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Protein

Type III pantothenate kinase

Gene

coaX

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.UniRule annotation

Catalytic activityi

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.UniRule annotation

Cofactori

NH4(+)UniRule annotation, K+UniRule annotationNote: A monovalent cation. Ammonium or potassium.UniRule annotation

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Type III pantothenate kinase (coaX), Pantothenate kinase (coaA)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei111 – 1111Proton acceptorUniRule annotation
Metal bindingi131 – 1311Monovalent cationUniRule annotation
Binding sitei134 – 1341ATPUniRule annotation
Binding sitei186 – 1861SubstrateUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi6 – 138ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Potassium

Enzyme and pathway databases

UniPathwayiUPA00241; UER00352.

Names & Taxonomyi

Protein namesi
Recommended name:
Type III pantothenate kinaseUniRule annotation (EC:2.7.1.33UniRule annotation)
Alternative name(s):
PanK-IIIUniRule annotation
Pantothenic acid kinaseUniRule annotation
Gene namesi
Name:coaXUniRule annotation
Ordered Locus Names:ML0232
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0232.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 274274Type III pantothenate kinasePRO_0000267563Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272631.ML0232.

Structurei

3D structure databases

ProteinModelPortaliQ9CD56.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni109 – 1124Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the type III pantothenate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CGM. Bacteria.
COG1521. LUCA.
HOGENOMiHOG000066025.
KOiK03525.
OMAiHEPWLTL.
OrthoDBiPOG091H01V7.

Family and domain databases

HAMAPiMF_01274. Pantothen_kinase_3. 1 hit.
InterProiIPR004619. Type_III_PanK.
[Graphical view]
PfamiPF03309. Pan_kinase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00671. baf. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CD56-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLAIDVRNT HTVVGLLSGS KEHAKVVQQW RIRTESEVTA DELALIIDGL
60 70 80 90 100
IGDDSERLAG AAALSTVPSV LHEVRIMLDQ YWPSVPHVLI EPGVRTGIPL
110 120 130 140 150
LVDNPKEVGA DRIVNCLAAF HKFGQAAIVV DFGSSICVDV VSAKGEFLGG
160 170 180 190 200
AIAPGVQVSS DAAAARSAAL RRVELARPRS VVGKNTVECM QAGVVFGFAG
210 220 230 240 250
LVDGLVGRMR QDVEEFSGDL GNRVAVVATG HTAPLLLPEL HTVDHYDRHL
260 270
TLHGLRLVFE RNREAQRGRL KTAR
Length:274
Mass (Da):29,421
Last modified:June 1, 2001 - v1
Checksum:i1C2E735BDEC78765
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583917 Genomic DNA. Translation: CAC29740.1.
PIRiH86937.
RefSeqiNP_301292.1. NC_002677.1.
WP_010907616.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC29740; CAC29740; CAC29740.
GeneIDi908665.
KEGGimle:ML0232.
PATRICi18050828. VBIMycLep78757_0365.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583917 Genomic DNA. Translation: CAC29740.1.
PIRiH86937.
RefSeqiNP_301292.1. NC_002677.1.
WP_010907616.1. NC_002677.1.

3D structure databases

ProteinModelPortaliQ9CD56.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML0232.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC29740; CAC29740; CAC29740.
GeneIDi908665.
KEGGimle:ML0232.
PATRICi18050828. VBIMycLep78757_0365.

Organism-specific databases

LepromaiML0232.

Phylogenomic databases

eggNOGiENOG4105CGM. Bacteria.
COG1521. LUCA.
HOGENOMiHOG000066025.
KOiK03525.
OMAiHEPWLTL.
OrthoDBiPOG091H01V7.

Enzyme and pathway databases

UniPathwayiUPA00241; UER00352.

Family and domain databases

HAMAPiMF_01274. Pantothen_kinase_3. 1 hit.
InterProiIPR004619. Type_III_PanK.
[Graphical view]
PfamiPF03309. Pan_kinase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00671. baf. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOAX_MYCLE
AccessioniPrimary (citable) accession number: Q9CD56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.