Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ribulose-phosphate 3-epimerase

Gene

rpe

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.By similarity

Catalytic activityi

D-ribulose 5-phosphate = D-xylulose 5-phosphate.

Cofactori

Co2+By similarity, Fe2+By similarity, Mn2+By similarity, Zn2+By similarityNote: Binds 1 divalent metal cation per subunit. Active with Co2+, Fe2+, Mn2+ and Zn2+.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei8SubstrateBy similarity1
Metal bindingi31Divalent metal cationBy similarity1
Active sitei33Proton acceptorBy similarity1
Metal bindingi33Divalent metal cationBy similarity1
Metal bindingi64Divalent metal cationBy similarity1
Binding sitei64SubstrateBy similarity1
Active sitei173Proton donorBy similarity1
Metal bindingi173Divalent metal cationBy similarity1
Binding sitei175Substrate; via amide nitrogenBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

Cobalt, Iron, Manganese, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose-phosphate 3-epimerase (EC:5.1.3.1)
Alternative name(s):
Pentose-5-phosphate 3-epimerase
Short name:
PPE
R5P3E
Gene namesi
Name:rpe
Ordered Locus Names:ML0554
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0554.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001715761 – 224Ribulose-phosphate 3-epimeraseAdd BLAST224

Interactioni

Protein-protein interaction databases

STRINGi272631.ML0554.

Structurei

3D structure databases

ProteinModelPortaliQ9CCP9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni140 – 143Substrate bindingBy similarity4
Regioni195 – 196Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105DJV. Bacteria.
COG0036. LUCA.
HOGENOMiHOG000259349.
KOiK01783.
OMAiHYEACTH.
OrthoDBiPOG091H01TC.

Family and domain databases

CDDicd00429. RPE. 1 hit.
Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR026019. Ribul_P_3_epim.
IPR000056. Ribul_P_3_epim-like.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PANTHERiPTHR11749. PTHR11749. 1 hit.
PfamiPF00834. Ribul_P_3_epim. 1 hit.
[Graphical view]
PIRSFiPIRSF001461. RPE. 1 hit.
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01163. rpe. 1 hit.
PROSITEiPS01085. RIBUL_P_3_EPIMER_1. 1 hit.
PS01086. RIBUL_P_3_EPIMER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CCP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPLIAPSIL AADFARLTDE AAVVASADWL HVDVMDGHFV PNLTIGLPVV
60 70 80 90 100
QSLLAASDIP MDCHLMIDNP DRWAPPYAEA GAYNVTFHAE ATDNPVGVAH
110 120 130 140 150
DIRTAGAKAG IGVKPGTPLN PYLDILPHFD TLLIMSVEPG FGGQAFIPEV
160 170 180 190 200
LSKVRTVRKM VDAGELTILV EIDGGINADT IEQAAEAGVD CFVAGSAVYG
210 220
AADPSAAVAA LRRRAGAVSP HLRR
Length:224
Mass (Da):23,408
Last modified:June 1, 2001 - v1
Checksum:iECD520C9D6666B59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583918 Genomic DNA. Translation: CAC30062.1.
PIRiB86978.
RefSeqiNP_301468.1. NC_002677.1.
WP_010907792.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30062; CAC30062; CAC30062.
GeneIDi909330.
KEGGimle:ML0554.
PATRICi18052036. VBIMycLep78757_0965.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583918 Genomic DNA. Translation: CAC30062.1.
PIRiB86978.
RefSeqiNP_301468.1. NC_002677.1.
WP_010907792.1. NC_002677.1.

3D structure databases

ProteinModelPortaliQ9CCP9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML0554.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC30062; CAC30062; CAC30062.
GeneIDi909330.
KEGGimle:ML0554.
PATRICi18052036. VBIMycLep78757_0965.

Organism-specific databases

LepromaiML0554.

Phylogenomic databases

eggNOGiENOG4105DJV. Bacteria.
COG0036. LUCA.
HOGENOMiHOG000259349.
KOiK01783.
OMAiHYEACTH.
OrthoDBiPOG091H01TC.

Family and domain databases

CDDicd00429. RPE. 1 hit.
Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR026019. Ribul_P_3_epim.
IPR000056. Ribul_P_3_epim-like.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PANTHERiPTHR11749. PTHR11749. 1 hit.
PfamiPF00834. Ribul_P_3_epim. 1 hit.
[Graphical view]
PIRSFiPIRSF001461. RPE. 1 hit.
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01163. rpe. 1 hit.
PROSITEiPS01085. RIBUL_P_3_EPIMER_1. 1 hit.
PS01086. RIBUL_P_3_EPIMER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRPE_MYCLE
AccessioniPrimary (citable) accession number: Q9CCP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.