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Q9CCZ9

- TRMB_MYCLE

UniProt

Q9CCZ9 - TRMB_MYCLE

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei61 – 611S-adenosyl-L-methionineUniRule annotation
    Binding sitei86 – 861S-adenosyl-L-methionineUniRule annotation
    Binding sitei113 – 1131S-adenosyl-L-methionineUniRule annotation
    Active sitei136 – 1361By similarity
    Binding sitei136 – 1361S-adenosyl-L-methionineUniRule annotation
    Binding sitei140 – 1401SubstrateUniRule annotation
    Binding sitei172 – 1721SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:ML2622
    ORF Names:MLCL622.20c
    OrganismiMycobacterium leprae (strain TN)
    Taxonomic identifieri272631 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000806: Chromosome

    Organism-specific databases

    LepromaiML2622.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 230230tRNA (guanine-N(7)-)-methyltransferasePRO_0000171354Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272631.ML2622.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CCZ9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni208 – 2114Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000073968.
    KOiK03439.
    OMAiFATDWEN.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9CCZ9-1 [UniParc]FASTAAdd to Basket

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    MARHLPATAF RKRRSALSHA QRQTWERLWP EIGISAVSQT RSAERLDTGA    50
    WFGRSTLVVL EVGCGSGTAT LAMAQHEPDI DVIAVEVYRR GLAQLLCAID 100
    RDQVHNIRMI HGNALYVLQY LIAPRSLTGV RVFFPDPWPK VRHHKRRFLQ 150
    PATVELIADR LLPGGVLHTA TDHPDYAKQI AKFGDGEPLL SRADGRTQLP 200
    ISTVRPTTKY ETKAQHAGNV VTELIWKKRS 230
    Length:230
    Mass (Da):25,821
    Last modified:June 1, 2001 - v1
    Checksum:i082DD06A64624D7B
    GO

    Sequence cautioni

    The sequence CAB08804.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z95398 Genomic DNA. Translation: CAB08804.1. Different initiation.
    AL583926 Genomic DNA. Translation: CAC32154.1.
    PIRiD87237.
    RefSeqiNP_302680.1. NC_002677.1.
    WP_010908999.1. NC_002677.1.

    Genome annotation databases

    EnsemblBacteriaiCAC32154; CAC32154; CAC32154.
    GeneIDi910881.
    KEGGimle:ML2622.
    PATRICi18060219. VBIMycLep78757_5023.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z95398 Genomic DNA. Translation: CAB08804.1 . Different initiation.
    AL583926 Genomic DNA. Translation: CAC32154.1 .
    PIRi D87237.
    RefSeqi NP_302680.1. NC_002677.1.
    WP_010908999.1. NC_002677.1.

    3D structure databases

    ProteinModelPortali Q9CCZ9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272631.ML2622.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC32154 ; CAC32154 ; CAC32154 .
    GeneIDi 910881.
    KEGGi mle:ML2622.
    PATRICi 18060219. VBIMycLep78757_5023.

    Organism-specific databases

    Lepromai ML2622.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000073968.
    KOi K03439.
    OMAi FATDWEN.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TN.

    Entry informationi

    Entry nameiTRMB_MYCLE
    AccessioniPrimary (citable) accession number: Q9CCZ9
    Secondary accession number(s): O06083
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3