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Q9CCS6 (AROC_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Chorismate synthase
EC=4.2.3.5
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase
Gene names
Name:aroC
Synonyms:aroF
Ordered Locus Names:ML0516
OrganismMycobacterium leprae [Complete proteome] [HAMAP]
Taxonomic identifier1769 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length407 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300

Cofactor

Reduced flavin By similarity. HAMAP MF_00300

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300

Subunit structure

Homotetramer By similarity. HAMAP MF_00300

Sequence similarities

Belongs to the chorismate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionchorismate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 407407Chorismate synthase HAMAP MF_00300
PRO_0000140613

Sequences

Sequence LengthMass (Da)Tools
Q9CCS6 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 1F677D07ADB556AF

FASTA40742,473
        10         20         30         40         50         60 
MLRWITAGES HGRALVAVVE GMVAGVEVTS TAIADQLARR RLGYGRGARM AFERDGVTVL 

        70         80         90        100        110        120 
SGVRHGVTLG GPIAIEIDNT EWPKWESVMA ADPVDAAELE DSARNAPLTR PRPGHADYAG 

       130        140        150        160        170        180 
MLKYGFDDAR PVLERASARE TAARVAAGTI ARQFLRQALG VEVLSHVISI GASARYDGPP 

       190        200        210        220        230        240 
PGSEDLTVID ASLVRAFDEQ VEKSMIAEIE AAKKDGDTLG GVVEAVVLGL PVGLGSFTSG 

       250        260        270        280        290        300 
DDRLDSQLAA AVMGIQAIKG VEIGDGFATA RRRGSCAHDE MYSGPGGVVR LTNRSGGLEG 

       310        320        330        340        350        360 
GMTNGQPLRV RAAMKPISTV PRALATVDLA TGEEAIAIHQ RSDVCAVPAA GVVVETMVAL 

       370        380        390        400 
VLARAALRKF GGDSLGETRR NLAAYQRAVA DREAPVAQYC GESGIGG

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL583918 Genomic DNA. Translation: CAC30024.1.
PIRD86973.
RefSeqNP_301441.1. NC_002677.1.

3D structure databases

ProteinModelPortalQ9CCS6.
SMRQ9CCS6. Positions 1-392.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000029263; EBMYCP00000028869; EBMYCG00000029258.
GeneID909273.
GenomeReviewsGene locus ML0516 in contig AL450380_GR.
KEGGmle:ML0516.
NMPDRfig|272631.1.peg.313.
PATRIC18051916. VBIMycLep78757_0905.

Organism-specific databases

LepromaML0516.
CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000016560.
HOGENOMHBG292336.
OMAMLRWLTA.
ProtClustDBPRK05382.

Enzyme and pathway databases

BioCycMLEP272631:ML0516-MONOMER.

Family and domain databases

HAMAPMF_00300. Chorismate_synth.
[Tree]
InterProIPR000453. Chorismate_synth.
IPR020541. Chorismate_synthase_CS.
[Graphical view]
KOK01736.
PANTHERPTHR21085. Chorismate_synth. 1 hit.
PfamPF01264. Chorismate_synt. 1 hit.
[Graphical view]
PIRSFPIRSF001456. Chorismate_synth. 1 hit.
SUPFAMSSF103263. Chorismate_synth. 1 hit.
TIGRFAMsTIGR00033. AroC. 1 hit.
PROSITEPS00787. CHORISMATE_SYNTHASE_1. 1 hit.
PS00788. CHORISMATE_SYNTHASE_2. 1 hit.
PS00789. CHORISMATE_SYNTHASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROC_MYCLE
AccessionPrimary (citable) accession number: Q9CCS6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: June 1, 2001
Last modified: January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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