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Q9CDK9

- MUTS_LACLA

UniProt

Q9CDK9 - MUTS_LACLA

Protein

DNA mismatch repair protein MutS

Gene

mutS

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (27 Apr 2001)
      Previous versions | rss
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    Functioni

    This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi601 – 6088ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. damaged DNA binding Source: UniProtKB-HAMAP
    3. mismatched DNA binding Source: InterPro

    GO - Biological processi

    1. mismatch repair Source: UniProtKB-HAMAP

    Keywords - Biological processi

    DNA damage, DNA repair

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLLAC272623:GHSH-2351-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA mismatch repair protein MutS
    Gene namesi
    Name:mutS
    Synonyms:hexA
    Ordered Locus Names:LL2210
    ORF Names:L0277
    OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
    Taxonomic identifieri272623 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
    ProteomesiUP000002196: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 840840DNA mismatch repair protein MutSPRO_0000115104Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272623.L0277.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CDK9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DNA mismatch repair MutS family.Curated

    Phylogenomic databases

    eggNOGiCOG0249.
    HOGENOMiHOG000221406.
    KOiK03555.
    OMAiTEDIVNH.
    OrthoDBiEOG6Q5NPV.

    Family and domain databases

    Gene3Di3.30.420.110. 1 hit.
    3.40.1170.10. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_00096. MutS.
    InterProiIPR005748. DNA_mismatch_repair_MutS-1.
    IPR007695. DNA_mismatch_repair_MutS-lik_N.
    IPR000432. DNA_mismatch_repair_MutS_C.
    IPR007861. DNA_mismatch_repair_MutS_clamp.
    IPR007696. DNA_mismatch_repair_MutS_core.
    IPR016151. DNA_mismatch_repair_MutS_N.
    IPR007860. DNA_mmatch_repair_MutS_con_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01624. MutS_I. 1 hit.
    PF05188. MutS_II. 1 hit.
    PF05192. MutS_III. 1 hit.
    PF05190. MutS_IV. 1 hit.
    PF00488. MutS_V. 1 hit.
    [Graphical view]
    SMARTiSM00534. MUTSac. 1 hit.
    SM00533. MUTSd. 1 hit.
    [Graphical view]
    SUPFAMiSSF48334. SSF48334. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF53150. SSF53150. 1 hit.
    SSF55271. SSF55271. 1 hit.
    TIGRFAMsiTIGR01070. mutS1. 1 hit.
    PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9CDK9-1 [UniParc]FASTAAdd to Basket

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    MAEKISPGMQ QYLDIKQDYP DAFLLFRMGD FYELFYDDAV NAAQILELTL    50
    TSRNKNSENP IPMAGVPHHA AAEYIDKLVD LGYKVAVAEQ MEDPKKAVGI 100
    VKRAVTQVIT PGTTIDTANS VDNNFLVAID FKDKHYALSY MDLSTGEFKV 150
    TELSEFSAVV GEIASLKARE IVAGFTLDES QLKVFERQMN LLISEQLEIP 200
    ENLLIDLSGL TALENQVASK LLAYVKETQM RDLSHLQEVE HYEIKDFLQM 250
    DFATKSSLEL TANKRENKKH GTLYWLLDET KTAMGTRMLR SWIDRPLISN 300
    SAIQKRMEIV QIFLDHFFER SDLIEALKGV YDLERLASRV SFGKAVPVDF 350
    LQLANSLSNV PAIKYILGML NEAPLEELKS QLDEIPELSG LINSAISENA 400
    SRTITEGGII KKGYNAQLDK YREALENGTS WIAKLEADEK AKTGISTLRI 450
    DYNRKDGYYF HITQSQLNSV PEHFYRKATL KNSERFGSQE LTEIEEIMLE 500
    AREKSSSLEY DLFMGLRTET EQYIGRLQAL AKTIAEIDCL QSLSVVAEKQ 550
    GYIRPTLTDG SRIVEIKGGR HAVVEAVMGA QEYVPNDIEL PEQTDIQLIT 600
    GPNMSGKSTY MRQFALTVIM AQIGSFVPAE TANLPIFDAI FTRIGASDNL 650
    ISGESTFMVE MSEANHAIQK ASSRSLIIFD ELGRGTATYD GMALAQAIIE 700
    YVHDHIGAKT LFATHYHELT DLDEALDHLD NVHVATLEQN GNVTFLHKIT 750
    EGPADKSYGI HVAKIAGLPQ PLLERADLIL QKLENKPLPA KKVADEQEQL 800
    SLFDFTENSS EIIEKIKRQN VDNMTAREAL NFLWELKDSL 840
    Length:840
    Mass (Da):94,272
    Last modified:April 27, 2001 - v1
    Checksum:i867EFE4F82616DC2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005176 Genomic DNA. Translation: AAK06308.1.
    PIRiB86901.
    RefSeqiNP_268367.1. NC_002662.1.

    Genome annotation databases

    EnsemblBacteriaiAAK06308; AAK06308; L0277.
    GeneIDi1115888.
    KEGGilla:L0277.
    PATRICi22296980. VBILacLac136773_2374.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005176 Genomic DNA. Translation: AAK06308.1 .
    PIRi B86901.
    RefSeqi NP_268367.1. NC_002662.1.

    3D structure databases

    ProteinModelPortali Q9CDK9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272623.L0277.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK06308 ; AAK06308 ; L0277 .
    GeneIDi 1115888.
    KEGGi lla:L0277.
    PATRICi 22296980. VBILacLac136773_2374.

    Phylogenomic databases

    eggNOGi COG0249.
    HOGENOMi HOG000221406.
    KOi K03555.
    OMAi TEDIVNH.
    OrthoDBi EOG6Q5NPV.

    Enzyme and pathway databases

    BioCyci LLAC272623:GHSH-2351-MONOMER.

    Family and domain databases

    Gene3Di 3.30.420.110. 1 hit.
    3.40.1170.10. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_00096. MutS.
    InterProi IPR005748. DNA_mismatch_repair_MutS-1.
    IPR007695. DNA_mismatch_repair_MutS-lik_N.
    IPR000432. DNA_mismatch_repair_MutS_C.
    IPR007861. DNA_mismatch_repair_MutS_clamp.
    IPR007696. DNA_mismatch_repair_MutS_core.
    IPR016151. DNA_mismatch_repair_MutS_N.
    IPR007860. DNA_mmatch_repair_MutS_con_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01624. MutS_I. 1 hit.
    PF05188. MutS_II. 1 hit.
    PF05192. MutS_III. 1 hit.
    PF05190. MutS_IV. 1 hit.
    PF00488. MutS_V. 1 hit.
    [Graphical view ]
    SMARTi SM00534. MUTSac. 1 hit.
    SM00533. MUTSd. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48334. SSF48334. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF53150. SSF53150. 1 hit.
    SSF55271. SSF55271. 1 hit.
    TIGRFAMsi TIGR01070. mutS1. 1 hit.
    PROSITEi PS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
      Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
      Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: IL1403.

    Entry informationi

    Entry nameiMUTS_LACLA
    AccessioniPrimary (citable) accession number: Q9CDK9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: April 27, 2001
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3