Reviewed, UniProtKB/Swiss-Prot Q9CCL9 (ADD_MYCLE)

Names and origin

Protein names

Recommended name:
    Adenosine deaminase
    EC=3.5.4.4
Alternative name(s):
    Adenosine aminohydrolase

Gene names

Name:	add
Ordered Locus Names:	ML0700
ORF Names:	L308_C2_206

Organism

Mycobacterium leprae [Complete proteome] [HAMAP]

Taxonomic identifier

1769 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Adenosine + H2O = inosine + NH3. HAMAP MF_00540
Sequence similarities	Belongs to the adenosine and AMP deaminases family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	adenosine deaminase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 362	362	Adenosine deaminase HAMAP MF_00540		PRO_0000194373
Sites
	Active site	208	1	Potential
	Active site	267	1	Potential
	Active site	300	1	Potential
	Active site	301	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9CCL9-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: ED0C43B5C92908F5	FASTA	362	39,637
	10 20 30 40 50 60 MNTPLHLENI KQAPKALLHD HLDGGLRPAT VLDIAGQVGY DRLPATDVES LETWFRTASH 70 80 90 100 110 120 SGSLERYLEP FSHTVAVMQT PEALHRVAYE CVEDLAADSV VYAEVRFAPE LHIDEGLSFD 130 140 150 160 170 180 EVLASVLAGF ADGERACAAE GNAITVRCLV TAMRHAAMSR EIAELAIRFR DKGVVGFDIA 190 200 210 220 230 240 GAEAGHPPTR HLDAFEYMRS NNARFTIHAG EAFGLPSIHE AIAFCGADRL GHGVRIVDDI 250 260 270 280 290 300 DVDPGGGIRL GPLASILRDK RIPLELCPSS NLQTGAVASI TEHPFDLLAW ARFRVTVNTD 310 320 330 340 350 360 NRLMSDTSMS LEMHRLVEAF GYGWGDLERF TINAMKSAFI PFDQRLAIID EVIKPRFAVL VG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Smith D.R., Robison K. Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Massive gene decay in the leprosy bacillus." Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S. , Feltwell T., Fraser A., Hamlin N., Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S., Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R., Barrell B.G. Nature 409:1007-1011(2001) [PubMed: 11234002] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TN.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00022 Genomic DNA. Translation: AAA17330.1. Different initiation. AL583919 Genomic DNA. Translation: CAC30209.1.
PIR	E86996. S73031.
RefSeq	NP_301559.1.
3D structure databases
SMR	Q9CCL9. Positions 12-354.
ModBase	Search...
Genome annotation databases
GeneID	910518.
KEGG	mle:ML0700.
NMPDR	fig|272631.1.peg.431.
Organism-specific databases
Leproma	ML0700.
CMR	Search...
Phylogenomic databases
HOGENOM	HBG630382.
OMA	FLKKLDW.
Enzyme and pathway databases
BioCyc	MLEP272631:ML0700-MONOMER.
BRENDA	3.5.4.4. 808.
Family and domain databases
HAMAP	MF_00540. A_deaminase. [Tree]
InterPro	IPR001365. A/AMP_deaminase. IPR006330. A_deaminase. [Graphical view]
PANTHER	PTHR11409. A/AMP_deaminase. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. aden_deam. 1 hit.
PROSITE	PS00485. A_DEAMINASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADD_MYCLE

Accession

Primary (citable) accession number: Q9CCL9
Secondary accession number(s): Q49907

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 5, 2002
Last sequence update:	June 1, 2001
Last modified:	February 9, 2010
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)