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Q9CD75 (G6PI_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:ML0150
OrganismMycobacterium leprae (strain TN) [Complete proteome] [HAMAP]
Taxonomic identifier272631 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length554 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 554554Glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_0000180674

Sites

Active site3581Proton donor By similarity
Active site3891 By similarity
Active site5151 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9CD75 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 013E1846AD893EA6

FASTA55460,634
        10         20         30         40         50         60 
MTSMQAIPDI TATPAWDALR RHHDEIGATH LRQFFADNPN RGRELVITVG DLYIDYSKHR 

        70         80         90        100        110        120 
ITHDTVQLLV DLARAANLEQ RRDQMLAGVH VNTSENRSVL HTALRLPRDT ELIVDGQNVV 

       130        140        150        160        170        180 
QDVHAVLDVM GDFTDRLRSG EWTGATGKRI NTVVNIGIGG SDLGPVMVYQ ALRHYADAGI 

       190        200        210        220        230        240 
SARFVSNIDP ADLTAKLSDL EPGTTLFIVA SKTFSTLETL TNATAARRWL TDALGEAAVS 

       250        260        270        280        290        300 
KHFVAVSTNK RLVKDFGINT ANMFGFWEWV GGRYSVDSAI GLSLMAVVGR ESFADFLSGF 

       310        320        330        340        350        360 
HIVDQHFQNA PLESNAPVLL GLIGLWYSDF LGAQSRAVLP YSNDLARFAA YLQQLTMESN 

       370        380        390        400        410        420 
GKSTRADGTP VTTNTGEIYW GETGTNGQHA FYQLLHQGTR LVPADFIGFS QPIDDLPTVD 

       430        440        450        460        470        480 
GIGSMHDLLM SNFFAQTQVL AFGKTAEEIA AEGTPAEVVP HKVMPGNRPT TSILANRLTP 

       490        500        510        520        530        540 
SVLGQLIALY EHQVFTEGVI WGIDSFDQWG VELGKKQAEA LLPVITGNAS PAQQLDSSTD 

       550 
TLVRRYRTER GRTS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL583917 Genomic DNA. Translation: CAC29658.1.
PIRF86927.
RefSeqNP_301236.1. NC_002677.1.

3D structure databases

ProteinModelPortalQ9CD75.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272631.ML0150.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC29658; CAC29658; CAC29658.
GeneID908501.
KEGGmle:ML0150.
PATRIC18050557. VBIMycLep78757_0232.

Organism-specific databases

LepromaML0150.
CMRSearch...

Phylogenomic databases

eggNOGCOG0166.
HOGENOMHOG000261371.
KOK01810.
OMANCHFVAN.
OrthoDBEOG64R61J.

Enzyme and pathway databases

UniPathwayUPA00109; UER00181.

Family and domain databases

Gene3D1.10.1390.10. 1 hit.
HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_MYCLE
AccessionPrimary (citable) accession number: Q9CD75
Entry history
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: June 1, 2001
Last modified: June 11, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways