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Q9CDM7 (UPPP_LACLA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:LL2192
ORF Names:L58643
OrganismLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis) [Reference proteome] [HAMAP]
Taxonomic identifier272623 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus

Protein attributes

Sequence length284 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 284284Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151158

Regions

Transmembrane7 – 2721Helical; Potential
Transmembrane44 – 6421Helical; Potential
Transmembrane90 – 11021Helical; Potential
Transmembrane116 – 13621Helical; Potential
Transmembrane167 – 18721Helical; Potential
Transmembrane197 – 21721Helical; Potential
Transmembrane229 – 24921Helical; Potential
Transmembrane259 – 27921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q9CDM7 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 83ABD014DDDBB14E

FASTA28432,079
        10         20         30         40         50         60 
MDFIRAIILG VIEGITEWLP ISSTGHLIIA DEFIRLNQSA AFKEMFDVVI QLGAILSVVV 

        70         80         90        100        110        120 
LYFHKLNPFN KLNPADKQKT PREIQLTWRL WLKVLIAALP AAIIGLPLND WLDKHFYHFV 

       130        140        150        160        170        180 
PVAFMLIIYG VAFIVIERRW VPNHEFSVMN IDRLPYRAAL YIGLFQVLSL LPGTSRSGAT 

       190        200        210        220        230        240 
IVGALLVGVS REVAAEFTFF LGIPVMFGAS FIKILHFFKN GNSLSFEQFG VLLVACIVAF 

       250        260        270        280 
GVSMVAIKFL TDYVKKHDFT FFGKYRIVLG IILLIYAMFR AFLG 

« Hide

References

[1]"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IL1403.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE005176 Genomic DNA. Translation: AAK06290.1.
PIRH86898.
RefSeqNP_268349.1. NC_002662.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272623.L58643.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK06290; AAK06290; L58643.
GeneID1115870.
KEGGlla:L58643.
PATRIC22296940. VBILacLac136773_2354.

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAAQCFALI.
OrthoDBEOG6QP13M.
ProtClustDBPRK00281.

Enzyme and pathway databases

BioCycLLAC272623:GHSH-2333-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_LACLA
AccessionPrimary (citable) accession number: Q9CDM7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: June 1, 2001
Last modified: February 19, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families