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Protein

DNA mismatch repair protein MutS

Gene

mutS

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi601 – 6088ATPSequence Analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLLAC272623:GHSH-2351-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair protein MutS
Gene namesi
Name:mutS
Synonyms:hexA
Ordered Locus Names:LL2210
ORF Names:L0277
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
ProteomesiUP000002196 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 840840DNA mismatch repair protein MutSPRO_0000115104Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272623.L0277.

Structurei

3D structure databases

ProteinModelPortaliQ9CDK9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA mismatch repair MutS family.Curated

Phylogenomic databases

eggNOGiCOG0249.
HOGENOMiHOG000221406.
KOiK03555.
OMAiCLLLFRM.
OrthoDBiEOG6Q5NPV.

Family and domain databases

Gene3Di3.30.420.110. 1 hit.
3.40.1170.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00096. MutS.
InterProiIPR005748. DNA_mismatch_repair_MutS-1.
IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53150. SSF53150. 1 hit.
SSF55271. SSF55271. 1 hit.
TIGRFAMsiTIGR01070. mutS1. 1 hit.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CDK9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKISPGMQ QYLDIKQDYP DAFLLFRMGD FYELFYDDAV NAAQILELTL
60 70 80 90 100
TSRNKNSENP IPMAGVPHHA AAEYIDKLVD LGYKVAVAEQ MEDPKKAVGI
110 120 130 140 150
VKRAVTQVIT PGTTIDTANS VDNNFLVAID FKDKHYALSY MDLSTGEFKV
160 170 180 190 200
TELSEFSAVV GEIASLKARE IVAGFTLDES QLKVFERQMN LLISEQLEIP
210 220 230 240 250
ENLLIDLSGL TALENQVASK LLAYVKETQM RDLSHLQEVE HYEIKDFLQM
260 270 280 290 300
DFATKSSLEL TANKRENKKH GTLYWLLDET KTAMGTRMLR SWIDRPLISN
310 320 330 340 350
SAIQKRMEIV QIFLDHFFER SDLIEALKGV YDLERLASRV SFGKAVPVDF
360 370 380 390 400
LQLANSLSNV PAIKYILGML NEAPLEELKS QLDEIPELSG LINSAISENA
410 420 430 440 450
SRTITEGGII KKGYNAQLDK YREALENGTS WIAKLEADEK AKTGISTLRI
460 470 480 490 500
DYNRKDGYYF HITQSQLNSV PEHFYRKATL KNSERFGSQE LTEIEEIMLE
510 520 530 540 550
AREKSSSLEY DLFMGLRTET EQYIGRLQAL AKTIAEIDCL QSLSVVAEKQ
560 570 580 590 600
GYIRPTLTDG SRIVEIKGGR HAVVEAVMGA QEYVPNDIEL PEQTDIQLIT
610 620 630 640 650
GPNMSGKSTY MRQFALTVIM AQIGSFVPAE TANLPIFDAI FTRIGASDNL
660 670 680 690 700
ISGESTFMVE MSEANHAIQK ASSRSLIIFD ELGRGTATYD GMALAQAIIE
710 720 730 740 750
YVHDHIGAKT LFATHYHELT DLDEALDHLD NVHVATLEQN GNVTFLHKIT
760 770 780 790 800
EGPADKSYGI HVAKIAGLPQ PLLERADLIL QKLENKPLPA KKVADEQEQL
810 820 830 840
SLFDFTENSS EIIEKIKRQN VDNMTAREAL NFLWELKDSL
Length:840
Mass (Da):94,272
Last modified:April 27, 2001 - v1
Checksum:i867EFE4F82616DC2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005176 Genomic DNA. Translation: AAK06308.1.
PIRiB86901.
RefSeqiNP_268367.1. NC_002662.1.
WP_010906385.1. NC_002662.1.

Genome annotation databases

EnsemblBacteriaiAAK06308; AAK06308; L0277.
GeneIDi1115888.
KEGGilla:L0277.
PATRICi22296980. VBILacLac136773_2374.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005176 Genomic DNA. Translation: AAK06308.1.
PIRiB86901.
RefSeqiNP_268367.1. NC_002662.1.
WP_010906385.1. NC_002662.1.

3D structure databases

ProteinModelPortaliQ9CDK9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272623.L0277.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK06308; AAK06308; L0277.
GeneIDi1115888.
KEGGilla:L0277.
PATRICi22296980. VBILacLac136773_2374.

Phylogenomic databases

eggNOGiCOG0249.
HOGENOMiHOG000221406.
KOiK03555.
OMAiCLLLFRM.
OrthoDBiEOG6Q5NPV.

Enzyme and pathway databases

BioCyciLLAC272623:GHSH-2351-MONOMER.

Family and domain databases

Gene3Di3.30.420.110. 1 hit.
3.40.1170.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00096. MutS.
InterProiIPR005748. DNA_mismatch_repair_MutS-1.
IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53150. SSF53150. 1 hit.
SSF55271. SSF55271. 1 hit.
TIGRFAMsiTIGR01070. mutS1. 1 hit.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
    Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
    Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IL1403.

Entry informationi

Entry nameiMUTS_LACLA
AccessioniPrimary (citable) accession number: Q9CDK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: May 27, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.