Reviewed, UniProtKB/Swiss-Prot Q9CE36 (ACKA2_LACLA)

Names and origin

Protein names

Recommended name:
    Acetate kinase 2
    EC=2.7.2.1
Alternative name(s):
    Acetokinase 2

Gene names

Name:	ackA2
Ordered Locus Names:	LL2012
ORF Names:	L0224

Organism

Lactococcus lactis subsp. lactis (Streptococcus lactis) [Complete proteome] [HAMAP]

Taxonomic identifier

1360 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus

Protein attributes

Sequence length	395 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + acetate = ADP + acetyl phosphate. HAMAP MF_00020 ATP + propanoate = ADP + propanoyl phosphate. HAMAP MF_00020
Pathway	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. HAMAP MF_00020
Subcellular location	Cytoplasm By similarity HAMAP MF_00020.
Sequence similarities	Belongs to the acetokinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	organic acid metabolic process Inferred from electronic annotation. Source: InterPro phosphorylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 395	395	Acetate kinase 2 HAMAP MF_00020		PRO_0000107570

Sequences

	Sequence		Length	Mass (Da)
	Q9CE36-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: CEEB9B1D4B6E604E	FASTA	395	43,225
	10 20 30 40 50 60 MEKTLAVNAG SSSLKWQLYE MPEETVIAKG IFERIGLSGS ISTTKFNNEE HFRKQEIVDH 70 80 90 100 110 120 RQAVLLLMDE LIHFKLIHEF REITGIGHRV VAGGEFFKTS TVISPEVLAE IKNLSTLAPL 130 140 150 160 170 180 HNPANVLGIE AFQRLLPDAL AVAVFDTAFH STLPEKAYRY PIPTKYYEDY SIRKYGAHGT 190 200 210 220 230 240 SHMYVAQEAE KVLGKPLEDL KLITAHIGNG ASITAIEAGK SVDTSMGFTP LAGVMMGTRA 250 260 270 280 290 300 GEMDASVIPY MLESDPSLRN AQDVIDILNK DSGVLGVSEL SSDMRDLSEA VAKGNPKAIL 310 320 330 340 350 360 AYEMYVDRLK KFIAQYFGVL NGADALIFTA GVGENDTAVR TDVVNGLSWF GMEIDESKNV 370 380 390 RGAFGIISKP ESKVKVLVVP TNEELVIARD VEAAK

References

[1]

"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403." Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A. Genome Res. 11:731-753(2001) [PubMed: 11337471] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IL1403.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005176 Genomic DNA. Translation: AAK06110.1.
PIR	D86876.
RefSeq	NP_268169.1.
3D structure databases
SMR	Q9CE36. Positions 3-393.
ModBase	Search...
Genome annotation databases
GeneID	1115688.
GenomeReviews	Gene locus LL2012 in contig AE005176_GR.
KEGG	lla:L0224.
NMPDR	fig|272623.1.peg.2066.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG285863.
OMA	GNGASIN.
Enzyme and pathway databases
BioCyc	LLAC272623:L0224-MONOMER.
BRENDA	2.7.2.1. 278870.
Family and domain databases
HAMAP	MF_00020. Acetate_kinase. [Tree]
InterPro	IPR000890. Acetate/butyrate_kinase. IPR004372. AckA. [Graphical view]
PANTHER	PTHR21060. Acetate_kin. 1 hit. PTHR21060:SF11. AckA. 1 hit.
Pfam	PF00871. Acetate_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTS	PR00471. ACETATEKNASE.
TIGRFAMs	TIGR00016. ackA. 1 hit.
PROSITE	PS01075. ACETATE_KINASE_1. 1 hit. PS01076. ACETATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACKA2_LACLA

Accession

Primary (citable) accession number: Q9CE36

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2002
Last sequence update:	June 1, 2001
Last modified:	February 9, 2010
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)