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Q9CCR1

- PYRF_MYCLE

UniProt

Q9CCR1 - PYRF_MYCLE

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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei95 – 951Proton donorBy similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Ordered Locus Names:ML0537
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML0537.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 282282Orotidine 5'-phosphate decarboxylasePRO_0000134628Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272631.ML0537.

Structurei

3D structure databases

ProteinModelPortaliQ9CCR1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000245748.
KOiK01591.
OMAiGSTMGAY.
OrthoDBiEOG6DZF33.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01215. OMPdecase_type2.
InterProiIPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR02127. pyrF_sub2. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CCR1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTGFGARLVE ATSRRGQLCL GIDPHPELLR AWDLPTTADG LAAFCDICVE
60 70 80 90 100
AFSGFAIVKP QVAFFEAYGA AGFAVLEYTI AALRSVGVLV LADAKRGDIG
110 120 130 140 150
STMAAYAAAW AGNSPLAADA VTASPYLGFG SLRPLLEVAA AHDRGVFVLA
160 170 180 190 200
STSNLEGATV QRATFDGRIV AQLIVDQAAF VNREMNRSFH RSEPGCLGYV
210 220 230 240 250
GVVVGATVFG APDVSALGGP VLVPGVGAQG GHPEALGGLG GAAPGQLLPA
260 270 280
VSRAVLRAGP GVSELRAAGE QMRDAVAYLA AV
Length:282
Mass (Da):28,678
Last modified:June 1, 2001 - v1
Checksum:i89DE23C44B227BA5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL583918 Genomic DNA. Translation: CAC30045.1.
PIRiA86976.
RefSeqiNP_301456.1. NC_002677.1.
WP_010907780.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30045; CAC30045; CAC30045.
GeneIDi909117.
KEGGimle:ML0537.
PATRICi18051982. VBIMycLep78757_0938.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL583918 Genomic DNA. Translation: CAC30045.1 .
PIRi A86976.
RefSeqi NP_301456.1. NC_002677.1.
WP_010907780.1. NC_002677.1.

3D structure databases

ProteinModelPortali Q9CCR1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272631.ML0537.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC30045 ; CAC30045 ; CAC30045 .
GeneIDi 909117.
KEGGi mle:ML0537.
PATRICi 18051982. VBIMycLep78757_0938.

Organism-specific databases

Lepromai ML0537.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000245748.
KOi K01591.
OMAi GSTMGAY.
OrthoDBi EOG6DZF33.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01215. OMPdecase_type2.
InterProi IPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR02127. pyrF_sub2. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiPYRF_MYCLE
AccessioniPrimary (citable) accession number: Q9CCR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 1, 2001
Last modified: October 1, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3