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Protein

Type III pantothenate kinase

Gene

coaX

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.UniRule annotation

Catalytic activityi

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.UniRule annotation

Cofactori

NH4(+)UniRule annotation, K+UniRule annotationNote: A monovalent cation. Ammonium or potassium.UniRule annotation

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Type III pantothenate kinase (coaX), Pantothenate kinase (coaA)
  2. Coenzyme A biosynthesis bifunctional protein CoaBC (dfp)
  3. Coenzyme A biosynthesis bifunctional protein CoaBC (dfp)
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei111Proton acceptorUniRule annotation1
Metal bindingi131Monovalent cationUniRule annotation1
Binding sitei134ATPUniRule annotation1
Binding sitei186SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi6 – 13ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processCoenzyme A biosynthesis
LigandATP-binding, Metal-binding, Nucleotide-binding, Potassium

Enzyme and pathway databases

BioCyciMLEP272631:G1GT5-263-MONOMER
UniPathwayiUPA00241; UER00352

Names & Taxonomyi

Protein namesi
Recommended name:
Type III pantothenate kinaseUniRule annotation (EC:2.7.1.33UniRule annotation)
Alternative name(s):
PanK-IIIUniRule annotation
Pantothenic acid kinaseUniRule annotation
Gene namesi
Name:coaXUniRule annotation
Ordered Locus Names:ML0232
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0232

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002675631 – 274Type III pantothenate kinaseAdd BLAST274

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272631.ML0232

Structurei

3D structure databases

ProteinModelPortaliQ9CD56
SMRiQ9CD56
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni109 – 112Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the type III pantothenate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CGM Bacteria
COG1521 LUCA
HOGENOMiHOG000066025
KOiK03525
OMAiHEPWLTL
OrthoDBiPOG091H01V7

Family and domain databases

HAMAPiMF_01274 Pantothen_kinase_3, 1 hit
InterProiView protein in InterPro
IPR004619 Type_III_PanK
PANTHERiPTHR34265 PTHR34265, 1 hit
PfamiView protein in Pfam
PF03309 Pan_kinase, 1 hit
TIGRFAMsiTIGR00671 baf, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CD56-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLAIDVRNT HTVVGLLSGS KEHAKVVQQW RIRTESEVTA DELALIIDGL
60 70 80 90 100
IGDDSERLAG AAALSTVPSV LHEVRIMLDQ YWPSVPHVLI EPGVRTGIPL
110 120 130 140 150
LVDNPKEVGA DRIVNCLAAF HKFGQAAIVV DFGSSICVDV VSAKGEFLGG
160 170 180 190 200
AIAPGVQVSS DAAAARSAAL RRVELARPRS VVGKNTVECM QAGVVFGFAG
210 220 230 240 250
LVDGLVGRMR QDVEEFSGDL GNRVAVVATG HTAPLLLPEL HTVDHYDRHL
260 270
TLHGLRLVFE RNREAQRGRL KTAR
Length:274
Mass (Da):29,421
Last modified:June 1, 2001 - v1
Checksum:i1C2E735BDEC78765
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583917 Genomic DNA Translation: CAC29740.1
PIRiH86937
RefSeqiNP_301292.1, NC_002677.1
WP_010907616.1, NC_002677.1

Genome annotation databases

EnsemblBacteriaiCAC29740; CAC29740; CAC29740
GeneIDi908665
KEGGimle:ML0232
PATRICifig|272631.5.peg.365

Similar proteinsi

Entry informationi

Entry nameiCOAX_MYCLE
AccessioniPrimary (citable) accession number: Q9CD56
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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