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Protein

Guanylate kinase

Gene

gmk

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential for recycling GMP and indirectly, cGMP.By similarity

Catalytic activityi

ATP + GMP = ADP + GDP.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi30 – 37ATPBy similarity8

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMLEP272631:G1GT5-593-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinase (EC:2.7.4.8)
Alternative name(s):
GMP kinase
Gene namesi
Name:gmk
Ordered Locus Names:ML0541
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0541

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001705641 – 210Guanylate kinaseAdd BLAST210

Interactioni

Protein-protein interaction databases

STRINGi272631.ML0541

Structurei

3D structure databases

ProteinModelPortaliQ9CCQ7
SMRiQ9CCQ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 203Guanylate kinase-likeAdd BLAST181

Sequence similaritiesi

Belongs to the guanylate kinase family.Curated

Phylogenomic databases

eggNOGiENOG4108UHA Bacteria
COG0194 LUCA
HOGENOMiHOG000037640
KOiK00942
OMAiAGNYYGT
OrthoDBiPOG091H01Q4

Family and domain databases

HAMAPiMF_00328 Guanylate_kinase, 1 hit
InterProiView protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR017665 Guanylate_kinase
IPR020590 Guanylate_kinase_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR03263 guanyl_kin, 1 hit
PROSITEiView protein in PROSITE
PS00856 GUANYLATE_KINASE_1, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CCQ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVSARGAPD AEHWAWSEQT DKGRVVVLSG PSAVGKSTVV RCLRERVSNL
60 70 80 90 100
HFSVSATTRE PRPDEMDGVD YHFVSPARFQ QLIDQGALLE WAEIHGGMHR
110 120 130 140 150
SGTLAEPVRV AAAAGFPVLI EVDLAGARAV KKAMPEAIAV FLAPPSWEDL
160 170 180 190 200
EARLVGRGTE TPEAIRRRLE TARIELAAQD DFDEVVVNRR LESACAELVS
210
LLVGAVSGSA
Length:210
Mass (Da):22,658
Last modified:June 1, 2001 - v1
Checksum:i51E1E72E5141E19B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583918 Genomic DNA Translation: CAC30049.1
PIRiE86976
RefSeqiNP_301460.1, NC_002677.1
WP_010907784.1, NC_002677.1

Genome annotation databases

EnsemblBacteriaiCAC30049; CAC30049; CAC30049
GeneIDi909307
KEGGimle:ML0541
PATRICifig|272631.5.peg.942

Similar proteinsi

Entry informationi

Entry nameiKGUA_MYCLE
AccessioniPrimary (citable) accession number: Q9CCQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health