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Q9CCP3 (RISB_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6,7-dimethyl-8-ribityllumazine synthase
Short name=DMRL synthase
Short name=Lumazine synthase
EC=2.5.1.9
Alternative name(s):
Riboflavin synthase beta chain
Gene names
Name:ribH
Ordered Locus Names:ML0560
OrganismMycobacterium leprae [Complete proteome] [HAMAP]
Taxonomic identifier1769 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length160 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2-butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The beta subunit catalyzes the condensation of 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate yielding 6,7-dimethyl-8-lumazine By similarity. HAMAP MF_00178

Catalytic activity

2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine. HAMAP MF_00178

Pathway

Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2. HAMAP MF_00178

Sequence similarities

Belongs to the DMRL synthase family.

Ontologies

Keywords
   Biological processRiboflavin biosynthesis
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processriboflavin biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentriboflavin synthase complex

Inferred from electronic annotation. Source: InterPro

   Molecular functionriboflavin synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 1601606,7-dimethyl-8-ribityllumazine synthase HAMAP MF_00178
PRO_0000134770

Regions

Compositional bias140 – 1467Poly-Ala HAMAP MF_00178

Sequences

Sequence LengthMass (Da)Tools
Q9CCP3 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: EB4A8BDEDB8B026C

FASTA16016,337
        10         20         30         40         50         60 
MSGGAGIPEV PGIDASGLRL GIVASTWHSR ICDALLAGAR KVAADSGIDG PTVVRVLGAI 

        70         80         90        100        110        120 
EIPVVVQELA RHHDAVVALG VVIRGDTPHF DYVCNSVTQG LTRIALDTST PVGNGVLTTN 

       130        140        150        160 
TEKQALDRAG LPTSAEDKGA QAAAAALTTA LTLLNLRSRI

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL583918 Genomic DNA. Translation: CAC30068.1.
PIRH86978.
RefSeqNP_301474.1. NC_002677.1.

3D structure databases

ProteinModelPortalQ9CCP3.
SMRQ9CCP3. Positions 10-158.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000028337; EBMYCP00000027943; EBMYCG00000028332.
GeneID909339.
GenomeReviewsGene locus ML0560 in contig AL450380_GR.
KEGGmle:ML0560.
NMPDRfig|272631.1.peg.346.
PATRIC18052048. VBIMycLep78757_0971.

Organism-specific databases

LepromaML0560.
CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000016935.
HOGENOMHBG311126.
OMASSRALMD.
ProtClustDBPRK00061.

Enzyme and pathway databases

BioCycMLEP272631:ML0560-MONOMER.

Family and domain databases

HAMAPMF_00178. Lumazine_synth.
[Tree]
InterProIPR002180. DMRL_synthase.
[Graphical view]
Gene3DG3DSA:3.40.50.960. DMRL_synthase. 1 hit.
KOK00794.
PANTHERPTHR21058. DMRL_synthase. 1 hit.
PfamPF00885. DMRL_synthase. 1 hit.
[Graphical view]
SUPFAMSSF52121. DMRL_synthase. 1 hit.
TIGRFAMsTIGR00114. Lumazine-synth. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRISB_MYCLE
AccessionPrimary (citable) accession number: Q9CCP3
Entry history
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: June 1, 2001
Last modified: January 25, 2012
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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