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Protein

UvrABC system protein C

Gene

uvrC

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExcision nuclease
Biological processDNA damage, DNA excision, DNA repair, SOS response

Enzyme and pathway databases

BioCyciMLEP272631:G1GT5-614-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein CUniRule annotation
Short name:
Protein UvrCUniRule annotation
Alternative name(s):
Excinuclease ABC subunit CUniRule annotation
Gene namesi
Name:uvrCUniRule annotation
Ordered Locus Names:ML0562
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0562

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001383191 – 647UvrABC system protein CAdd BLAST647

Interactioni

Subunit structurei

Interacts with UvrB in an incision complex.UniRule annotation

Protein-protein interaction databases

STRINGi272631.ML0562

Structurei

3D structure databases

ProteinModelPortaliQ9CCP1
SMRiQ9CCP1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 95GIY-YIGUniRule annotationAdd BLAST80
Domaini208 – 243UVRUniRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the UvrC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CII Bacteria
COG0322 LUCA
HOGENOMiHOG000279962
KOiK03703
OMAiLFPIRQC
OrthoDBiPOG091H01BS

Family and domain databases

Gene3Di3.30.420.340, 1 hit
3.40.1440.10, 1 hit
HAMAPiMF_00203 UvrC, 1 hit
InterProiView protein in InterPro
IPR000305 GIY-YIG_endonuc
IPR035901 GIY-YIG_endonuc_sf
IPR003583 Hlx-hairpin-Hlx_DNA-bd_motif
IPR010994 RuvA_2-like
IPR001943 UVR_dom
IPR036876 UVR_dom_sf
IPR004791 UvrC
IPR001162 UvrC_homol_region
IPR038476 UvrC_homol_region_sf
PfamiView protein in Pfam
PF01541 GIY-YIG, 1 hit
PF02151 UVR, 1 hit
PF08459 UvrC_HhH_N, 1 hit
SMARTiView protein in SMART
SM00465 GIYc, 1 hit
SM00278 HhH1, 2 hits
SUPFAMiSSF46600 SSF46600, 1 hit
SSF47781 SSF47781, 1 hit
SSF82771 SSF82771, 1 hit
TIGRFAMsiTIGR00194 uvrC, 1 hit
PROSITEiView protein in PROSITE
PS50164 GIY_YIG, 1 hit
PS50151 UVR, 1 hit
PS50165 UVRC, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CCP1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDPATYRPA TGSIPVEPGV YRFRDPYGRV IYVGKAKSLR SRLASYFADV
60 70 80 90 100
ANLHPRTRQM VTIAAKVEWT VVNTEVEALQ LEYNWIKEFD PRFNIRYRDD
110 120 130 140 150
KSYPVLAVTL GEEFPRLMVY RGPRRKGVRY FGPYSHAWAI RETLDLLTRV
160 170 180 190 200
FPARTCSPGV FKRHKQIDRP CLLGYIDKCA APCVGRVGAE QHSQIVADFC
210 220 230 240 250
DFLSGKTDRY ARDLERKMSA AAEQLDFERA ARLRDDLFAL KRAMEKQAVV
260 270 280 290 300
FGDGTDADVV AFAYDELEVA VQVFHVRGGR VRGQRGWIVE KSDDPGDTGE
310 320 330 340 350
EQLVEQFLAQ FYGEQAELDF VADESANPVP REVLVPCLPS NADELASWLS
360 370 380 390 400
GLRGSRVALR VPRRGDKRAL AETVQRNAKE ELQQHKLKRA SDFNSRSAAL
410 420 430 440 450
QNIQDTLGLS YAPLRIECVD ISHVQGTDVV GSLVVFEDGL PRKSDYRHFG
460 470 480 490 500
IRKAAGNGRS DDVASIAEVT RRRFLQHLHD QNDTNLLSPE GKSHRFAYPP
510 520 530 540 550
NLYVVDGGAP QVNAASTVLE ELGIIDVAVI GLAKRLEEVW VPFEPYPVIM
560 570 580 590 600
PRNSEALFLL QRVRDEAHRF AITYHRSKRS KRMTASALDS VPGLGAHRRK
610 620 630 640
ALVTHFGSIA RLKDATVEQI TAVPGIGVAT ATAVLEALRP DSSEASE
Length:647
Mass (Da):72,386
Last modified:June 1, 2001 - v1
Checksum:iBC60CEC8FFC7BAE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583918 Genomic DNA Translation: CAC30070.1
PIRiB86979
RefSeqiNP_301476.1, NC_002677.1
WP_010907800.1, NC_002677.1

Genome annotation databases

EnsemblBacteriaiCAC30070; CAC30070; CAC30070
GeneIDi909343
KEGGimle:ML0562
PATRICifig|272631.5.peg.973

Similar proteinsi

Entry informationi

Entry nameiUVRC_MYCLE
AccessioniPrimary (citable) accession number: Q9CCP1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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