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Protein

Prephenate dehydratase

Gene

pheA

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Prephenate = phenylpyruvate + H2O + CO2.

Pathwayi: L-phenylalanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes phenylpyruvate from prephenate.
Proteins known to be involved in this subpathway in this organism are:
  1. Prephenate dehydratase (pheA)
This subpathway is part of the pathway L-phenylalanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phenylpyruvate from prephenate, the pathway L-phenylalanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei184 – 1841Essential for activityBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Phenylalanine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00121; UER00345.

Names & Taxonomyi

Protein namesi
Recommended name:
Prephenate dehydratase (EC:4.2.1.51)
Short name:
PDT
Gene namesi
Name:pheA
Ordered Locus Names:ML0078
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0078.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 322322Prephenate dehydratasePRO_0000382035Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi272631.ML0078.

Structurei

3D structure databases

ProteinModelPortaliQ9CDC4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 191187Prephenate dehydratasePROSITE-ProRule annotationAdd
BLAST
Domaini205 – 28278ACTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ACT domain.PROSITE-ProRule annotation
Contains 1 prephenate dehydratase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105CQC. Bacteria.
COG0077. LUCA.
HOGENOMiHOG000018970.
KOiK04518.
OMAiEEWNITR.
OrthoDBiEOG6WHNT1.

Family and domain databases

InterProiIPR002912. ACT_dom.
IPR008242. Chor_mutase/pphenate_deHydtase.
IPR001086. Preph_deHydtase.
IPR018528. Preph_deHydtase_CS.
[Graphical view]
PfamiPF01842. ACT. 1 hit.
PF00800. PDT. 1 hit.
[Graphical view]
PIRSFiPIRSF001500. Chor_mut_pdt_Ppr. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
PS00858. PREPHENATE_DEHYDR_2. 1 hit.
PS51171. PREPHENATE_DEHYDR_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CDC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVARIAYLG PEGTFTEAAL LRMTAAGLVP DTGPDGLRRW PTESTPAALD
60 70 80 90 100
AVRGGAADYA CVPIENSIDG SVAPTLDNLA IGSPLQVFAE TTLDVEFNIV
110 120 130 140 150
VKPGITAADI RTLAAFPVAA AQVRQWLAAH LAGAELRPAY SNADAARQVA
160 170 180 190 200
YGQVDAAVTS PLAATRWGLI ALAAGIVDEP NARTRFVLVG MPGPPPARTG
210 220 230 240 250
TDRTSAVLRI DNAPGMLVAA LAEFGIRGID LTRIESRPTR TELGTYLFFV
260 270 280 290 300
DCVGHIDDGV VAEALKALHR RCADVCYLGS WPAGLATGPT VSPPPPDEAS
310 320
RWLARLRAGK PDQASEPGGG KL
Length:322
Mass (Da):33,549
Last modified:June 1, 2001 - v1
Checksum:i85C7FBB5866B8524
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583917 Genomic DNA. Translation: CAC29586.1.
PIRiF86918.
RefSeqiNP_301183.1. NC_002677.1.
WP_010907508.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC29586; CAC29586; CAC29586.
GeneIDi910395.
KEGGimle:ML0078.
PATRICi18050331. VBIMycLep78757_0122.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583917 Genomic DNA. Translation: CAC29586.1.
PIRiF86918.
RefSeqiNP_301183.1. NC_002677.1.
WP_010907508.1. NC_002677.1.

3D structure databases

ProteinModelPortaliQ9CDC4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML0078.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC29586; CAC29586; CAC29586.
GeneIDi910395.
KEGGimle:ML0078.
PATRICi18050331. VBIMycLep78757_0122.

Organism-specific databases

LepromaiML0078.

Phylogenomic databases

eggNOGiENOG4105CQC. Bacteria.
COG0077. LUCA.
HOGENOMiHOG000018970.
KOiK04518.
OMAiEEWNITR.
OrthoDBiEOG6WHNT1.

Enzyme and pathway databases

UniPathwayiUPA00121; UER00345.

Family and domain databases

InterProiIPR002912. ACT_dom.
IPR008242. Chor_mutase/pphenate_deHydtase.
IPR001086. Preph_deHydtase.
IPR018528. Preph_deHydtase_CS.
[Graphical view]
PfamiPF01842. ACT. 1 hit.
PF00800. PDT. 1 hit.
[Graphical view]
PIRSFiPIRSF001500. Chor_mut_pdt_Ppr. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
PS00858. PREPHENATE_DEHYDR_2. 1 hit.
PS51171. PREPHENATE_DEHYDR_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiPHEA_MYCLE
AccessioniPrimary (citable) accession number: Q9CDC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: June 1, 2001
Last modified: November 11, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.