Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Adenosine deaminase

Gene

add

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Adenosine + H2O = inosine + NH3.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi19 – 191Zinc; catalyticUniRule annotation
Metal bindingi21 – 211Zinc; catalyticUniRule annotation
Binding sitei21 – 211SubstrateUniRule annotation
Binding sitei23 – 231SubstrateUniRule annotation
Binding sitei181 – 1811Substrate; via amide nitrogen and carbonyl oxygenUniRule annotation
Metal bindingi208 – 2081Zinc; catalyticUniRule annotation
Active sitei211 – 2111Proton donorUniRule annotation
Sitei232 – 2321Important for catalytic activityUniRule annotation
Metal bindingi300 – 3001Zinc; catalyticUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine deaminaseUniRule annotation (EC:3.5.4.4UniRule annotation)
Alternative name(s):
Adenosine aminohydrolaseUniRule annotation
Gene namesi
Name:addUniRule annotation
Ordered Locus Names:ML0700
ORF Names:L308_C2_206
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0700.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 362362Adenosine deaminasePRO_0000194373Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272631.ML0700.

Structurei

3D structure databases

ProteinModelPortaliQ9CCL9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosine and AMP deaminases family. Adenosine deaminase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EKD. Bacteria.
COG1816. LUCA.
HOGENOMiHOG000218816.
KOiK01488.
OMAiDWMVAVL.
OrthoDBiPOG091H02QG.

Family and domain databases

HAMAPiMF_00540. A_deaminase. 1 hit.
InterProiIPR001365. A/AMP_deaminase_dom.
IPR028893. A_deaminase.
IPR006330. Ado/ade_deaminase.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF00962. A_deaminase. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR01430. aden_deam. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CCL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTPLHLENI KQAPKALLHD HLDGGLRPAT VLDIAGQVGY DRLPATDVES
60 70 80 90 100
LETWFRTASH SGSLERYLEP FSHTVAVMQT PEALHRVAYE CVEDLAADSV
110 120 130 140 150
VYAEVRFAPE LHIDEGLSFD EVLASVLAGF ADGERACAAE GNAITVRCLV
160 170 180 190 200
TAMRHAAMSR EIAELAIRFR DKGVVGFDIA GAEAGHPPTR HLDAFEYMRS
210 220 230 240 250
NNARFTIHAG EAFGLPSIHE AIAFCGADRL GHGVRIVDDI DVDPGGGIRL
260 270 280 290 300
GPLASILRDK RIPLELCPSS NLQTGAVASI TEHPFDLLAW ARFRVTVNTD
310 320 330 340 350
NRLMSDTSMS LEMHRLVEAF GYGWGDLERF TINAMKSAFI PFDQRLAIID
360
EVIKPRFAVL VG
Length:362
Mass (Da):39,637
Last modified:June 1, 2001 - v1
Checksum:iED0C43B5C92908F5
GO

Sequence cautioni

The sequence AAA17330 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00022 Genomic DNA. Translation: AAA17330.1. Different initiation.
AL583919 Genomic DNA. Translation: CAC30209.1.
PIRiE86996.
S73031.
RefSeqiNP_301559.1. NC_002677.1.
WP_010907883.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30209; CAC30209; CAC30209.
GeneIDi910518.
KEGGimle:ML0700.
PATRICi18052626. VBIMycLep78757_1259.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00022 Genomic DNA. Translation: AAA17330.1. Different initiation.
AL583919 Genomic DNA. Translation: CAC30209.1.
PIRiE86996.
S73031.
RefSeqiNP_301559.1. NC_002677.1.
WP_010907883.1. NC_002677.1.

3D structure databases

ProteinModelPortaliQ9CCL9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML0700.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC30209; CAC30209; CAC30209.
GeneIDi910518.
KEGGimle:ML0700.
PATRICi18052626. VBIMycLep78757_1259.

Organism-specific databases

LepromaiML0700.

Phylogenomic databases

eggNOGiENOG4105EKD. Bacteria.
COG1816. LUCA.
HOGENOMiHOG000218816.
KOiK01488.
OMAiDWMVAVL.
OrthoDBiPOG091H02QG.

Family and domain databases

HAMAPiMF_00540. A_deaminase. 1 hit.
InterProiIPR001365. A/AMP_deaminase_dom.
IPR028893. A_deaminase.
IPR006330. Ado/ade_deaminase.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF00962. A_deaminase. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR01430. aden_deam. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADD_MYCLE
AccessioniPrimary (citable) accession number: Q9CCL9
Secondary accession number(s): Q49907
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.