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Q9CCS5

- AROK_MYCLE

UniProt

Q9CCS5 - AROK_MYCLE

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Protein
Shikimate kinase
Gene
aroK, ML0517
Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate By similarity.UniRule annotation

Catalytic activityi

ATP + shikimate = ADP + shikimate 3-phosphate.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi16 – 161Magnesium By similarity
Binding sitei34 – 341Substrate By similarity
Binding sitei58 – 581Substrate By similarity
Binding sitei80 – 801Substrate; via amide nitrogen By similarity
Binding sitei117 – 1171ATP By similarity
Binding sitei136 – 1361Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 176ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. shikimate kinase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. aromatic amino acid family biosynthetic process Source: UniProtKB-HAMAP
  2. chorismate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00053; UER00088.

Names & Taxonomyi

Protein namesi
Recommended name:
Shikimate kinase (EC:2.7.1.71)
Short name:
SK
Gene namesi
Name:aroK
Ordered Locus Names:ML0517
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML0517.

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 199199Shikimate kinaseUniRule annotation
PRO_0000192392Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi272631.ML0517.

Structurei

3D structure databases

ProteinModelPortaliQ9CCS5.
SMRiQ9CCS5. Positions 2-167.

Family & Domainsi

Sequence similaritiesi

Belongs to the shikimate kinase family.

Phylogenomic databases

eggNOGiCOG0703.
HOGENOMiHOG000032568.
KOiK00891.
OMAiADIPWIF.
OrthoDBiEOG6SJJGD.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00109. Shikimate_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR000623. Shikimate_kinase/TSH1.
IPR023000. Shikimate_kinase_CS.
[Graphical view]
PfamiPF01202. SKI. 1 hit.
[Graphical view]
PRINTSiPR01100. SHIKIMTKNASE.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS01128. SHIKIMATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CCS5-1 [UniParc]FASTAAdd to Basket

« Hide

MAPKAVLVGL PGAGKSTIGR RLSKALGVSL LDTDAAIEKQ TGRSIADIFA    50
IDGEEEFRRI EEGVVRAALV EHDGVVSLGG GAVTSPGVCA ALAGHIVIYL 100
EINAEEAMRR ACGSTVRPLL AGPDRAEKFQ DLMARRVPLY RRVATIRVDT 150
NCHNLGAVVR YIMARLQAQL ATPVSGGDRK SSEAERSGAP LRKSSEVVK 199
Length:199
Mass (Da):21,084
Last modified:June 1, 2001 - v1
Checksum:iFCA4D829CB520477
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL583918 Genomic DNA. Translation: CAC30025.1.
PIRiE86973.
RefSeqiNP_301442.1. NC_002677.1.
WP_010907766.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30025; CAC30025; CAC30025.
GeneIDi909274.
KEGGimle:ML0517.
PATRICi18051918. VBIMycLep78757_0906.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL583918 Genomic DNA. Translation: CAC30025.1 .
PIRi E86973.
RefSeqi NP_301442.1. NC_002677.1.
WP_010907766.1. NC_002677.1.

3D structure databases

ProteinModelPortali Q9CCS5.
SMRi Q9CCS5. Positions 2-167.
ModBasei Search...

Protein-protein interaction databases

STRINGi 272631.ML0517.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC30025 ; CAC30025 ; CAC30025 .
GeneIDi 909274.
KEGGi mle:ML0517.
PATRICi 18051918. VBIMycLep78757_0906.

Organism-specific databases

Lepromai ML0517.

Phylogenomic databases

eggNOGi COG0703.
HOGENOMi HOG000032568.
KOi K00891.
OMAi ADIPWIF.
OrthoDBi EOG6SJJGD.

Enzyme and pathway databases

UniPathwayi UPA00053 ; UER00088 .

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00109. Shikimate_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR000623. Shikimate_kinase/TSH1.
IPR023000. Shikimate_kinase_CS.
[Graphical view ]
Pfami PF01202. SKI. 1 hit.
[Graphical view ]
PRINTSi PR01100. SHIKIMTKNASE.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS01128. SHIKIMATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiAROK_MYCLE
AccessioniPrimary (citable) accession number: Q9CCS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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