Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA polymerase III subunit gamma/tau

Gene

dnaH

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.UniRule annotation

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-directed DNA polymeraseUniRule annotation, Nucleotidyltransferase, Transferase
Biological processDNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase III subunit gamma/tauUniRule annotation (EC:2.7.7.7UniRule annotation)
Gene namesi
Name:dnaHImported
Synonyms:dnaXUniRule annotation
ORF Names:L0279Imported
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)Imported
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
Proteomesi
  • UP000002196 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Proteomic databases

PaxDbiQ9CDM5.

Interactioni

Subunit structurei

DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.UniRule annotation

Protein-protein interaction databases

STRINGi272623.L0279.

Structurei

3D structure databases

ProteinModelPortaliQ9CDM5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 184AAAInterPro annotationAdd BLAST148

Sequence similaritiesi

Belongs to the DnaX/STICHEL family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C6E. Bacteria.
COG2812. LUCA.
HOGENOMiHOG000083933.
KOiK02343.
OMAiRTQRYNF.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR001270. ClpA/B.
IPR008921. DNA_pol3_clamp-load_cplx_C.
IPR012763. DNA_pol_III_sug/sutau.
IPR027417. P-loop_NTPase.
PRINTSiPR00300. CLPPROTEASEA.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF48019. SSF48019. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02397. dnaX_nterm. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CDM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYQALYRKY RSQRFDEMVG QEVVATTLKN AIVNHQISHA YLFSGPRGTG
60 70 80 90 100
KTSAAKIFAK AINCPNQVDG EPCNNCFICD SITKGSLDDV IELDAASNNG
110 120 130 140 150
VDEIREIRDK STYAASQATY KVYIIDEVHM LSTGAFNALL KTLEEPTENV
160 170 180 190 200
VFVLATTELQ KIPATIISRV QRFAFKSITT GDIRTYLAKI MADEGLEFDG
210 220 230 240 250
KALDVIAKAA EGGMRDALSL LDQALSFSSG KLEENDALLV TGSIAADALV
260 270 280 290 300
TYVAALFEHD EAKAMTELDK IFAEGKNMLR FTEDLLAYLR DLLLDKNSQY
310 320 330 340 350
DRGQIFSWID VAIESLKTIK ETTQTKIAAD VMTMRLAEIG QNNLLTASQG
360 370 380 390 400
EIPNQLTAEI ATLKTEINQL KAQISAGQIQ VNSDSQNNLL TENVKASPKP
410 420 430 440 450
IASKKRQINK DLIYKALAEA TNEARKAALS AWPELVASVT KPADRALLNN
460 470 480 490 500
TAPVAASENF LVVTFPHENL AKRVSENEEL QLFCGNLLSS IVGFAPEIIS
510 520 530 540 550
LAEQDWQEVR AEYVSNLKSE NVQEDEEDEK EPDETVNLAK ELFGEKVVEI

ND
Length:552
Mass (Da):60,766
Last modified:June 1, 2001 - v1
Checksum:iCC0438E81C6C2D3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005176 Genomic DNA. Translation: AAK06292.1.
PIRiB86899.
RefSeqiNP_268351.1. NC_002662.1.
WP_010906374.1. NC_002662.1.

Genome annotation databases

EnsemblBacteriaiAAK06292; AAK06292; L0279.
GeneIDi1115872.
KEGGilla:L0279.
PATRICifig|272623.7.peg.2356.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ9CDM5_LACLA
AccessioniPrimary (citable) accession number: Q9CDM5
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: June 7, 2017
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported