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Protein

3-dehydroquinate synthase

Gene

aroB

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).UniRule annotation

Catalytic activityi

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • NAD+UniRule annotation
  • Co2+UniRule annotation, Zn2+UniRule annotationNote: Binds 1 divalent metal cation per subunit. Can use either Co2+ or Zn2+.UniRule annotation

Pathwayi: chorismate biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. Phospho-2-dehydro-3-deoxyheptonate aldolase (aroG)
  2. 3-dehydroquinate synthase (aroB)
  3. 3-dehydroquinate dehydratase (aroQ)
  4. no protein annotated in this organism
  5. Shikimate kinase (aroK)
  6. 3-phosphoshikimate 1-carboxyvinyltransferase (aroA)
  7. Chorismate synthase (aroC)
This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate, the pathway chorismate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei144NAD; via carbonyl oxygenUniRule annotation1
Binding sitei153NADUniRule annotation1
Metal bindingi186Cobalt or zincUniRule annotation1
Metal bindingi249Cobalt or zinc; via tele nitrogenUniRule annotation1
Metal bindingi265Cobalt or zinc; via tele nitrogenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi73 – 78NADUniRule annotation6
Nucleotide bindingi107 – 111NADUniRule annotation5
Nucleotide bindingi131 – 132NADUniRule annotation2
Nucleotide bindingi171 – 174NADUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis
LigandCobalt, Metal-binding, NAD, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciMLEP272631:G1GT5-570-MONOMER
UniPathwayiUPA00053; UER00085

Names & Taxonomyi

Protein namesi
Recommended name:
3-dehydroquinate synthaseUniRule annotation (EC:4.2.3.4UniRule annotation)
Short name:
DHQSUniRule annotation
Gene namesi
Name:aroBUniRule annotation
Ordered Locus Names:ML0518
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0518

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001407561 – 3613-dehydroquinate synthaseAdd BLAST361

Interactioni

Protein-protein interaction databases

STRINGi272631.ML0518

Structurei

3D structure databases

ProteinModelPortaliQ9CCS4
SMRiQ9CCS4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.UniRule annotationCurated

Phylogenomic databases

eggNOGiENOG4105D49 Bacteria
COG0337 LUCA
HOGENOMiHOG000007970
KOiK01735
OMAiCGFIADP
OrthoDBiPOG091H0125

Family and domain databases

HAMAPiMF_00110 DHQ_synthase, 1 hit
InterProiView protein in InterPro
IPR016037 DHQ_synth_AroB
IPR030963 DHQ_synth_fam
IPR030960 DHQS/DOIS
PfamiView protein in Pfam
PF01761 DHQ_synthase, 1 hit
PIRSFiPIRSF001455 DHQ_synth, 1 hit
TIGRFAMsiTIGR01357 aroB, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CCS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNIDAPVTV QVAVDPPYPV VIGTGLSDQL DELLANRHRV AILHQPVLTQ
60 70 80 90 100
TAEAIRSHLA GKGVDAHRIE IPDAEAGKDL SVMDFIWEVL GRIGIGRKDA
110 120 130 140 150
LVSFGGGAAT DVAGFAAATW LRGVSIVHVP TTLLGMVDAA VGGKTGINTE
160 170 180 190 200
AGKNLVGAFH QPLAVLADLA TLETLPRKEI ASGMAEVVKA GFIADPIILD
210 220 230 240 250
LIEADPQASL DPMGGVLPEL IRRAVTVKAG VVSADEKESE LREILNYGHT
260 270 280 290 300
LAHAIERRER YEWRHGAAVS VGLVFAAELA RVAGRLDDAT AQRHHTILTS
310 320 330 340 350
LGLPVSYDAD ALPQLLEYMA GDKKTRAGVL RFVILDGLAK PGRLVGPDPG
360
LLVTAYAGLS A
Length:361
Mass (Da):38,032
Last modified:April 27, 2001 - v1
Checksum:i3963619299D31CA2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583918 Genomic DNA Translation: CAC30026.1
PIRiF86973
RefSeqiNP_301443.1, NC_002677.1
WP_010907767.1, NC_002677.1

Genome annotation databases

EnsemblBacteriaiCAC30026; CAC30026; CAC30026
GeneIDi909275
KEGGimle:ML0518
PATRICifig|272631.5.peg.907

Similar proteinsi

Entry informationi

Entry nameiAROB_MYCLE
AccessioniPrimary (citable) accession number: Q9CCS4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: February 28, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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