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Q9CD75

- G6PI_MYCLE

UniProt

Q9CD75 - G6PI_MYCLE

Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei358 – 3581Proton donorBy similarity
    Active sitei389 – 3891By similarity
    Active sitei515 – 5151By similarity

    GO - Molecular functioni

    1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP
    2. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Gluconeogenesis, Glycolysis

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00181.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate isomerase (EC:5.3.1.9)
    Short name:
    GPI
    Alternative name(s):
    Phosphoglucose isomerase
    Short name:
    PGI
    Phosphohexose isomerase
    Short name:
    PHI
    Gene namesi
    Name:pgi
    Ordered Locus Names:ML0150
    OrganismiMycobacterium leprae (strain TN)
    Taxonomic identifieri272631 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000806: Chromosome

    Organism-specific databases

    LepromaiML0150.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 554554Glucose-6-phosphate isomerasePRO_0000180674Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272631.ML0150.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CD75.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GPI family.Curated

    Phylogenomic databases

    eggNOGiCOG0166.
    HOGENOMiHOG000261371.
    KOiK01810.
    OMAiNCHFVAN.
    OrthoDBiEOG64R61J.

    Family and domain databases

    Gene3Di1.10.1390.10. 1 hit.
    HAMAPiMF_00473. G6P_isomerase.
    InterProiIPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view]
    PANTHERiPTHR11469. PTHR11469. 1 hit.
    PfamiPF00342. PGI. 1 hit.
    [Graphical view]
    PRINTSiPR00662. G6PISOMERASE.
    PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9CD75-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSMQAIPDI TATPAWDALR RHHDEIGATH LRQFFADNPN RGRELVITVG    50
    DLYIDYSKHR ITHDTVQLLV DLARAANLEQ RRDQMLAGVH VNTSENRSVL 100
    HTALRLPRDT ELIVDGQNVV QDVHAVLDVM GDFTDRLRSG EWTGATGKRI 150
    NTVVNIGIGG SDLGPVMVYQ ALRHYADAGI SARFVSNIDP ADLTAKLSDL 200
    EPGTTLFIVA SKTFSTLETL TNATAARRWL TDALGEAAVS KHFVAVSTNK 250
    RLVKDFGINT ANMFGFWEWV GGRYSVDSAI GLSLMAVVGR ESFADFLSGF 300
    HIVDQHFQNA PLESNAPVLL GLIGLWYSDF LGAQSRAVLP YSNDLARFAA 350
    YLQQLTMESN GKSTRADGTP VTTNTGEIYW GETGTNGQHA FYQLLHQGTR 400
    LVPADFIGFS QPIDDLPTVD GIGSMHDLLM SNFFAQTQVL AFGKTAEEIA 450
    AEGTPAEVVP HKVMPGNRPT TSILANRLTP SVLGQLIALY EHQVFTEGVI 500
    WGIDSFDQWG VELGKKQAEA LLPVITGNAS PAQQLDSSTD TLVRRYRTER 550
    GRTS 554
    Length:554
    Mass (Da):60,634
    Last modified:June 1, 2001 - v1
    Checksum:i013E1846AD893EA6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL583917 Genomic DNA. Translation: CAC29658.1.
    PIRiF86927.
    RefSeqiNP_301236.1. NC_002677.1.
    WP_010907561.1. NC_002677.1.

    Genome annotation databases

    EnsemblBacteriaiCAC29658; CAC29658; CAC29658.
    GeneIDi908501.
    KEGGimle:ML0150.
    PATRICi18050557. VBIMycLep78757_0232.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL583917 Genomic DNA. Translation: CAC29658.1 .
    PIRi F86927.
    RefSeqi NP_301236.1. NC_002677.1.
    WP_010907561.1. NC_002677.1.

    3D structure databases

    ProteinModelPortali Q9CD75.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272631.ML0150.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC29658 ; CAC29658 ; CAC29658 .
    GeneIDi 908501.
    KEGGi mle:ML0150.
    PATRICi 18050557. VBIMycLep78757_0232.

    Organism-specific databases

    Lepromai ML0150.

    Phylogenomic databases

    eggNOGi COG0166.
    HOGENOMi HOG000261371.
    KOi K01810.
    OMAi NCHFVAN.
    OrthoDBi EOG64R61J.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00181 .

    Family and domain databases

    Gene3Di 1.10.1390.10. 1 hit.
    HAMAPi MF_00473. G6P_isomerase.
    InterProi IPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view ]
    PANTHERi PTHR11469. PTHR11469. 1 hit.
    Pfami PF00342. PGI. 1 hit.
    [Graphical view ]
    PRINTSi PR00662. G6PISOMERASE.
    PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TN.

    Entry informationi

    Entry nameiG6PI_MYCLE
    AccessioniPrimary (citable) accession number: Q9CD75
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 2, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3