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Protein

DNA polymerase I

Gene

polA

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity.By similarity

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Exonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase
Biological processDNA damage, DNA repair, DNA replication

Enzyme and pathway databases

BioCyciLLAC272623:G1FZA-2256-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase I (EC:2.7.7.7)
Short name:
POL I
Gene namesi
Name:polA
Ordered Locus Names:LL2142
ORF Names:L0270
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
Proteomesi
  • UP000002196 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001012431 – 877DNA polymerase IAdd BLAST877

Proteomic databases

PaxDbiQ9CDS1
PRIDEiQ9CDS1

Interactioni

Subunit structurei

Single-chain monomer with multiple functions.

Protein-protein interaction databases

STRINGi272623.L0270

Structurei

3D structure databases

ProteinModelPortaliQ9CDS1
SMRiQ9CDS1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini180 – 2705'-3' exonucleaseSequence analysisAdd BLAST91
Domaini308 – 4683'-5' exonucleaseSequence analysisAdd BLAST161

Sequence similaritiesi

Belongs to the DNA polymerase type-A family.Curated

Phylogenomic databases

eggNOGiENOG4105C2M Bacteria
COG0258 LUCA
COG0749 LUCA
HOGENOMiHOG000020998
KOiK02335
OMAiETGRVHT

Family and domain databases

CDDicd09898 H3TH_53EXO, 1 hit
Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR002562 3'-5'_exonuclease_dom
IPR020046 5-3_exonucl_a-hlix_arch_N
IPR036279 5-3_exonuclease_C_sf
IPR002421 5-3_exonuclease_N
IPR019760 DNA-dir_DNA_pol_A_CS
IPR001098 DNA-dir_DNA_pol_A_palm_dom
IPR020045 DNA_polI_H3TH
IPR018320 DNA_polymerase_1
IPR002298 DNA_polymerase_A
IPR008918 HhH2
IPR029060 PIN-like_dom_sf
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PANTHERiPTHR10133 PTHR10133, 1 hit
PfamiView protein in Pfam
PF01367 5_3_exonuc, 1 hit
PF02739 5_3_exonuc_N, 1 hit
PF00476 DNA_pol_A, 1 hit
PRINTSiPR00868 DNAPOLI
SMARTiView protein in SMART
SM00474 35EXOc, 1 hit
SM00475 53EXOc, 1 hit
SM00279 HhH2, 1 hit
SM00482 POLAc, 1 hit
SUPFAMiSSF47807 SSF47807, 1 hit
SSF53098 SSF53098, 1 hit
SSF88723 SSF88723, 1 hit
TIGRFAMsiTIGR00593 pola, 1 hit
PROSITEiView protein in PROSITE
PS00447 DNA_POLYMERASE_A, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CDS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENKDRLLLI DGSSVAFRAF FALYNQIDRF KAPNGLHTNA IFAFHTMLSS
60 70 80 90 100
LMERIEPTHV LIAFDAGKTT FRTEMFADYK GGRSKTPDEF REQLPFIKEM
110 120 130 140 150
IEKLGIRHYE LANYEADDII GTLDKMAEAP NVNFDVTIVT GDKDMIQLVD
160 170 180 190 200
GNTRVEISKK GVAEFEEFTP DYLLEKMGLT PAQFIDLKAL MGDSSDNYPG
210 220 230 240 250
VTKVGEKTGL KLLQEFGSLE NLYENVDSLK ASKMKENLIA DKEMAFLSQQ
260 270 280 290 300
LATINTKAPI EIGLDDTLLK GKKVDELSQF YDEMGFAQFK SKLLAEAGGE
310 320 330 340 350
VTDEKVVDEI DFEIVTDGSI SEKVNADDFF YLETLGENYH REQIVAFAWG
360 370 380 390 400
NAEKIYVSKN IDLLTKMKFP ENTYDFKKNR VLLSHLDIEL PLVKFDAMLA
410 420 430 440 450
KYLISTTEDN KISTIARLFN SGHLATDEEI FGKGTKIALP DDAVLFEHLA
460 470 480 490 500
RKIKVLALAK EKMMAELLEN EQEHLLSDME LPLAEVLAKM EITGIAVSQN
510 520 530 540 550
TLEEIGAENE EKLASLTREI YDLAGEEFNI NSPKQLGVIL FEKLQLPVGK
560 570 580 590 600
KTKTGYSTAV DVLEDLAALS PVVAKILEYR QINKVQSTYV KGLIPQIADD
610 620 630 640 650
GKIHTRYVQD LTQTGRLSSV DPNLQNIPVR LEEGRKIRKA FVPSKDSLLL
660 670 680 690 700
SSDYSQIELR VLAHISGDEH LIDAFKHGAD IHTSTAMRVF GIEKAEDVTA
710 720 730 740 750
NDRRNAKAVN FGVVYGISDF GLARNLGITR KDAKNYIETY FERYPGIKTY
760 770 780 790 800
MENIVREARD KGFVETMSHR RRKIPDINAR NFNVRGFAER TAINSPIQGS
810 820 830 840 850
AADILKIAMI NLDKALSARD FKSKLLLQVH DEIILDVPLE ELDEIKVLVK
860 870
QTMEEAIELA VPLKVDENTG KTWYEAK
Length:877
Mass (Da):98,733
Last modified:June 1, 2001 - v1
Checksum:iA5C2BEB92FF98FB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005176 Genomic DNA Translation: AAK06240.1
PIRiF86892
RefSeqiNP_268299.1, NC_002662.1
WP_010906334.1, NC_002662.1

Genome annotation databases

EnsemblBacteriaiAAK06240; AAK06240; L0270
GeneIDi1115819
KEGGilla:L0270
PATRICifig|272623.7.peg.2301

Similar proteinsi

Entry informationi

Entry nameiDPO1_LACLA
AccessioniPrimary (citable) accession number: Q9CDS1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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