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Protein

ATP-dependent DNA helicase UvrD1

Gene

uvrD

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA-dependent ATPase, acting on dsDNA with a 3'-ssDNA tail, unwinding with 3'-to 5'-polarity. Also highly efficient on nicked DNA. Involved in the post-incision events of nucleotide excision repair (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei311ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi43 – 48ATPPROSITE-ProRule annotation6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent DNA helicase UvrD1 (EC:3.6.4.12)
Gene namesi
Name:uvrD
Ordered Locus Names:ML0153
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0153.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001020541 – 778ATP-dependent DNA helicase UvrD1Add BLAST778

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi272631.ML0153.

Structurei

3D structure databases

ProteinModelPortaliQ9CD72.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 313UvrD-like helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST295
Domaini314 – 610UvrD-like helicase C-terminalPROSITE-ProRule annotationAdd BLAST297

Sequence similaritiesi

Belongs to the helicase family. UvrD subfamily.Curated
Contains 1 uvrD-like helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 uvrD-like helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105C4R. Bacteria.
COG0210. LUCA.
HOGENOMiHOG000033016.
KOiK03657.
OMAiRLQIAFQ.
OrthoDBiPOG091H01Y3.

Family and domain databases

Gene3Di1.10.10.160. 1 hit.
3.40.50.300. 4 hits.
InterProiIPR013986. DExx_box_DNA_helicase_dom.
IPR014017. DNA_helicase_UvrD-like_C.
IPR000212. DNA_helicase_UvrD/REP.
IPR027417. P-loop_NTPase.
IPR014016. UvrD-like_ATP-bd.
[Graphical view]
PANTHERiPTHR11070. PTHR11070. 2 hits.
PfamiPF00580. UvrD-helicase. 1 hit.
PF13361. UvrD_C. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51198. UVRD_HELICASE_ATP_BIND. 1 hit.
PS51217. UVRD_HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CD72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVHTTDAKP DSEVDRLLDG LNPQQRQAVV HEGSPLLIVA GAGSGKTTVL
60 70 80 90 100
ARRIAYLIAA RSVGVSQILA ITFTNKAAAE MRERVARLVG DHTGPSMWVS
110 120 130 140 150
TFHSTCVRIL RNQASLIGGL NSNFSIYDVD DSRSLLQMIG QDMGLDIKRY
160 170 180 190 200
SPRLMANAIS NLKNELIDAE SAVANLSSDT DDLARTVATV YGEYQRRLRT
210 220 230 240 250
ANALDFDDLI GETVGILQAF PQIAEHYRRR FRHVLVDEYQ DTNHAQYVLV
260 270 280 290 300
RELVGHGARN SPDDMPPGEL CVVGDADQSI YAFRGSTISN IEDFERDYPD
310 320 330 340 350
TTTILLEQNY RSTQNILSAA NSVIARNFGR RDKRLWTDAG KGELIVGYVS
360 370 380 390 400
DNEHDEAKFI ADEIDALVGG GEITYDDVAV LYRANNLSRS LEEVFIPTGI
410 420 430 440 450
PYKVVGGFCF YESKEIRDLI AYLRVLDNPG DAVSMRRILN TPRRGIGDRA
460 470 480 490 500
EACVSVYAEN TGTSFADALQ AVAEGKVPML NTRSVKAIAG FVALLDDLRC
510 520 530 540 550
RVDDDLGELV ESVLERSGYL RELESSTDPQ ELARLDNLNE LVSFAHEFST
560 570 580 590 600
EQANAAALAK SLHTPEDEDV PDTGALAAFL EKVSLMSDTD QIPENNSGVV
610 620 630 640 650
TLMTLHAAKG LEFPVVFVTG WEDGMLPHMR TLGDPTELSE ERRLAYVGIT
660 670 680 690 700
RARQRLYLSR AITRSSWGQP ILNPESRFLR EIPPELIDWR RSILTDSYST
710 720 730 740 750
PASGASRFGR VRPSSIRSGA SKRALLVLAP GDRVTHDKYG LGRVEEVSGV
760 770
GESAISLIDF GSSGRIKLMH NHAPVTKL
Length:778
Mass (Da):85,635
Last modified:April 27, 2001 - v1
Checksum:i3964DF128E008EF6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583917 Genomic DNA. Translation: CAC29661.1.
PIRiA86928.
RefSeqiNP_301239.1. NC_002677.1.
WP_010907564.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC29661; CAC29661; CAC29661.
GeneIDi908505.
KEGGimle:ML0153.
PATRICi18050567. VBIMycLep78757_0237.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583917 Genomic DNA. Translation: CAC29661.1.
PIRiA86928.
RefSeqiNP_301239.1. NC_002677.1.
WP_010907564.1. NC_002677.1.

3D structure databases

ProteinModelPortaliQ9CD72.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML0153.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC29661; CAC29661; CAC29661.
GeneIDi908505.
KEGGimle:ML0153.
PATRICi18050567. VBIMycLep78757_0237.

Organism-specific databases

LepromaiML0153.

Phylogenomic databases

eggNOGiENOG4105C4R. Bacteria.
COG0210. LUCA.
HOGENOMiHOG000033016.
KOiK03657.
OMAiRLQIAFQ.
OrthoDBiPOG091H01Y3.

Family and domain databases

Gene3Di1.10.10.160. 1 hit.
3.40.50.300. 4 hits.
InterProiIPR013986. DExx_box_DNA_helicase_dom.
IPR014017. DNA_helicase_UvrD-like_C.
IPR000212. DNA_helicase_UvrD/REP.
IPR027417. P-loop_NTPase.
IPR014016. UvrD-like_ATP-bd.
[Graphical view]
PANTHERiPTHR11070. PTHR11070. 2 hits.
PfamiPF00580. UvrD-helicase. 1 hit.
PF13361. UvrD_C. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51198. UVRD_HELICASE_ATP_BIND. 1 hit.
PS51217. UVRD_HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUVRD1_MYCLE
AccessioniPrimary (citable) accession number: Q9CD72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: September 7, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.