Q9CE42 (MSRA2_LACLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrA 2
Short name=Protein-methionine-S-oxide reductase 2
EC=1.8.4.11

Alternative name(s):
Peptide-methionine (S)-S-oxide reductase 2
Short name=Peptide Met(O) reductase 2

Gene names

Name:	msrA2
Synonyms:	pmsR
Ordered Locus Names:	LL2006
ORF Names:	L67708

Organism

Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)

Taxonomic identifier

272623 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus

Protein attributes

Sequence length	172 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01401
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401
Sequence similarities	Belongs to the MsrA Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 172	172	Peptide methionine sulfoxide reductase MsrA 2 HAMAP MF_01401		PRO_0000138552
Sites
	Active site	12	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9CE42 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: B84CCD0C5FE7F06F	FASTA	172	19,878
	10 20 30 40 50 60 MATERAIFAG GCFWCMVQPF EEREGILSVI SGYTGGNVEN PTYEQVKKHL TGHTEAVEII 70 80 90 100 110 120 FDNSKITYQS LVELYWTLTD PTDAFGQFED RGDNYRPVIF VENEEQEKIA KESKAQLQAS 130 140 150 160 170 GNFDSPIVTS IETVQKFWPA EDYHQGFYKK NPEDYAQSSK IRHDFLEKQW KK

References

[1]	"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403." Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A. Genome Res. 11:731-753(2001) [PubMed: 11337471] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IL1403.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005176 Genomic DNA. Translation: AAK06104.1.
PIR	F86875.
RefSeq	NP_268163.1. NC_002662.1.
3D structure databases
ProteinModelPortal	Q9CE42.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1115682.
GenomeReviews	Gene locus LL2006 in contig AE005176_GR.
KEGG	lla:L67708.
NMPDR	fig|272623.1.peg.2060.
PATRIC	22296536. VBILacLac136773_2161.
Phylogenomic databases
HOGENOM	HBG748152.
OMA	LVELYWT.
ProtClustDB	PRK14054.
Enzyme and pathway databases
BioCyc	LLAC272623:L67708-MONOMER.
Family and domain databases
HAMAP	MF_01401. MsrA. [Tree]
InterPro	IPR002569. Peptide_Met_Sox_Rdtase_MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
KO	K07304.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
SUPFAM	SSF55068. MsrA. 1 hit.
TIGRFAMs	TIGR00401. MsrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRA2_LACLA

Accession

Primary (citable) accession number: Q9CE42

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	June 1, 2001
Last modified:	January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program