKQ
110 120 130 140 150
YINQNAPLAN DEAIEIITEI LSAMDMAHSH GIIHRDLKPQ NVLVSSSGTV
160 170 180 190 200
KVTDFGIAKA LSETSLTQTN TMFGSVHYLS PEQARGSNAT VQSDIYAIGI
210 220 230 240 250
ILFELLTGQI PFDGDSAVAI ALKHFQESIP SIINLNPEVP QALENVVIKA
260 270 280 290 300
TAKDIKNRYT DVEEMMTDVA TSTSLDRRGE EKLVFNKDHD ETKIMPANLI
310 320 330 340 350
NPYDTKPLID KKEDNDSQTD EKAASSEVGN KNKKSKKGLI IGLIILLLVV
360 370 380 390 400
GGATLAWVVS TPTNVKIPNV TNSTLSQAKS KIKDAKLKVG TVHKQQSSTI
410 420 430 440 450
AEGKVIKTDP TSGTTVRSNS SVDIYVSTGN EDIIKMKDFV GEKIDEAMAT
460 470 480 490 500
LLKDYGIDES QVTQTSVPSD SYPAGTIIKQ SPKKGSSFDT KGSEKITFEV
510 520 530 540 550
SSGKQVEVPD YKPNGQYMTY SQYQAALKAA GFTNITLDPQ ATTNQQADGY
560 570 580 590 600
VYSVYPNVGT SVDPTQEIVV TYSVYTAPSS SSTTSESTTT SETSSSTTSS
610 620
TSSSTTSQPS TDNNNSSKES STTSSSS
Length:627
Mass (Da):67,878
Last modified:June 1, 2001 - v1
Checksum:i00B30B68C5C28A81
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005176 Genomic DNA. Translation: AAK05985.1.
PIRiG86860.
RefSeqiNP_268044.1. NC_002662.1.

Genome annotation databases

EnsemblBacteriaiAAK05985; AAK05985; L138452.
GeneIDi1115552.
KEGGilla:L138452.
PATRICi22296232. VBILacLac136773_2021.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005176 Genomic DNA. Translation: AAK05985.1 .
PIRi G86860.
RefSeqi NP_268044.1. NC_002662.1.

3D structure databases

ProteinModelPortali Q9CEF5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272623.L138452.

PTM databases

PhosSitei P0810478.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK05985 ; AAK05985 ; L138452 .
GeneIDi 1115552.
KEGGi lla:L138452.
PATRICi 22296232. VBILacLac136773_2021.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000037186.
KOi K08884.
OMAi MSKNPAN.
OrthoDBi EOG6B35XT.

Enzyme and pathway databases

BioCyci LLAC272623:GHSH-1994-MONOMER.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR005543. PASTA_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF03793. PASTA. 3 hits.
PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00740. PASTA. 3 hits.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 2 hits.
PROSITEi PS51178. PASTA. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
    Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
    Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IL1403.

Entry informationi

Entry nameiPKNB_LACLA
AccessioniPrimary (citable) accession number: Q9CEF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2003
Last sequence update: June 1, 2001
Last modified: October 1, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3