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Q9CCZ9

- TRMB_MYCLE

UniProt

Q9CCZ9 - TRMB_MYCLE

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene
trmB, ML2622, MLCL622.20c
Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei61 – 611S-adenosyl-L-methionine By similarity
Binding sitei86 – 861S-adenosyl-L-methionine By similarity
Binding sitei113 – 1131S-adenosyl-L-methionine By similarity
Active sitei136 – 1361 By similarity
Binding sitei136 – 1361S-adenosyl-L-methionine By similarity
Binding sitei140 – 1401Substrate By similarity
Binding sitei172 – 1721Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:ML2622
ORF Names:MLCL622.20c
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML2622.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 230230tRNA (guanine-N(7)-)-methyltransferaseUniRule annotationPRO_0000171354Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272631.ML2622.

Structurei

3D structure databases

ProteinModelPortaliQ9CCZ9.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni208 – 2114Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000073968.
KOiK03439.
OMAiFATDWEN.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CCZ9-1 [UniParc]FASTAAdd to Basket

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MARHLPATAF RKRRSALSHA QRQTWERLWP EIGISAVSQT RSAERLDTGA    50
WFGRSTLVVL EVGCGSGTAT LAMAQHEPDI DVIAVEVYRR GLAQLLCAID 100
RDQVHNIRMI HGNALYVLQY LIAPRSLTGV RVFFPDPWPK VRHHKRRFLQ 150
PATVELIADR LLPGGVLHTA TDHPDYAKQI AKFGDGEPLL SRADGRTQLP 200
ISTVRPTTKY ETKAQHAGNV VTELIWKKRS 230
Length:230
Mass (Da):25,821
Last modified:June 1, 2001 - v1
Checksum:i082DD06A64624D7B
GO

Sequence cautioni

The sequence CAB08804.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z95398 Genomic DNA. Translation: CAB08804.1. Different initiation.
AL583926 Genomic DNA. Translation: CAC32154.1.
PIRiD87237.
RefSeqiNP_302680.1. NC_002677.1.
WP_010908999.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC32154; CAC32154; CAC32154.
GeneIDi910881.
KEGGimle:ML2622.
PATRICi18060219. VBIMycLep78757_5023.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z95398 Genomic DNA. Translation: CAB08804.1 . Different initiation.
AL583926 Genomic DNA. Translation: CAC32154.1 .
PIRi D87237.
RefSeqi NP_302680.1. NC_002677.1.
WP_010908999.1. NC_002677.1.

3D structure databases

ProteinModelPortali Q9CCZ9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272631.ML2622.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC32154 ; CAC32154 ; CAC32154 .
GeneIDi 910881.
KEGGi mle:ML2622.
PATRICi 18060219. VBIMycLep78757_5023.

Organism-specific databases

Lepromai ML2622.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000073968.
KOi K03439.
OMAi FATDWEN.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiTRMB_MYCLE
AccessioniPrimary (citable) accession number: Q9CCZ9
Secondary accession number(s): O06083
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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