Reviewed, UniProtKB/Swiss-Prot Q9CDA8 (EMBA_MYCLE)

Names and origin

Protein names

Recommended name:
    Probable arabinosyltransferase A
    EC=2.4.2.-

Gene names

Name:	embA
Ordered Locus Names:	ML0105

Organism

Mycobacterium leprae [Complete proteome] [HAMAP]

Taxonomic identifier

1769 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	1111 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein Probable.
Sequence similarities	Belongs to the emb family.

Ontologies

Keywords
Biological process	Cell wall biogenesis/degradation
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	transferase activity, transferring pentosyl groups Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1111	1111	Probable arabinosyltransferase A		PRO_0000220562
Regions
	Transmembrane	12 – 34	23	Potential
	Transmembrane	205 – 224	20	Potential
	Transmembrane	333 – 355	23	Potential
	Transmembrane	370 – 387	18	Potential
	Transmembrane	394 – 413	20	Potential
	Transmembrane	423 – 445	23	Potential
	Transmembrane	462 – 484	23	Potential
	Transmembrane	530 – 547	18	Potential
	Transmembrane	554 – 576	23	Potential
	Transmembrane	581 – 603	23	Potential
	Transmembrane	615 – 637	23	Potential
	Transmembrane	652 – 674	23	Potential
	Transmembrane	695 – 717	23	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9CDA8-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 221AE71109D1FA08	FASTA	1,111	118,489
	10 20 30 40 50 60 MPHDGHEPPQ RIIRLIAVGA GITGLLLCAV VPLLPVKQTT ATIRWPQSAT RDGWVTQITA 70 80 90 100 110 120 PLVSGTPRAL DISIPCSAMA TLPDSVGLVV STLPSGGVDT GKSGLFVRAN KNAVVVAFRD 130 140 150 160 170 180 SVAAVAPRPA VAAGNCSVLH IWANTRGAGA NFVGIPGAAG ILTAEKKPQV GGIFTDLKVP 190 200 210 220 230 240 VQPGLSAHID IDTRFITAPT AIKKIAVGVG AAAVLIAILA LSALDRRNRN GHRLINWRVS 250 260 270 280 290 300 MAWLAQWRVI LATPPRAGGA SRIADGGVLA TLLLWHIIGA TSSDDGYNLT VARVSSEAGY 310 320 330 340 350 360 LANYYRYFGA TEAPFDWYFT VLAKLASVST AGVWMRIPAT LAGIACWLII NHWVLRRLGP 370 380 390 400 410 420 GTGGLSTNRV AVLTAGAMFL AAWLPFNNGL RPEPLIALGV LFTWVLVERA IALRRLASAA 430 440 450 460 470 480 TAAVVAILTA TLAPQGLIAI AALLTGARAI TQTIRRRRTT DGLLAPLLVL AASLSLITLV 490 500 510 520 530 540 VFHSQTLATV GESARIKYKV GPTIACYQDF LRYYFLTVES NADGSMTRRF PVLVLLLCMF 550 560 570 580 590 600 GVLVVLLRRS RVPGLASGPT WRLIGTTATS LLLLTFTPTK WAIQFGALAG LTGTFGAIAA 610 620 630 640 650 660 FAFARISLHT RRNLTVYITA LLFVLAWATA GINGWFGVSN YGVPWFDIQP VIAGHPVTSI 670 680 690 700 710 720 FLTLSILTGL LAGGQHFRLD YAKHTEVKDT RRNRFLATTP LVVVATTMVL CEVGSLAKGA 730 740 750 760 770 780 VARYPLYTTA KANLAALRSG LAPSVCAMAD DVLTEPDPNA GMLQPVPGQI FGPTGPLGGM 790 800 810 820 830 840 NPIGFKPEGV NDDLKSDPVV SKPGLVNSDA SPNKPNVTFS DSAGTAGGKG PVGVNGSHVA 850 860 870 880 890 900 LPFGLDPDRT PVMGSYGENT LAASATSAWY QLPLHWKESI ADRPLVVVSA AGAIWSYKED 910 920 930 940 950 960 GNFIYGQSLK LQWGVTRPDG IIQPLAQVMP IDIGPQPAWR NLRFPLTWAP PEANVARVVA 970 980 990 1000 1010 1020 YDPNLSPDQW LAFTPPRVPV LQTLQQLLGS QTPVLMDIAT AANFPCQRPF SEHLGIAELP 1030 1040 1050 1060 1070 1080 QYRILPDHKQ TAASSNLWQS SEAGGPFLFL QALLRTSTIS TYLRDDWYRD WGSVEQYYRL 1090 1100 1110 VPADQAPEAV VKQGMITVPG WIRRGPIRAL P

References

[1]

"Massive gene decay in the leprosy bacillus." Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S. , Feltwell T., Fraser A., Hamlin N., Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S., Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R., Barrell B.G. Nature 409:1007-1011(2001) [PubMed: 11234002] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TN.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL583917 Genomic DNA. Translation: CAC29613.1.
PIR	A86922.
RefSeq	NP_301202.1.
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT53. Glycosyltransferase Family 53.
Genome annotation databases
GeneID	908337.
GenomeReviews	Gene locus ML0105 in contig AL450380_GR.
KEGG	mle:ML0105.
NMPDR	fig|272631.1.peg.74.
Organism-specific databases
Leproma	ML0105.
CMR	Search...
Phylogenomic databases
HOGENOM	Q9CDA8.
OMA	Q9CDA8. YYRYFGA.
Enzyme and pathway databases
BioCyc	MLEP272631:ML0105-MON.
Family and domain databases
InterPro	IPR007680. Arab_transf. [Graphical view]
Pfam	PF04602. Arabinose_trans. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EMBA_MYCLE

Accession

Primary (citable) accession number: Q9CDA8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	June 1, 2001
Last modified:	June 16, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)