Q9CE63 (GALT_LACLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Galactose-1-phosphate uridylyltransferase
Short name=Gal-1-P uridylyltransferase
EC=2.7.7.12

Alternative name(s):
UDP-glucose--hexose-1-phosphate uridylyltransferase

Gene names

Name:	galT
Ordered Locus Names:	LL1982
ORF Names:	L0027

Organism

Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)

Taxonomic identifier

272623 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus

Protein attributes

Sequence length	493 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	UDP-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-galactose. HAMAP MF_00571
Pathway	Carbohydrate metabolism; galactose metabolism. HAMAP MF_00571
Subcellular location	Cytoplasm Potential HAMAP MF_00571.
Sequence similarities	Belongs to the galactose-1-phosphate uridylyltransferase type 2 family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Galactose metabolism
Cellular component	Cytoplasm
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	galactose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	UDP-glucose:hexose-1-phosphate uridylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 493	493	Galactose-1-phosphate uridylyltransferase HAMAP MF_00571		PRO_0000169908
Natural variations
	Natural variant	95	1	Q → H in strain: ATCC 7962 and NCDO 2054.
	Natural variant	128	1	T → A in strain: ATCC 7962 and NCDO 2054.
	Natural variant	435	1	K → R in strain: ATCC 7962 and NCDO 2054.

Sequences

	Sequence		Length	Mass (Da)
	Q9CE63 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 5CED96D1B89E48C2	FASTA	493	56,555
	10 20 30 40 50 60 MSIYQSIQDF ISLALQNGTI EPLDELYHRN QLLHFLGLND WAEVDKEAHE KDSLILMDQL 70 80 90 100 110 120 LAIANENNVI EKGQDEFYEA ALMNFITPRP SKINQDFWEK YKTSPDAATQ YFYELAQQVN 130 140 150 160 170 180 QVKTRDITRN IAFSHLTKYG KLEITINLSK PEKDPKAIAA AKLVKASSYP ACQLCLENEG 190 200 210 220 230 240 FYGIGNKPAR SNHRIIQVSI NGEDWGFQYS PYAYFNEHSI LLNAKHQPME INKRAFDNLL 250 260 270 280 290 300 GFLDQFPDYM IGSNADLPIV GGSILTHDHY QAGRYEFPMA KAELREEIKL QQFPEVSCGI 310 320 330 340 350 360 VNWPMSVLRL SSKNQVELSK AADELLKKWQ VYSDESLQIK AKSADGKLHH TITPIARIRE 370 380 390 400 410 420 GKYELDLVLR DNNTSEIYPD GIFHPHPALH HIKKENIGLI EVMGLAILPA RLKTELLEVE 430 440 450 460 470 480 KYLLNQENEM SEIHKPWAEE LKETEYFSKE TVHETVQEAV GEVFEQVLKD AGVFKDNEVG 490 QKGFYEFINF VNN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Transcriptional regulation and evolution of lactose genes in the galactose-lactose operon of Lactococcus lactis NCDO2054." Vaughan E.E., Pridmore R.D., Mollet B. J. Bacteriol. 180:4893-4902(1998) [PubMed: 9733693] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: NCDO 2054.
[2]	"The organization of genes involved in metabolism of gal/lac of Lactococcus lactis." Lee J.M., Chung D.K., Park J.H., Lee W.K., Chang H.C., Kim J.H., Lee H.J. Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 7962.
[3]	"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403." Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A. Genome Res. 11:731-753(2001) [PubMed: 11337471] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IL1403.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF082008 Genomic DNA. Translation: AAC63018.1. U60828 Genomic DNA. Translation: AAD11511.1. AE005176 Genomic DNA. Translation: AAK06080.1.
PIR	F86872.
RefSeq	NP_268139.1. NC_002662.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1115657.
GenomeReviews	Gene locus LL1982 in contig AE005176_GR.
KEGG	lla:L0027.
NMPDR	fig|272623.1.peg.2036.
PATRIC	22296484. VBILacLac136773_2135.
Phylogenomic databases
HOGENOM	HBG337915.
OMA	HYFIGSN.
ProtClustDB	PRK05270.
Enzyme and pathway databases
BioCyc	LLAC272623:L0027-MONOMER.
Family and domain databases
HAMAP	MF_00571. GalP_UDP_trans. [Tree]
InterPro	IPR000766. GalP_uridyl_Trfase_II. IPR023425. GalP_uridyl_Trfase_II_CS. IPR005850. GalP_Utransf_C. IPR005849. GalP_Utransf_N. [Graphical view]
KO	K00965.
Pfam	PF02744. GalP_UDP_tr_C. 1 hit. PF01087. GalP_UDP_transf. 1 hit. [Graphical view]
PIRSF	PIRSF006005. GalT_BS. 1 hit.
TIGRFAMs	TIGR01239. GalT_2. 1 hit.
PROSITE	PS01163. GAL_P_UDP_TRANSF_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GALT_LACLA

Accession

Primary (citable) accession number: Q9CE63
Secondary accession number(s): O87522

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	June 1, 2001
Last modified:	January 25, 2012
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program