Reviewed, UniProtKB/Swiss-Prot Q9CDA7 (EMBC_MYCLE)

Names and origin

Protein names

Recommended name:
    Probable arabinosyltransferase C
    EC=2.4.2.-

Gene names

Name:	embC
Ordered Locus Names:	ML0106

Organism

Mycobacterium leprae [Complete proteome] [HAMAP]

Taxonomic identifier

1769 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	1070 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein Probable.
Sequence similarities	Belongs to the emb family.

Ontologies

Keywords
Biological process	Cell wall biogenesis/degradation
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	transferase activity, transferring pentosyl groups Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1070	1070	Probable arabinosyltransferase C		PRO_0000220571
Regions
	Transmembrane	10 – 32	23	Potential
	Transmembrane	210 – 232	23	Potential
	Transmembrane	247 – 269	23	Potential
	Transmembrane	399 – 421	23	Potential
	Transmembrane	425 – 442	18	Potential
	Transmembrane	449 – 471	23	Potential
	Transmembrane	512 – 534	23	Potential
	Transmembrane	547 – 564	18	Potential
	Transmembrane	574 – 596	23	Potential
	Transmembrane	603 – 625	23	Potential
	Transmembrane	645 – 664	20	Potential
	Transmembrane	685 – 707	23	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9CDA7-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 46E10F02D49A93A3	FASTA	1,070	114,755
	10 20 30 40 50 60 MSGAGANYWI ARLLAVIAGL LGALLAMATP FLPVNQNTAQ LNWPQNSTFE SVEAPLIGYV 70 80 90 100 110 120 ATGLNVTVPC AAAAGLTGPQ SAGQTVLLST VPKQAPKAVD RGLLIQRAND DLVLVVRNVP 130 140 150 160 170 180 VVSAPMSQVL SPACQRLTFA AYFDKITAEF VGLTYGPNAE HPGVPLRGER SGYDFRPQIV 190 200 210 220 230 240 GVFTDLSGPI PTGLNFSATI DTRYSSSPTL LKTIAMILGV VLTIVALVAL HLLDTADGTQ 250 260 270 280 290 300 HRRLLPSRWW SIGCLDGLVI TILAWWHFVG ANTSDDGYIL TMARVSEHAG YMANYYRWFG 310 320 330 340 350 360 TPEAPFGWYY DLLALWAHVT TTSAWMRVPT LAMALTCWWL ISREVIPRLG HAAKASRAAA 370 380 390 400 410 420 WTAAGMFLAV WLPLDNGLRP EPIIALGILL TWCSVERAVA TSRLLPVAVA CIVGALTLFS 430 440 450 460 470 480 GPTGIASIGA LLVAVGPLLT ILQRRSKQFG AVPLVAPILA ASTVTAILIF RDQTFAGESQ 490 500 510 520 530 540 ASLLKRAVGP SLKWFDEHIR YERLFMASPD GSVARRFAVL ALLVALSVAV AMSLRKGRIP 550 560 570 580 590 600 GLAAGPSRRI IGITVTSFLA MMFTPTKWTH HFGVFAGLAG SLGALAAVAV ASAALRSRRN 610 620 630 640 650 660 RTVFAAVVLF VVALSFASVN GWWYVSNFGV PWSNSFPKLR WSLTTALLEL TVIVLLLAAW 670 680 690 700 710 720 FHFVATTNGS AKTRFGVRID RIVQSPIAIA TWSLVIFEVA SLTMAMIGQY PAWTVGKSNL 730 740 750 760 770 780 QALTGQTCGL AEEVLVEQDP NAGMLLPVST PVADALGSSL AEAFTANGIP ADVSADPVME 790 800 810 820 830 840 PPGDRSFVKE NGMTTGGEAG NEGGTNATPG INGSRAQLPY NLDPARTPVL GSWQSGIQVV 850 860 870 880 890 900 ARLRSGWYRL PARDKAGPLL VVSAAGRFDH HEVKLQWATD SGAASGQPGG AFQFSDVGAS 910 920 930 940 950 960 PAWRNLRLPL SAIPSMATQI RLVADDEDLA PQHWIALTPP RIPQLRTLQD VVGYQDPVFL 970 980 990 1000 1010 1020 DWLVGLAFPC QRPFDHQYGV DETPKWRILP DRFGAEANSP VMDNNGGGPL GVTELLLKAT 1030 1040 1050 1060 1070 TVASYLKDDW SRDWGALQRL TPYYPNAQPA RLSLGTTTRS GLWNPAPLRH

References

[1]

"Massive gene decay in the leprosy bacillus." Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S. , Feltwell T., Fraser A., Hamlin N., Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S., Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R., Barrell B.G. Nature 409:1007-1011(2001) [PubMed: 11234002] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TN.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL583917 Genomic DNA. Translation: CAC29614.1.
PIR	B86922.
RefSeq	NP_301203.1.
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT53. Glycosyltransferase Family 53.
Genome annotation databases
GeneID	908339.
GenomeReviews	Gene locus ML0106 in contig AL450380_GR.
KEGG	mle:ML0106.
NMPDR	fig|272631.1.peg.75.
Organism-specific databases
Leproma	ML0106.
CMR	Search...
Phylogenomic databases
HOGENOM	Q9CDA7.
OMA	Q9CDA7. SADPVME.
Enzyme and pathway databases
BioCyc	MLEP272631:ML0106-MON.
Family and domain databases
InterPro	IPR007680. Arab_transf. [Graphical view]
Pfam	PF04602. Arabinose_trans. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EMBC_MYCLE

Accession

Primary (citable) accession number: Q9CDA7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	June 1, 2001
Last modified:	June 16, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)