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Protein

DNA mismatch repair protein MutS

Gene

mutS

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi601 – 608ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA damage, DNA repair
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLLAC272623:G1FZA-2333-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair protein MutS
Gene namesi
Name:mutS
Synonyms:hexA
Ordered Locus Names:LL2210
ORF Names:L0277
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
Proteomesi
  • UP000002196 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001151041 – 840DNA mismatch repair protein MutSAdd BLAST840

Proteomic databases

PaxDbiQ9CDK9
PRIDEiQ9CDK9

Interactioni

Protein-protein interaction databases

STRINGi272623.L0277

Structurei

3D structure databases

ProteinModelPortaliQ9CDK9
SMRiQ9CDK9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA mismatch repair MutS family.Curated

Phylogenomic databases

eggNOGiENOG4105D86 Bacteria
COG0249 LUCA
HOGENOMiHOG000221406
KOiK03555
OMAiTPMMAQY

Family and domain databases

Gene3Di3.30.420.110, 1 hit
3.40.1170.10, 1 hit
HAMAPiMF_00096 MutS, 1 hit
InterProiView protein in InterPro
IPR005748 DNA_mismatch_repair_MutS
IPR007695 DNA_mismatch_repair_MutS-lik_N
IPR017261 DNA_mismatch_repair_MutS/MSH
IPR000432 DNA_mismatch_repair_MutS_C
IPR007861 DNA_mismatch_repair_MutS_clamp
IPR007696 DNA_mismatch_repair_MutS_core
IPR016151 DNA_mismatch_repair_MutS_N
IPR036187 DNA_mismatch_repair_MutS_sf
IPR007860 DNA_mmatch_repair_MutS_con_dom
IPR036678 MutS_con_dom_sf
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01624 MutS_I, 1 hit
PF05188 MutS_II, 1 hit
PF05192 MutS_III, 1 hit
PF05190 MutS_IV, 1 hit
PF00488 MutS_V, 1 hit
PIRSFiPIRSF037677 DNA_mis_repair_Msh6, 1 hit
SMARTiView protein in SMART
SM00534 MUTSac, 1 hit
SM00533 MUTSd, 1 hit
SUPFAMiSSF48334 SSF48334, 1 hit
SSF52540 SSF52540, 1 hit
SSF53150 SSF53150, 1 hit
SSF55271 SSF55271, 1 hit
TIGRFAMsiTIGR01070 mutS1, 1 hit
PROSITEiView protein in PROSITE
PS00486 DNA_MISMATCH_REPAIR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CDK9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKISPGMQ QYLDIKQDYP DAFLLFRMGD FYELFYDDAV NAAQILELTL
60 70 80 90 100
TSRNKNSENP IPMAGVPHHA AAEYIDKLVD LGYKVAVAEQ MEDPKKAVGI
110 120 130 140 150
VKRAVTQVIT PGTTIDTANS VDNNFLVAID FKDKHYALSY MDLSTGEFKV
160 170 180 190 200
TELSEFSAVV GEIASLKARE IVAGFTLDES QLKVFERQMN LLISEQLEIP
210 220 230 240 250
ENLLIDLSGL TALENQVASK LLAYVKETQM RDLSHLQEVE HYEIKDFLQM
260 270 280 290 300
DFATKSSLEL TANKRENKKH GTLYWLLDET KTAMGTRMLR SWIDRPLISN
310 320 330 340 350
SAIQKRMEIV QIFLDHFFER SDLIEALKGV YDLERLASRV SFGKAVPVDF
360 370 380 390 400
LQLANSLSNV PAIKYILGML NEAPLEELKS QLDEIPELSG LINSAISENA
410 420 430 440 450
SRTITEGGII KKGYNAQLDK YREALENGTS WIAKLEADEK AKTGISTLRI
460 470 480 490 500
DYNRKDGYYF HITQSQLNSV PEHFYRKATL KNSERFGSQE LTEIEEIMLE
510 520 530 540 550
AREKSSSLEY DLFMGLRTET EQYIGRLQAL AKTIAEIDCL QSLSVVAEKQ
560 570 580 590 600
GYIRPTLTDG SRIVEIKGGR HAVVEAVMGA QEYVPNDIEL PEQTDIQLIT
610 620 630 640 650
GPNMSGKSTY MRQFALTVIM AQIGSFVPAE TANLPIFDAI FTRIGASDNL
660 670 680 690 700
ISGESTFMVE MSEANHAIQK ASSRSLIIFD ELGRGTATYD GMALAQAIIE
710 720 730 740 750
YVHDHIGAKT LFATHYHELT DLDEALDHLD NVHVATLEQN GNVTFLHKIT
760 770 780 790 800
EGPADKSYGI HVAKIAGLPQ PLLERADLIL QKLENKPLPA KKVADEQEQL
810 820 830 840
SLFDFTENSS EIIEKIKRQN VDNMTAREAL NFLWELKDSL
Length:840
Mass (Da):94,272
Last modified:April 27, 2001 - v1
Checksum:i867EFE4F82616DC2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005176 Genomic DNA Translation: AAK06308.1
PIRiB86901
RefSeqiNP_268367.1, NC_002662.1
WP_010906385.1, NC_002662.1

Genome annotation databases

EnsemblBacteriaiAAK06308; AAK06308; L0277
GeneIDi1115888
KEGGilla:L0277
PATRICifig|272623.7.peg.2374

Similar proteinsi

Entry informationi

Entry nameiMUTS_LACLA
AccessioniPrimary (citable) accession number: Q9CDK9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: May 23, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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