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Q9CEF5

- PKNB_LACLA

UniProt

Q9CEF5 - PKNB_LACLA

Protein

Probable serine/threonine-protein kinase PknB

Gene

pknB

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei42 – 421ATPPROSITE-ProRule annotation
    Active sitei136 – 1361Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi18 – 269ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. penicillin binding Source: InterPro
    3. protein serine/threonine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLLAC272623:GHSH-1994-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable serine/threonine-protein kinase PknB (EC:2.7.11.1)
    Gene namesi
    Name:pknB
    Ordered Locus Names:LL1887
    ORF Names:L138452
    OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
    Taxonomic identifieri272623 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
    ProteomesiUP000002196: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 627627Probable serine/threonine-protein kinase PknBPRO_0000171200Add
    BLAST

    PTM databases

    PhosSiteiP0810478.

    Interactioni

    Protein-protein interaction databases

    STRINGi272623.L138452.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CEF5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini12 – 275264Protein kinasePROSITE-ProRule annotationAdd
    BLAST
    Domaini361 – 42868PASTA 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini430 – 50273PASTA 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini503 – 57472PASTA 3PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi579 – 62749Ser-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 3 PASTA domains.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000037186.
    KOiK08884.
    OMAiMSKNPAN.
    OrthoDBiEOG6B35XT.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR005543. PASTA_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF03793. PASTA. 3 hits.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00740. PASTA. 3 hits.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 2 hits.
    PROSITEiPS51178. PASTA. 3 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9CEF5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIQIGKIFAD RYRIIKEIGR GGMANVYQGE DTFLGDRLVA IKVLRSNFEN    50
    DDIAIARFQR EAFAMAELSH PNIVGISDVG EFESQQYIVM EFVDGMTLKQ 100
    YINQNAPLAN DEAIEIITEI LSAMDMAHSH GIIHRDLKPQ NVLVSSSGTV 150
    KVTDFGIAKA LSETSLTQTN TMFGSVHYLS PEQARGSNAT VQSDIYAIGI 200
    ILFELLTGQI PFDGDSAVAI ALKHFQESIP SIINLNPEVP QALENVVIKA 250
    TAKDIKNRYT DVEEMMTDVA TSTSLDRRGE EKLVFNKDHD ETKIMPANLI 300
    NPYDTKPLID KKEDNDSQTD EKAASSEVGN KNKKSKKGLI IGLIILLLVV 350
    GGATLAWVVS TPTNVKIPNV TNSTLSQAKS KIKDAKLKVG TVHKQQSSTI 400
    AEGKVIKTDP TSGTTVRSNS SVDIYVSTGN EDIIKMKDFV GEKIDEAMAT 450
    LLKDYGIDES QVTQTSVPSD SYPAGTIIKQ SPKKGSSFDT KGSEKITFEV 500
    SSGKQVEVPD YKPNGQYMTY SQYQAALKAA GFTNITLDPQ ATTNQQADGY 550
    VYSVYPNVGT SVDPTQEIVV TYSVYTAPSS SSTTSESTTT SETSSSTTSS 600
    TSSSTTSQPS TDNNNSSKES STTSSSS 627
    Length:627
    Mass (Da):67,878
    Last modified:June 1, 2001 - v1
    Checksum:i00B30B68C5C28A81
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005176 Genomic DNA. Translation: AAK05985.1.
    PIRiG86860.
    RefSeqiNP_268044.1. NC_002662.1.

    Genome annotation databases

    EnsemblBacteriaiAAK05985; AAK05985; L138452.
    GeneIDi1115552.
    KEGGilla:L138452.
    PATRICi22296232. VBILacLac136773_2021.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005176 Genomic DNA. Translation: AAK05985.1 .
    PIRi G86860.
    RefSeqi NP_268044.1. NC_002662.1.

    3D structure databases

    ProteinModelPortali Q9CEF5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272623.L138452.

    PTM databases

    PhosSitei P0810478.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK05985 ; AAK05985 ; L138452 .
    GeneIDi 1115552.
    KEGGi lla:L138452.
    PATRICi 22296232. VBILacLac136773_2021.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000037186.
    KOi K08884.
    OMAi MSKNPAN.
    OrthoDBi EOG6B35XT.

    Enzyme and pathway databases

    BioCyci LLAC272623:GHSH-1994-MONOMER.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR005543. PASTA_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF03793. PASTA. 3 hits.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00740. PASTA. 3 hits.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 2 hits.
    PROSITEi PS51178. PASTA. 3 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
      Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
      Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: IL1403.

    Entry informationi

    Entry nameiPKNB_LACLA
    AccessioniPrimary (citable) accession number: Q9CEF5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2003
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3