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Q9CCS4 (AROB_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:ML0518
OrganismMycobacterium leprae [Complete proteome] [HAMAP]
Taxonomic identifier1769 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length361 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

NAD By similarity. HAMAP MF_00110

Divalent metal cations By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm Probable HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3613613-dehydroquinate synthase HAMAP MF_00110
PRO_0000140756

Sequences

Sequence LengthMass (Da)Tools
Q9CCS4 [UniParc].

Last modified April 27, 2001. Version 1.
Checksum: 3963619299D31CA2

FASTA36138,032
        10         20         30         40         50         60 
MTNIDAPVTV QVAVDPPYPV VIGTGLSDQL DELLANRHRV AILHQPVLTQ TAEAIRSHLA 

        70         80         90        100        110        120 
GKGVDAHRIE IPDAEAGKDL SVMDFIWEVL GRIGIGRKDA LVSFGGGAAT DVAGFAAATW 

       130        140        150        160        170        180 
LRGVSIVHVP TTLLGMVDAA VGGKTGINTE AGKNLVGAFH QPLAVLADLA TLETLPRKEI 

       190        200        210        220        230        240 
ASGMAEVVKA GFIADPIILD LIEADPQASL DPMGGVLPEL IRRAVTVKAG VVSADEKESE 

       250        260        270        280        290        300 
LREILNYGHT LAHAIERRER YEWRHGAAVS VGLVFAAELA RVAGRLDDAT AQRHHTILTS 

       310        320        330        340        350        360 
LGLPVSYDAD ALPQLLEYMA GDKKTRAGVL RFVILDGLAK PGRLVGPDPG LLVTAYAGLS 


A

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL583918 Genomic DNA. Translation: CAC30026.1.
PIRF86973.
RefSeqNP_301443.1. NC_002677.1.

3D structure databases

ProteinModelPortalQ9CCS4.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000029116; EBMYCP00000028722; EBMYCG00000029111.
GeneID909275.
GenomeReviewsGene locus ML0518 in contig AL450380_GR.
KEGGmle:ML0518.
NMPDRfig|272631.1.peg.315.
PATRIC18051920. VBIMycLep78757_0907.

Organism-specific databases

LepromaML0518.
CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000016995.
HOGENOMHBG632303.
OMAWMRGVRV.
ProtClustDBPRK00002.

Enzyme and pathway databases

BioCycMLEP272631:ML0518-MONOMER.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_MYCLE
AccessionPrimary (citable) accession number: Q9CCS4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: January 25, 2012
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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