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Q9CE12 (SYR_LACLA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:LL2038
ORF Names:L0344
OrganismLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis) [Reference proteome] [HAMAP]
Taxonomic identifier272623 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus

Protein attributes

Sequence length564 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 564564Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_0000151567

Regions

Motif122 – 13211"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
Q9CE12 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 9CA7B08A6F8D2CB7

FASTA56462,819
        10         20         30         40         50         60 
MDEKQLVSQA LSAAIDGVLG VEQIAAIIEK PKSSDLGDLA FPAFQLAKTL RKSPQIIAGE 

        70         80         90        100        110        120 
IAEKIDTKGF EKVIAVGPYV NFFLDKNATA SEVIREVLTE GEHYGDANIG QGGNVPIDMS 

       130        140        150        160        170        180 
APNIAKPFSI GHLRSTVIGD SIAKIYEKLG YQPIKINHLG DWGKQFGLLI TAYKKYGDEA 

       190        200        210        220        230        240 
TITANPIDEL LKLYVKINAE AKEDPEVDEE GRQWFLKMEQ GDEEALRIWK WFSDVSLIEF 

       250        260        270        280        290        300 
NRIYGKLGVS FDHFMGESFY SDKMDAIVED LESKNLLHES KGALIVDLEK YNLNPALIKK 

       310        320        330        340        350        360 
TDGATLYITR DLATAAYRKK TFNFVKSLYV VGGEQTNHFK QLKAVLKEAG YDWSDDMVHV 

       370        380        390        400        410        420 
PFGMVTQGGK KFSTRKGHVV KLEMALDEAV DRAEKQIEAK NPNLENKEEV AKQVGVGAVK 

       430        440        450        460        470        480 
FYDLKTDRNN GYDFDLDEMV SFEGETGPYV QYAHARIQSI LRKANRKVDI NNISLAVSDA 

       490        500        510        520        530        540 
EAWEIVKALK EFPNVVKRAA DNYEPSVIAK YAISLAQAFN KYYAHVRILE DDAQLDGRLA 

       550        560 
LISATSIVLK EALRLLGVAA PENM 

« Hide

References

[1]"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IL1403.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE005176 Genomic DNA. Translation: AAK06136.1.
PIRF86879.
RefSeqNP_268195.1. NC_002662.1.

3D structure databases

ProteinModelPortalQ9CE12.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272623.L0344.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK06136; AAK06136; L0344.
GeneID1115714.
KEGGlla:L0344.
PATRIC22296604. VBILacLac136773_2195.

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247211.
KOK01887.
OMAYVKFHDE.
OrthoDBEOG6JB13C.

Enzyme and pathway databases

BioCycLLAC272623:GHSH-2168-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYR_LACLA
AccessionPrimary (citable) accession number: Q9CE12
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: June 1, 2001
Last modified: May 14, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries