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Protein

Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640

Gene

ML2640

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei132 – 1321S-adenosyl-L-methionine1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 (EC:2.1.1.-)
Gene namesi
Ordered Locus Names:ML2640
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML2640.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640PRO_0000356894Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272631.ML2640.

Structurei

Secondary structure

1
310
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi16 – 2914Combined sources
Helixi41 – 466Combined sources
Helixi53 – 564Combined sources
Helixi60 – 623Combined sources
Helixi63 – 697Combined sources
Helixi71 – 10030Combined sources
Beta strandi105 – 1095Combined sources
Helixi116 – 1194Combined sources
Beta strandi127 – 1326Combined sources
Helixi134 – 14613Combined sources
Beta strandi152 – 1598Combined sources
Helixi166 – 1727Combined sources
Beta strandi181 – 1855Combined sources
Helixi189 – 1913Combined sources
Helixi194 – 20613Combined sources
Beta strandi213 – 2175Combined sources
Helixi225 – 23814Combined sources
Turni253 – 2564Combined sources
Helixi262 – 2665Combined sources
Turni267 – 2704Combined sources
Beta strandi271 – 2777Combined sources
Helixi278 – 2847Combined sources
Turni293 – 2964Combined sources
Helixi298 – 3003Combined sources
Beta strandi303 – 3097Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CKDX-ray2.80A/B1-310[»]
2UYOX-ray1.70A1-310[»]
2UYQX-ray1.80A1-310[»]
ProteinModelPortaliQ9CCZ4.
SMRiQ9CCZ4. Positions 8-310.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9CCZ4.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni161 – 1622S-adenosyl-L-methionine binding

Sequence similaritiesi

Belongs to the UPF0677 family.Curated

Phylogenomic databases

eggNOGiENOG4108UGJ. Bacteria.
COG3315. LUCA.
HOGENOMiHOG000240238.
OMAiELTYEDP.
OrthoDBiPOG091H0AYD.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR011610. CHP00027_methylltransferase.
IPR007213. Ppm1/Ppm2/Tcmp.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR13600. PTHR13600. 1 hit.
PfamiPF04072. LCM. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00027. mthyl_TIGR00027. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CCZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTHDDTWDI KTSVGTTAVM VAAARAAETD RPDALIRDPY AKLLVTNTGA
60 70 80 90 100
GALWEAMLDP SMVAKVEAID AEAAAMVEHM RSYQAVRTNF FDTYFNNAVI
110 120 130 140 150
DGIRQFVILA SGLDSRAYRL DWPTGTTVYE IDQPKVLAYK STTLAEHGVT
160 170 180 190 200
PTADRREVPI DLRQDWPPAL RSAGFDPSAR TAWLAEGLLM YLPATAQDGL
210 220 230 240 250
FTEIGGLSAV GSRIAVETSP LHGDEWREQM QLRFRRVSDA LGFEQAVDVQ
260 270 280 290 300
ELIYHDENRA VVADWLNRHG WRATAQSAPD EMRRVGRWGD GVPMADDKDA
310
FAEFVTAHRL
Length:310
Mass (Da):34,454
Last modified:June 1, 2001 - v1
Checksum:i076DCA5DBB1DF78D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583926 Genomic DNA. Translation: CAC32172.1.
PIRiF87239.
RefSeqiNP_302690.1. NC_002677.1.
WP_010909009.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC32172; CAC32172; CAC32172.
GeneIDi910852.
KEGGimle:ML2640.
PATRICi18060307. VBIMycLep78757_5067.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583926 Genomic DNA. Translation: CAC32172.1.
PIRiF87239.
RefSeqiNP_302690.1. NC_002677.1.
WP_010909009.1. NC_002677.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CKDX-ray2.80A/B1-310[»]
2UYOX-ray1.70A1-310[»]
2UYQX-ray1.80A1-310[»]
ProteinModelPortaliQ9CCZ4.
SMRiQ9CCZ4. Positions 8-310.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML2640.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC32172; CAC32172; CAC32172.
GeneIDi910852.
KEGGimle:ML2640.
PATRICi18060307. VBIMycLep78757_5067.

Organism-specific databases

LepromaiML2640.

Phylogenomic databases

eggNOGiENOG4108UGJ. Bacteria.
COG3315. LUCA.
HOGENOMiHOG000240238.
OMAiELTYEDP.
OrthoDBiPOG091H0AYD.

Miscellaneous databases

EvolutionaryTraceiQ9CCZ4.
PROiQ9CCZ4.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR011610. CHP00027_methylltransferase.
IPR007213. Ppm1/Ppm2/Tcmp.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR13600. PTHR13600. 1 hit.
PfamiPF04072. LCM. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00027. mthyl_TIGR00027. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiY2640_MYCLE
AccessioniPrimary (citable) accession number: Q9CCZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.