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Q9CDK9 (MUTS_LACLA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA mismatch repair protein MutS
Gene names
Name:mutS
Synonyms:hexA
Ordered Locus Names:LL2210
ORF Names:L0277
OrganismLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis) [Reference proteome] [HAMAP]
Taxonomic identifier272623 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus

Protein attributes

Sequence length840 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity By similarity. HAMAP-Rule MF_00096

Sequence similarities

Belongs to the DNA mismatch repair MutS family.

Ontologies

Keywords
   Biological processDNA damage
DNA repair
   LigandATP-binding
DNA-binding
Nucleotide-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmismatch repair

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

damaged DNA binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

mismatched DNA binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 840840DNA mismatch repair protein MutS HAMAP-Rule MF_00096
PRO_0000115104

Regions

Nucleotide binding601 – 6088ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q9CDK9 [UniParc].

Last modified April 27, 2001. Version 1.
Checksum: 867EFE4F82616DC2

FASTA84094,272
        10         20         30         40         50         60 
MAEKISPGMQ QYLDIKQDYP DAFLLFRMGD FYELFYDDAV NAAQILELTL TSRNKNSENP 

        70         80         90        100        110        120 
IPMAGVPHHA AAEYIDKLVD LGYKVAVAEQ MEDPKKAVGI VKRAVTQVIT PGTTIDTANS 

       130        140        150        160        170        180 
VDNNFLVAID FKDKHYALSY MDLSTGEFKV TELSEFSAVV GEIASLKARE IVAGFTLDES 

       190        200        210        220        230        240 
QLKVFERQMN LLISEQLEIP ENLLIDLSGL TALENQVASK LLAYVKETQM RDLSHLQEVE 

       250        260        270        280        290        300 
HYEIKDFLQM DFATKSSLEL TANKRENKKH GTLYWLLDET KTAMGTRMLR SWIDRPLISN 

       310        320        330        340        350        360 
SAIQKRMEIV QIFLDHFFER SDLIEALKGV YDLERLASRV SFGKAVPVDF LQLANSLSNV 

       370        380        390        400        410        420 
PAIKYILGML NEAPLEELKS QLDEIPELSG LINSAISENA SRTITEGGII KKGYNAQLDK 

       430        440        450        460        470        480 
YREALENGTS WIAKLEADEK AKTGISTLRI DYNRKDGYYF HITQSQLNSV PEHFYRKATL 

       490        500        510        520        530        540 
KNSERFGSQE LTEIEEIMLE AREKSSSLEY DLFMGLRTET EQYIGRLQAL AKTIAEIDCL 

       550        560        570        580        590        600 
QSLSVVAEKQ GYIRPTLTDG SRIVEIKGGR HAVVEAVMGA QEYVPNDIEL PEQTDIQLIT 

       610        620        630        640        650        660 
GPNMSGKSTY MRQFALTVIM AQIGSFVPAE TANLPIFDAI FTRIGASDNL ISGESTFMVE 

       670        680        690        700        710        720 
MSEANHAIQK ASSRSLIIFD ELGRGTATYD GMALAQAIIE YVHDHIGAKT LFATHYHELT 

       730        740        750        760        770        780 
DLDEALDHLD NVHVATLEQN GNVTFLHKIT EGPADKSYGI HVAKIAGLPQ PLLERADLIL 

       790        800        810        820        830        840 
QKLENKPLPA KKVADEQEQL SLFDFTENSS EIIEKIKRQN VDNMTAREAL NFLWELKDSL 

« Hide

References

[1]"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IL1403.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE005176 Genomic DNA. Translation: AAK06308.1.
PIRB86901.
RefSeqNP_268367.1. NC_002662.1.

3D structure databases

ProteinModelPortalQ9CDK9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272623.L0277.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK06308; AAK06308; L0277.
GeneID1115888.
KEGGlla:L0277.
PATRIC22296980. VBILacLac136773_2374.

Phylogenomic databases

eggNOGCOG0249.
HOGENOMHOG000221406.
KOK03555.
OMAMMAQYLE.
OrthoDBEOG6Q5NPV.
ProtClustDBPRK05399.

Enzyme and pathway databases

BioCycLLAC272623:GHSH-2351-MONOMER.

Family and domain databases

Gene3D3.30.420.110. 1 hit.
3.40.1170.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_00096. MutS.
InterProIPR005748. DNA_mismatch_repair_MutS-1.
IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR11361:SF34. PTHR11361:SF34. 1 hit.
PfamPF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
SMARTSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53150. SSF53150. 1 hit.
SSF55271. SSF55271. 1 hit.
TIGRFAMsTIGR01070. mutS1. 1 hit.
PROSITEPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMUTS_LACLA
AccessionPrimary (citable) accession number: Q9CDK9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: April 16, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families