Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9CCS5

- AROK_MYCLE

UniProt

Q9CCS5 - AROK_MYCLE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Shikimate kinase

Gene

aroK

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.UniRule annotation

Catalytic activityi

ATP + shikimate = ADP + shikimate 3-phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg(2+) ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi16 – 161MagnesiumUniRule annotation
Binding sitei34 – 341SubstrateUniRule annotation
Binding sitei58 – 581SubstrateUniRule annotation
Binding sitei80 – 801Substrate; via amide nitrogenUniRule annotation
Binding sitei117 – 1171ATPUniRule annotation
Binding sitei136 – 1361SubstrateUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 176ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. shikimate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic amino acid family biosynthetic process Source: UniProtKB-HAMAP
  2. chorismate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00053; UER00088.

Names & Taxonomyi

Protein namesi
Recommended name:
Shikimate kinaseUniRule annotation (EC:2.7.1.71UniRule annotation)
Short name:
SKUniRule annotation
Gene namesi
Name:aroKUniRule annotation
Ordered Locus Names:ML0517
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML0517.

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 199199Shikimate kinasePRO_0000192392Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi272631.ML0517.

Structurei

3D structure databases

ProteinModelPortaliQ9CCS5.
SMRiQ9CCS5. Positions 2-167.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the shikimate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0703.
HOGENOMiHOG000032568.
KOiK00891.
OMAiADIPWIF.
OrthoDBiEOG6SJJGD.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00109. Shikimate_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR000623. Shikimate_kinase/TSH1.
IPR023000. Shikimate_kinase_CS.
[Graphical view]
PfamiPF01202. SKI. 1 hit.
[Graphical view]
PRINTSiPR01100. SHIKIMTKNASE.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS01128. SHIKIMATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CCS5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPKAVLVGL PGAGKSTIGR RLSKALGVSL LDTDAAIEKQ TGRSIADIFA
60 70 80 90 100
IDGEEEFRRI EEGVVRAALV EHDGVVSLGG GAVTSPGVCA ALAGHIVIYL
110 120 130 140 150
EINAEEAMRR ACGSTVRPLL AGPDRAEKFQ DLMARRVPLY RRVATIRVDT
160 170 180 190
NCHNLGAVVR YIMARLQAQL ATPVSGGDRK SSEAERSGAP LRKSSEVVK
Length:199
Mass (Da):21,084
Last modified:June 1, 2001 - v1
Checksum:iFCA4D829CB520477
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583918 Genomic DNA. Translation: CAC30025.1.
PIRiE86973.
RefSeqiNP_301442.1. NC_002677.1.
WP_010907766.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30025; CAC30025; CAC30025.
GeneIDi909274.
KEGGimle:ML0517.
PATRICi18051918. VBIMycLep78757_0906.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583918 Genomic DNA. Translation: CAC30025.1 .
PIRi E86973.
RefSeqi NP_301442.1. NC_002677.1.
WP_010907766.1. NC_002677.1.

3D structure databases

ProteinModelPortali Q9CCS5.
SMRi Q9CCS5. Positions 2-167.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272631.ML0517.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC30025 ; CAC30025 ; CAC30025 .
GeneIDi 909274.
KEGGi mle:ML0517.
PATRICi 18051918. VBIMycLep78757_0906.

Organism-specific databases

Lepromai ML0517.

Phylogenomic databases

eggNOGi COG0703.
HOGENOMi HOG000032568.
KOi K00891.
OMAi ADIPWIF.
OrthoDBi EOG6SJJGD.

Enzyme and pathway databases

UniPathwayi UPA00053 ; UER00088 .

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00109. Shikimate_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR000623. Shikimate_kinase/TSH1.
IPR023000. Shikimate_kinase_CS.
[Graphical view ]
Pfami PF01202. SKI. 1 hit.
[Graphical view ]
PRINTSi PR01100. SHIKIMTKNASE.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS01128. SHIKIMATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiAROK_MYCLE
AccessioniPrimary (citable) accession number: Q9CCS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 1, 2001
Last modified: November 26, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3