Q9CD75 (G6PI_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	ML0150

Organism

Mycobacterium leprae [Complete proteome] [HAMAP]

Taxonomic identifier

1769 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	554 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 554	554	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_0000180674
Sites
	Active site	358	1	Proton donor By similarity
	Active site	389	1	By similarity
	Active site	515	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9CD75 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 013E1846AD893EA6	FASTA	554	60,634
	10 20 30 40 50 60 MTSMQAIPDI TATPAWDALR RHHDEIGATH LRQFFADNPN RGRELVITVG DLYIDYSKHR 70 80 90 100 110 120 ITHDTVQLLV DLARAANLEQ RRDQMLAGVH VNTSENRSVL HTALRLPRDT ELIVDGQNVV 130 140 150 160 170 180 QDVHAVLDVM GDFTDRLRSG EWTGATGKRI NTVVNIGIGG SDLGPVMVYQ ALRHYADAGI 190 200 210 220 230 240 SARFVSNIDP ADLTAKLSDL EPGTTLFIVA SKTFSTLETL TNATAARRWL TDALGEAAVS 250 260 270 280 290 300 KHFVAVSTNK RLVKDFGINT ANMFGFWEWV GGRYSVDSAI GLSLMAVVGR ESFADFLSGF 310 320 330 340 350 360 HIVDQHFQNA PLESNAPVLL GLIGLWYSDF LGAQSRAVLP YSNDLARFAA YLQQLTMESN 370 380 390 400 410 420 GKSTRADGTP VTTNTGEIYW GETGTNGQHA FYQLLHQGTR LVPADFIGFS QPIDDLPTVD 430 440 450 460 470 480 GIGSMHDLLM SNFFAQTQVL AFGKTAEEIA AEGTPAEVVP HKVMPGNRPT TSILANRLTP 490 500 510 520 530 540 SVLGQLIALY EHQVFTEGVI WGIDSFDQWG VELGKKQAEA LLPVITGNAS PAQQLDSSTD 550 TLVRRYRTER GRTS

References

[1]

"Massive gene decay in the leprosy bacillus." Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S. , Feltwell T., Fraser A., Hamlin N., Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S., Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R., Barrell B.G. Nature 409:1007-1011(2001) [PubMed: 11234002] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TN.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL583917 Genomic DNA. Translation: CAC29658.1.
PIR	F86927.
RefSeq	NP_301236.1. NC_002677.1.
3D structure databases
ProteinModelPortal	Q9CD75.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000029356; EBMYCP00000028962; EBMYCG00000029351.
GeneID	908501.
GenomeReviews	Gene locus ML0150 in contig AL450380_GR.
KEGG	mle:ML0150.
NMPDR	fig|272631.1.peg.108.
PATRIC	18050557. VBIMycLep78757_0232.
Organism-specific databases
Leproma	ML0150.
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000016991.
HOGENOM	HBG352954.
OMA	NSLPAWT.
ProtClustDB	PRK00179.
Enzyme and pathway databases
BioCyc	MLEP272631:ML0150-MONOMER.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR023096. G6P_Isomerase_C. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
Gene3D	G3DSA:1.10.1390.10. G6P_Isomerase_C. 1 hit.
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_MYCLE

Accession

Primary (citable) accession number: Q9CD75

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 2, 2001
Last sequence update:	June 1, 2001
Last modified:	January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program