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Protein

3-dehydroquinate synthase

Gene

aroB

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate.

Cofactori

Protein has several cofactor binding sites:
  • NAD+By similarity
  • Co2+By similarity, Zn2+By similarityNote: Binds 1 divalent metal cation per subunit. Can use either Co2+ or Zn2+.By similarity

Pathwayi: chorismate biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate.
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. Phospho-2-dehydro-3-deoxyheptonate aldolase (aroG)
  2. 3-dehydroquinate synthase (aroB)
  3. 3-dehydroquinate dehydratase (aroQ)
  4. no protein annotated in this organism
  5. Shikimate kinase (aroK)
  6. 3-phosphoshikimate 1-carboxyvinyltransferase (aroA)
  7. Chorismate synthase (aroC)
This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate, the pathway chorismate biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis

Keywords - Ligandi

Cobalt, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00053; UER00085.

Names & Taxonomyi

Protein namesi
Recommended name:
3-dehydroquinate synthase (EC:4.2.3.4)
Gene namesi
Name:aroB
Ordered Locus Names:ML0518
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0518.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3613613-dehydroquinate synthasePRO_0000140756Add
BLAST

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi272631.ML0518.

Structurei

3D structure databases

ProteinModelPortaliQ9CCS4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dehydroquinate synthase family.Curated

Phylogenomic databases

eggNOGiENOG4105D49. Bacteria.
COG0337. LUCA.
HOGENOMiHOG000007970.
KOiK01735.
OMAiIERSCAA.
OrthoDBiEOG6SJJGD.

Family and domain databases

HAMAPiMF_00110. DHQ_synthase.
InterProiIPR016037. DHQ_synth_AroB.
IPR030963. DHQ_synth_fam.
IPR030960. DHQS/DOIS.
[Graphical view]
PfamiPF01761. DHQ_synthase. 1 hit.
[Graphical view]
PIRSFiPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsiTIGR01357. aroB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CCS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNIDAPVTV QVAVDPPYPV VIGTGLSDQL DELLANRHRV AILHQPVLTQ
60 70 80 90 100
TAEAIRSHLA GKGVDAHRIE IPDAEAGKDL SVMDFIWEVL GRIGIGRKDA
110 120 130 140 150
LVSFGGGAAT DVAGFAAATW LRGVSIVHVP TTLLGMVDAA VGGKTGINTE
160 170 180 190 200
AGKNLVGAFH QPLAVLADLA TLETLPRKEI ASGMAEVVKA GFIADPIILD
210 220 230 240 250
LIEADPQASL DPMGGVLPEL IRRAVTVKAG VVSADEKESE LREILNYGHT
260 270 280 290 300
LAHAIERRER YEWRHGAAVS VGLVFAAELA RVAGRLDDAT AQRHHTILTS
310 320 330 340 350
LGLPVSYDAD ALPQLLEYMA GDKKTRAGVL RFVILDGLAK PGRLVGPDPG
360
LLVTAYAGLS A
Length:361
Mass (Da):38,032
Last modified:April 27, 2001 - v1
Checksum:i3963619299D31CA2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583918 Genomic DNA. Translation: CAC30026.1.
PIRiF86973.
RefSeqiNP_301443.1. NC_002677.1.
WP_010907767.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30026; CAC30026; CAC30026.
GeneIDi909275.
KEGGimle:ML0518.
PATRICi18051920. VBIMycLep78757_0907.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583918 Genomic DNA. Translation: CAC30026.1.
PIRiF86973.
RefSeqiNP_301443.1. NC_002677.1.
WP_010907767.1. NC_002677.1.

3D structure databases

ProteinModelPortaliQ9CCS4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML0518.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC30026; CAC30026; CAC30026.
GeneIDi909275.
KEGGimle:ML0518.
PATRICi18051920. VBIMycLep78757_0907.

Organism-specific databases

LepromaiML0518.

Phylogenomic databases

eggNOGiENOG4105D49. Bacteria.
COG0337. LUCA.
HOGENOMiHOG000007970.
KOiK01735.
OMAiIERSCAA.
OrthoDBiEOG6SJJGD.

Enzyme and pathway databases

UniPathwayiUPA00053; UER00085.

Family and domain databases

HAMAPiMF_00110. DHQ_synthase.
InterProiIPR016037. DHQ_synth_AroB.
IPR030963. DHQ_synth_fam.
IPR030960. DHQS/DOIS.
[Graphical view]
PfamiPF01761. DHQ_synthase. 1 hit.
[Graphical view]
PIRSFiPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsiTIGR01357. aroB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiAROB_MYCLE
AccessioniPrimary (citable) accession number: Q9CCS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: November 11, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.