Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA polymerase I

Gene

polA

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' and 5' to 3' exonuclease activity.By similarity

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Exonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA damage, DNA repair, DNA replication

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciLLAC272623:GHSH-2274-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase I (EC:2.7.7.7)
Short name:
POL I
Gene namesi
Name:polA
Ordered Locus Names:LL2142
ORF Names:L0270
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
Proteomesi
  • UP000002196 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 877877DNA polymerase IPRO_0000101243Add
BLAST

Proteomic databases

PaxDbiQ9CDS1.
PRIDEiQ9CDS1.

Interactioni

Subunit structurei

Single-chain monomer with multiple functions.

Protein-protein interaction databases

STRINGi272623.L0270.

Structurei

3D structure databases

ProteinModelPortaliQ9CDS1.
SMRiQ9CDS1. Positions 309-877.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA polymerase type-A family.Curated
Contains 1 3'-5' exonuclease domain.Curated
Contains 1 5'-3' exonuclease domain.Curated

Phylogenomic databases

eggNOGiENOG4105C2M. Bacteria.
COG0258. LUCA.
COG0749. LUCA.
HOGENOMiHOG000020998.
KOiK02335.
OMAiCFDTETT.
OrthoDBiEOG6SJJH7.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.40.50.1010. 1 hit.
InterProiIPR002562. 3'-5'_exonuclease_dom.
IPR020046. 5-3_exonucl_a-hlix_arch_N.
IPR020045. 5-3_exonuclease_C.
IPR002421. 5-3_exonuclease_N.
IPR019760. DNA-dir_DNA_pol_A_CS.
IPR001098. DNA-dir_DNA_pol_A_palm_dom.
IPR018320. DNA_polymerase_1.
IPR002298. DNA_polymerase_A.
IPR008918. HhH2.
IPR029060. PIN_domain-like.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF01367. 5_3_exonuc. 1 hit.
PF02739. 5_3_exonuc_N. 1 hit.
PF00476. DNA_pol_A. 1 hit.
[Graphical view]
PRINTSiPR00868. DNAPOLI.
SMARTiSM00474. 35EXOc. 1 hit.
SM00475. 53EXOc. 1 hit.
SM00279. HhH2. 1 hit.
SM00482. POLAc. 1 hit.
[Graphical view]
SUPFAMiSSF47807. SSF47807. 1 hit.
SSF53098. SSF53098. 1 hit.
SSF88723. SSF88723. 1 hit.
TIGRFAMsiTIGR00593. pola. 1 hit.
PROSITEiPS00447. DNA_POLYMERASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CDS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENKDRLLLI DGSSVAFRAF FALYNQIDRF KAPNGLHTNA IFAFHTMLSS
60 70 80 90 100
LMERIEPTHV LIAFDAGKTT FRTEMFADYK GGRSKTPDEF REQLPFIKEM
110 120 130 140 150
IEKLGIRHYE LANYEADDII GTLDKMAEAP NVNFDVTIVT GDKDMIQLVD
160 170 180 190 200
GNTRVEISKK GVAEFEEFTP DYLLEKMGLT PAQFIDLKAL MGDSSDNYPG
210 220 230 240 250
VTKVGEKTGL KLLQEFGSLE NLYENVDSLK ASKMKENLIA DKEMAFLSQQ
260 270 280 290 300
LATINTKAPI EIGLDDTLLK GKKVDELSQF YDEMGFAQFK SKLLAEAGGE
310 320 330 340 350
VTDEKVVDEI DFEIVTDGSI SEKVNADDFF YLETLGENYH REQIVAFAWG
360 370 380 390 400
NAEKIYVSKN IDLLTKMKFP ENTYDFKKNR VLLSHLDIEL PLVKFDAMLA
410 420 430 440 450
KYLISTTEDN KISTIARLFN SGHLATDEEI FGKGTKIALP DDAVLFEHLA
460 470 480 490 500
RKIKVLALAK EKMMAELLEN EQEHLLSDME LPLAEVLAKM EITGIAVSQN
510 520 530 540 550
TLEEIGAENE EKLASLTREI YDLAGEEFNI NSPKQLGVIL FEKLQLPVGK
560 570 580 590 600
KTKTGYSTAV DVLEDLAALS PVVAKILEYR QINKVQSTYV KGLIPQIADD
610 620 630 640 650
GKIHTRYVQD LTQTGRLSSV DPNLQNIPVR LEEGRKIRKA FVPSKDSLLL
660 670 680 690 700
SSDYSQIELR VLAHISGDEH LIDAFKHGAD IHTSTAMRVF GIEKAEDVTA
710 720 730 740 750
NDRRNAKAVN FGVVYGISDF GLARNLGITR KDAKNYIETY FERYPGIKTY
760 770 780 790 800
MENIVREARD KGFVETMSHR RRKIPDINAR NFNVRGFAER TAINSPIQGS
810 820 830 840 850
AADILKIAMI NLDKALSARD FKSKLLLQVH DEIILDVPLE ELDEIKVLVK
860 870
QTMEEAIELA VPLKVDENTG KTWYEAK
Length:877
Mass (Da):98,733
Last modified:June 1, 2001 - v1
Checksum:iA5C2BEB92FF98FB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005176 Genomic DNA. Translation: AAK06240.1.
PIRiF86892.
RefSeqiNP_268299.1. NC_002662.1.
WP_010906334.1. NC_002662.1.

Genome annotation databases

EnsemblBacteriaiAAK06240; AAK06240; L0270.
GeneIDi1115819.
KEGGilla:L0270.
PATRICi22296818. VBILacLac136773_2301.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005176 Genomic DNA. Translation: AAK06240.1.
PIRiF86892.
RefSeqiNP_268299.1. NC_002662.1.
WP_010906334.1. NC_002662.1.

3D structure databases

ProteinModelPortaliQ9CDS1.
SMRiQ9CDS1. Positions 309-877.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272623.L0270.

Proteomic databases

PaxDbiQ9CDS1.
PRIDEiQ9CDS1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK06240; AAK06240; L0270.
GeneIDi1115819.
KEGGilla:L0270.
PATRICi22296818. VBILacLac136773_2301.

Phylogenomic databases

eggNOGiENOG4105C2M. Bacteria.
COG0258. LUCA.
COG0749. LUCA.
HOGENOMiHOG000020998.
KOiK02335.
OMAiCFDTETT.
OrthoDBiEOG6SJJH7.

Enzyme and pathway databases

BioCyciLLAC272623:GHSH-2274-MONOMER.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.40.50.1010. 1 hit.
InterProiIPR002562. 3'-5'_exonuclease_dom.
IPR020046. 5-3_exonucl_a-hlix_arch_N.
IPR020045. 5-3_exonuclease_C.
IPR002421. 5-3_exonuclease_N.
IPR019760. DNA-dir_DNA_pol_A_CS.
IPR001098. DNA-dir_DNA_pol_A_palm_dom.
IPR018320. DNA_polymerase_1.
IPR002298. DNA_polymerase_A.
IPR008918. HhH2.
IPR029060. PIN_domain-like.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF01367. 5_3_exonuc. 1 hit.
PF02739. 5_3_exonuc_N. 1 hit.
PF00476. DNA_pol_A. 1 hit.
[Graphical view]
PRINTSiPR00868. DNAPOLI.
SMARTiSM00474. 35EXOc. 1 hit.
SM00475. 53EXOc. 1 hit.
SM00279. HhH2. 1 hit.
SM00482. POLAc. 1 hit.
[Graphical view]
SUPFAMiSSF47807. SSF47807. 1 hit.
SSF53098. SSF53098. 1 hit.
SSF88723. SSF88723. 1 hit.
TIGRFAMsiTIGR00593. pola. 1 hit.
PROSITEiPS00447. DNA_POLYMERASE_A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
    Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
    Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IL1403.

Entry informationi

Entry nameiDPO1_LACLA
AccessioniPrimary (citable) accession number: Q9CDS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: November 11, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.