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Q9CCL9 (ADD_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenosine deaminase
EC=3.5.4.4
Alternative name(s):
Adenosine aminohydrolase
Gene names
Name:add
Ordered Locus Names:ML0700
ORF Names:L308_C2_206
OrganismMycobacterium leprae [Complete proteome] [HAMAP]
Taxonomic identifier1769 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Adenosine + H2O = inosine + NH3. HAMAP MF_00540

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00540

Sequence similarities

Belongs to the adenosine and AMP deaminases family. Adenosine deaminase subfamily.

Sequence caution

The sequence AAA17330.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processNucleotide metabolism
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpurine ribonucleoside monophosphate biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionadenosine deaminase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 362362Adenosine deaminase HAMAP MF_00540
PRO_0000194373

Sites

Active site2111Proton donor By similarity
Metal binding191Zinc; catalytic By similarity
Metal binding211Zinc; catalytic By similarity
Metal binding2081Zinc; catalytic By similarity
Metal binding3001Zinc; catalytic By similarity
Binding site211Substrate By similarity
Binding site231Substrate By similarity
Binding site1811Substrate; via amide nitrogen and carbonyl oxygen By similarity
Site2321Important for catalytic activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9CCL9 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: ED0C43B5C92908F5

FASTA36239,637
        10         20         30         40         50         60 
MNTPLHLENI KQAPKALLHD HLDGGLRPAT VLDIAGQVGY DRLPATDVES LETWFRTASH 

        70         80         90        100        110        120 
SGSLERYLEP FSHTVAVMQT PEALHRVAYE CVEDLAADSV VYAEVRFAPE LHIDEGLSFD 

       130        140        150        160        170        180 
EVLASVLAGF ADGERACAAE GNAITVRCLV TAMRHAAMSR EIAELAIRFR DKGVVGFDIA 

       190        200        210        220        230        240 
GAEAGHPPTR HLDAFEYMRS NNARFTIHAG EAFGLPSIHE AIAFCGADRL GHGVRIVDDI 

       250        260        270        280        290        300 
DVDPGGGIRL GPLASILRDK RIPLELCPSS NLQTGAVASI TEHPFDLLAW ARFRVTVNTD 

       310        320        330        340        350        360 
NRLMSDTSMS LEMHRLVEAF GYGWGDLERF TINAMKSAFI PFDQRLAIID EVIKPRFAVL 


VG

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U00022 Genomic DNA. Translation: AAA17330.1. Different initiation.
AL583919 Genomic DNA. Translation: CAC30209.1.
PIRE86996.
S73031.
RefSeqNP_301559.1. NC_002677.1.

3D structure databases

ProteinModelPortalQ9CCL9.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000028687; EBMYCP00000028293; EBMYCG00000028682.
GeneID910518.
GenomeReviewsGene locus ML0700 in contig AL450380_GR.
KEGGmle:ML0700.
NMPDRfig|272631.1.peg.431.
PATRIC18052626. VBIMycLep78757_1259.

Organism-specific databases

LepromaML0700.
CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000016615.
HOGENOMHBG630382.
OMAPYYMAMN.
ProtClustDBPRK09358.

Enzyme and pathway databases

BioCycMLEP272631:ML0700-MONOMER.

Family and domain databases

HAMAPMF_00540. A_deaminase.
[Tree]
InterProIPR001365. A/AMP_deaminase_dom.
IPR006330. A_deaminase.
[Graphical view]
KOK01488.
PANTHERPTHR11409:SF21. PTHR11409:SF21. 1 hit.
PfamPF00962. A_deaminase. 1 hit.
[Graphical view]
TIGRFAMsTIGR01430. Aden_deam. 1 hit.
PROSITEPS00485. A_DEAMINASE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameADD_MYCLE
AccessionPrimary (citable) accession number: Q9CCL9
Secondary accession number(s): Q49907
Entry history
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: June 1, 2001
Last modified: January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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