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Q9CEE9 (FMT_LACLA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Methionyl-tRNA formyltransferase
EC=2.1.2.9
Gene names
Name:fmt
Ordered Locus Names:LL1893
ORF Names:L0362
OrganismLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis) [Reference proteome] [HAMAP]
Taxonomic identifier272623 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Lactococcus ›

Protein attributes

Sequence length319 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP By similarity. HAMAP-Rule MF_00182

Catalytic activity

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet). HAMAP-Rule MF_00182

Sequence similarities

Belongs to the Fmt family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranslational initiation

Inferred from electronic annotation. Source: GOC

   Molecular_functionmethionyl-tRNA formyltransferase activity

Inferred from electronic annotation. Source: HAMAP

methyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 319319Methionyl-tRNA formyltransferase HAMAP-Rule MF_00182
PRO_0000082979

Regions

Region115 – 1184Tetrahydrofolate (THF) binding By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9CEE9 [UniParc].

Last modified April 27, 2001. Version 1.
Checksum: 45325BEE1112939E

FASTA31935,081
        10         20         30         40         50         60 
MTKTKIIFMG TPQFAATVLK GLIDSNQYEI LAVVTQPDRK VGRKQELRMT PVKELALTVN 

        70         80         90        100        110        120 
LPVLQPEKLS GSVEMTQIMT LLESGEVGIV TAAFGQFLPG KLLDVAQFAV NTHASLLPKY 

       130        140        150        160        170        180 
RGGAPIHYAI MNGEKEAGVT IMEMIRKMDA GDMIAQDSTP ILEDDNVGTM FEKLALVGRD 

       190        200        210        220        230        240 
LLLETLPKYL SGQLKAQAQN EDEVTFSPNI SPEEEKIDWN KSAREIFNKV RGMNPFPVAH 

       250        260        270        280        290        300 
TTWNGERFKI YETKVVDDSV GNLQAGEIVE KTKKSLKVAT GEGLLELLFV QPAGKPKMDI 

       310 
VSFLNGLGQK IQVGDKFGD

« Hide

References

[1]"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IL1403.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE005176 Genomic DNA. Translation: AAK05991.1.
PIRE86861.
RefSeqNP_268050.1. NC_002662.1.

3D structure databases

ProteinModelPortalQ9CEE9.
ModBaseSearch...

Protein-protein interaction databases

STRING272623.L0362.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK05991; AAK05991; L0362.
GeneID1115558.
KEGGlla:L0362.
PATRIC22296246. VBILacLac136773_2028.

Phylogenomic databases

eggNOGCOG0223.
HOGENOMHOG000261177.
KOK00604.
OMADWNKSAR.
ProtClustDBPRK00005.

Enzyme and pathway databases

BioCycLLAC272623:GHSH-2000-MONOMER.

Family and domain databases

Gene3D3.10.25.10. 1 hit.
3.40.50.170. 1 hit.
HAMAPMF_00182. Formyl_trans.
InterProIPR005794. Fmt.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
IPR015518. Met_tRNA_Form_TA-like.
[Graphical view]
PANTHERPTHR11138. PTHR11138. 1 hit.
PfamPF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
[Graphical view]
SUPFAMSSF50486. FMT_C_like. 1 hit.
SSF53328. formyl_transf. 1 hit.
TIGRFAMsTIGR00460. fmt. 1 hit.
PROSITEPS00373. GART. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFMT_LACLA
AccessionPrimary (citable) accession number: Q9CEE9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: May 29, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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