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Protein

Probable serine/threonine-protein kinase PknB

Gene

pknB

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei42ATPPROSITE-ProRule annotation1
Active sitei136Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 26ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable serine/threonine-protein kinase PknB (EC:2.7.11.1)
Gene namesi
Name:pknB
Ordered Locus Names:LL1887
ORF Names:L138452
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
Proteomesi
  • UP000002196 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001712001 – 627Probable serine/threonine-protein kinase PknBAdd BLAST627

Proteomic databases

PaxDbiQ9CEF5.

Interactioni

Protein-protein interaction databases

STRINGi272623.L138452.

Structurei

3D structure databases

ProteinModelPortaliQ9CEF5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 275Protein kinasePROSITE-ProRule annotationAdd BLAST264
Domaini361 – 428PASTA 1PROSITE-ProRule annotationAdd BLAST68
Domaini430 – 502PASTA 2PROSITE-ProRule annotationAdd BLAST73
Domaini503 – 574PASTA 3PROSITE-ProRule annotationAdd BLAST72

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi579 – 627Ser-richAdd BLAST49

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 3 PASTA domains.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105D9P. Bacteria.
COG0515. LUCA.
COG2815. LUCA.
HOGENOMiHOG000037186.
KOiK12132.
OMAiIRMYIND.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR005543. PASTA_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF03793. PASTA. 3 hits.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00740. PASTA. 3 hits.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS51178. PASTA. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CEF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQIGKIFAD RYRIIKEIGR GGMANVYQGE DTFLGDRLVA IKVLRSNFEN
60 70 80 90 100
DDIAIARFQR EAFAMAELSH PNIVGISDVG EFESQQYIVM EFVDGMTLKQ
110 120 130 140 150
YINQNAPLAN DEAIEIITEI LSAMDMAHSH GIIHRDLKPQ NVLVSSSGTV
160 170 180 190 200
KVTDFGIAKA LSETSLTQTN TMFGSVHYLS PEQARGSNAT VQSDIYAIGI
210 220 230 240 250
ILFELLTGQI PFDGDSAVAI ALKHFQESIP SIINLNPEVP QALENVVIKA
260 270 280 290 300
TAKDIKNRYT DVEEMMTDVA TSTSLDRRGE EKLVFNKDHD ETKIMPANLI
310 320 330 340 350
NPYDTKPLID KKEDNDSQTD EKAASSEVGN KNKKSKKGLI IGLIILLLVV
360 370 380 390 400
GGATLAWVVS TPTNVKIPNV TNSTLSQAKS KIKDAKLKVG TVHKQQSSTI
410 420 430 440 450
AEGKVIKTDP TSGTTVRSNS SVDIYVSTGN EDIIKMKDFV GEKIDEAMAT
460 470 480 490 500
LLKDYGIDES QVTQTSVPSD SYPAGTIIKQ SPKKGSSFDT KGSEKITFEV
510 520 530 540 550
SSGKQVEVPD YKPNGQYMTY SQYQAALKAA GFTNITLDPQ ATTNQQADGY
560 570 580 590 600
VYSVYPNVGT SVDPTQEIVV TYSVYTAPSS SSTTSESTTT SETSSSTTSS
610 620
TSSSTTSQPS TDNNNSSKES STTSSSS
Length:627
Mass (Da):67,878
Last modified:June 1, 2001 - v1
Checksum:i00B30B68C5C28A81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005176 Genomic DNA. Translation: AAK05985.1.
PIRiG86860.
RefSeqiNP_268044.1. NC_002662.1.
WP_003130801.1. NC_002662.1.

Genome annotation databases

EnsemblBacteriaiAAK05985; AAK05985; L138452.
GeneIDi1115552.
KEGGilla:L138452.
PATRICi22296232. VBILacLac136773_2021.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005176 Genomic DNA. Translation: AAK05985.1.
PIRiG86860.
RefSeqiNP_268044.1. NC_002662.1.
WP_003130801.1. NC_002662.1.

3D structure databases

ProteinModelPortaliQ9CEF5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272623.L138452.

Proteomic databases

PaxDbiQ9CEF5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK05985; AAK05985; L138452.
GeneIDi1115552.
KEGGilla:L138452.
PATRICi22296232. VBILacLac136773_2021.

Phylogenomic databases

eggNOGiENOG4105D9P. Bacteria.
COG0515. LUCA.
COG2815. LUCA.
HOGENOMiHOG000037186.
KOiK12132.
OMAiIRMYIND.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR005543. PASTA_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF03793. PASTA. 3 hits.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00740. PASTA. 3 hits.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS51178. PASTA. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPKNB_LACLA
AccessioniPrimary (citable) accession number: Q9CEF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2003
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.