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Protein

UvrABC system protein C

Gene

uvrC

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Excision nuclease

Keywords - Biological processi

DNA damage, DNA excision, DNA repair, SOS response

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein CUniRule annotation
Short name:
Protein UvrCUniRule annotation
Alternative name(s):
Excinuclease ABC subunit CUniRule annotation
Gene namesi
Name:uvrCUniRule annotation
Ordered Locus Names:ML0562
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0562.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 647647UvrABC system protein CPRO_0000138319Add
BLAST

Interactioni

Subunit structurei

Interacts with UvrB in an incision complex.UniRule annotation

Protein-protein interaction databases

STRINGi272631.ML0562.

Structurei

3D structure databases

ProteinModelPortaliQ9CCP1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 9580GIY-YIGUniRule annotationAdd
BLAST
Domaini208 – 24336UVRUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the UvrC family.UniRule annotation
Contains 1 GIY-YIG domain.UniRule annotation
Contains 1 UVR domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CII. Bacteria.
COG0322. LUCA.
HOGENOMiHOG000279962.
KOiK03703.
OMAiRCPGVCQ.
OrthoDBiPOG091H01BS.

Family and domain databases

Gene3Di3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPiMF_00203. UvrC. 1 hit.
InterProiIPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view]
PfamiPF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view]
SMARTiSM00465. GIYc. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsiTIGR00194. uvrC. 1 hit.
PROSITEiPS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CCP1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDPATYRPA TGSIPVEPGV YRFRDPYGRV IYVGKAKSLR SRLASYFADV
60 70 80 90 100
ANLHPRTRQM VTIAAKVEWT VVNTEVEALQ LEYNWIKEFD PRFNIRYRDD
110 120 130 140 150
KSYPVLAVTL GEEFPRLMVY RGPRRKGVRY FGPYSHAWAI RETLDLLTRV
160 170 180 190 200
FPARTCSPGV FKRHKQIDRP CLLGYIDKCA APCVGRVGAE QHSQIVADFC
210 220 230 240 250
DFLSGKTDRY ARDLERKMSA AAEQLDFERA ARLRDDLFAL KRAMEKQAVV
260 270 280 290 300
FGDGTDADVV AFAYDELEVA VQVFHVRGGR VRGQRGWIVE KSDDPGDTGE
310 320 330 340 350
EQLVEQFLAQ FYGEQAELDF VADESANPVP REVLVPCLPS NADELASWLS
360 370 380 390 400
GLRGSRVALR VPRRGDKRAL AETVQRNAKE ELQQHKLKRA SDFNSRSAAL
410 420 430 440 450
QNIQDTLGLS YAPLRIECVD ISHVQGTDVV GSLVVFEDGL PRKSDYRHFG
460 470 480 490 500
IRKAAGNGRS DDVASIAEVT RRRFLQHLHD QNDTNLLSPE GKSHRFAYPP
510 520 530 540 550
NLYVVDGGAP QVNAASTVLE ELGIIDVAVI GLAKRLEEVW VPFEPYPVIM
560 570 580 590 600
PRNSEALFLL QRVRDEAHRF AITYHRSKRS KRMTASALDS VPGLGAHRRK
610 620 630 640
ALVTHFGSIA RLKDATVEQI TAVPGIGVAT ATAVLEALRP DSSEASE
Length:647
Mass (Da):72,386
Last modified:June 1, 2001 - v1
Checksum:iBC60CEC8FFC7BAE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583918 Genomic DNA. Translation: CAC30070.1.
PIRiB86979.
RefSeqiNP_301476.1. NC_002677.1.
WP_010907800.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30070; CAC30070; CAC30070.
GeneIDi909343.
KEGGimle:ML0562.
PATRICi18052052. VBIMycLep78757_0973.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583918 Genomic DNA. Translation: CAC30070.1.
PIRiB86979.
RefSeqiNP_301476.1. NC_002677.1.
WP_010907800.1. NC_002677.1.

3D structure databases

ProteinModelPortaliQ9CCP1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML0562.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC30070; CAC30070; CAC30070.
GeneIDi909343.
KEGGimle:ML0562.
PATRICi18052052. VBIMycLep78757_0973.

Organism-specific databases

LepromaiML0562.

Phylogenomic databases

eggNOGiENOG4105CII. Bacteria.
COG0322. LUCA.
HOGENOMiHOG000279962.
KOiK03703.
OMAiRCPGVCQ.
OrthoDBiPOG091H01BS.

Family and domain databases

Gene3Di3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPiMF_00203. UvrC. 1 hit.
InterProiIPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view]
PfamiPF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view]
SMARTiSM00465. GIYc. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsiTIGR00194. uvrC. 1 hit.
PROSITEiPS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUVRC_MYCLE
AccessioniPrimary (citable) accession number: Q9CCP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.