Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9CCS5

- AROK_MYCLE

UniProt

Q9CCS5 - AROK_MYCLE

Protein

Shikimate kinase

Gene

aroK

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.UniRule annotation

    Catalytic activityi

    ATP + shikimate = ADP + shikimate 3-phosphate.UniRule annotation

    Cofactori

    Binds 1 magnesium ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi16 – 161MagnesiumUniRule annotation
    Binding sitei34 – 341SubstrateUniRule annotation
    Binding sitei58 – 581SubstrateUniRule annotation
    Binding sitei80 – 801Substrate; via amide nitrogenUniRule annotation
    Binding sitei117 – 1171ATPUniRule annotation
    Binding sitei136 – 1361SubstrateUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 176ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. shikimate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic amino acid family biosynthetic process Source: UniProtKB-HAMAP
    2. chorismate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00053; UER00088.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Shikimate kinaseUniRule annotation (EC:2.7.1.71UniRule annotation)
    Short name:
    SKUniRule annotation
    Gene namesi
    Name:aroKUniRule annotation
    Ordered Locus Names:ML0517
    OrganismiMycobacterium leprae (strain TN)
    Taxonomic identifieri272631 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000806: Chromosome

    Organism-specific databases

    LepromaiML0517.

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 199199Shikimate kinasePRO_0000192392Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi272631.ML0517.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CCS5.
    SMRiQ9CCS5. Positions 2-167.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the shikimate kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0703.
    HOGENOMiHOG000032568.
    KOiK00891.
    OMAiADIPWIF.
    OrthoDBiEOG6SJJGD.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00109. Shikimate_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR000623. Shikimate_kinase/TSH1.
    IPR023000. Shikimate_kinase_CS.
    [Graphical view]
    PfamiPF01202. SKI. 1 hit.
    [Graphical view]
    PRINTSiPR01100. SHIKIMTKNASE.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS01128. SHIKIMATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9CCS5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPKAVLVGL PGAGKSTIGR RLSKALGVSL LDTDAAIEKQ TGRSIADIFA    50
    IDGEEEFRRI EEGVVRAALV EHDGVVSLGG GAVTSPGVCA ALAGHIVIYL 100
    EINAEEAMRR ACGSTVRPLL AGPDRAEKFQ DLMARRVPLY RRVATIRVDT 150
    NCHNLGAVVR YIMARLQAQL ATPVSGGDRK SSEAERSGAP LRKSSEVVK 199
    Length:199
    Mass (Da):21,084
    Last modified:June 1, 2001 - v1
    Checksum:iFCA4D829CB520477
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL583918 Genomic DNA. Translation: CAC30025.1.
    PIRiE86973.
    RefSeqiNP_301442.1. NC_002677.1.
    WP_010907766.1. NC_002677.1.

    Genome annotation databases

    EnsemblBacteriaiCAC30025; CAC30025; CAC30025.
    GeneIDi909274.
    KEGGimle:ML0517.
    PATRICi18051918. VBIMycLep78757_0906.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL583918 Genomic DNA. Translation: CAC30025.1 .
    PIRi E86973.
    RefSeqi NP_301442.1. NC_002677.1.
    WP_010907766.1. NC_002677.1.

    3D structure databases

    ProteinModelPortali Q9CCS5.
    SMRi Q9CCS5. Positions 2-167.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272631.ML0517.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC30025 ; CAC30025 ; CAC30025 .
    GeneIDi 909274.
    KEGGi mle:ML0517.
    PATRICi 18051918. VBIMycLep78757_0906.

    Organism-specific databases

    Lepromai ML0517.

    Phylogenomic databases

    eggNOGi COG0703.
    HOGENOMi HOG000032568.
    KOi K00891.
    OMAi ADIPWIF.
    OrthoDBi EOG6SJJGD.

    Enzyme and pathway databases

    UniPathwayi UPA00053 ; UER00088 .

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00109. Shikimate_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR000623. Shikimate_kinase/TSH1.
    IPR023000. Shikimate_kinase_CS.
    [Graphical view ]
    Pfami PF01202. SKI. 1 hit.
    [Graphical view ]
    PRINTSi PR01100. SHIKIMTKNASE.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS01128. SHIKIMATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TN.

    Entry informationi

    Entry nameiAROK_MYCLE
    AccessioniPrimary (citable) accession number: Q9CCS5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3