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Q9CCS5 (AROK_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Shikimate kinase

Short name=SK
EC=2.7.1.71
Gene names
Name:aroK
Ordered Locus Names:ML0517
OrganismMycobacterium leprae (strain TN) [Complete proteome] [HAMAP]
Taxonomic identifier272631 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length199 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate By similarity. HAMAP-Rule MF_00109

Catalytic activity

ATP + shikimate = ADP + shikimate 3-phosphate. HAMAP-Rule MF_00109

Cofactor

Binds 1 magnesium ion per subunit By similarity. HAMAP-Rule MF_00109

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7. HAMAP-Rule MF_00109

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00109

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00109.

Sequence similarities

Belongs to the shikimate kinase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Magnesium
Metal-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

chorismate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

magnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

shikimate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 199199Shikimate kinase HAMAP-Rule MF_00109
PRO_0000192392

Regions

Nucleotide binding12 – 176ATP By similarity

Sites

Metal binding161Magnesium By similarity
Binding site341Substrate By similarity
Binding site581Substrate By similarity
Binding site801Substrate; via amide nitrogen By similarity
Binding site1171ATP By similarity
Binding site1361Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9CCS5 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: FCA4D829CB520477

FASTA19921,084
        10         20         30         40         50         60 
MAPKAVLVGL PGAGKSTIGR RLSKALGVSL LDTDAAIEKQ TGRSIADIFA IDGEEEFRRI 

        70         80         90        100        110        120 
EEGVVRAALV EHDGVVSLGG GAVTSPGVCA ALAGHIVIYL EINAEEAMRR ACGSTVRPLL 

       130        140        150        160        170        180 
AGPDRAEKFQ DLMARRVPLY RRVATIRVDT NCHNLGAVVR YIMARLQAQL ATPVSGGDRK 

       190 
SSEAERSGAP LRKSSEVVK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL583918 Genomic DNA. Translation: CAC30025.1.
PIRE86973.
RefSeqNP_301442.1. NC_002677.1.

3D structure databases

ProteinModelPortalQ9CCS5.
SMRQ9CCS5. Positions 2-167.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272631.ML0517.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC30025; CAC30025; CAC30025.
GeneID909274.
KEGGmle:ML0517.
PATRIC18051918. VBIMycLep78757_0906.

Organism-specific databases

LepromaML0517.
CMRSearch...

Phylogenomic databases

eggNOGCOG0703.
HOGENOMHOG000032568.
KOK00891.
OMAADIPWIF.
OrthoDBEOG6SJJGD.
ProtClustDBPRK00131.

Enzyme and pathway databases

UniPathwayUPA00053; UER00088.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
HAMAPMF_00109. Shikimate_kinase.
InterProIPR027417. P-loop_NTPase.
IPR000623. Shikimate_kinase/TSH1.
IPR023000. Shikimate_kinase_CS.
[Graphical view]
PfamPF01202. SKI. 1 hit.
[Graphical view]
PRINTSPR01100. SHIKIMTKNASE.
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS01128. SHIKIMATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROK_MYCLE
AccessionPrimary (citable) accession number: Q9CCS5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways