Q9CCL9 (ADD_MYCLE) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 61.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Adenosine deaminase EC=3.5.4.4 Alternative name(s): Adenosine aminohydrolase | ||||||
| Gene names |
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| Organism | Mycobacterium leprae [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 1769 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium |
Protein attributes
| Sequence length | 362 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | Adenosine + H2O = inosine + NH3. HAMAP MF_00540 |
| Cofactor | Binds 1 zinc ion per subunit By similarity. HAMAP MF_00540 |
| Sequence similarities | Belongs to the adenosine and AMP deaminases family. Adenosine deaminase subfamily. |
| Sequence caution | The sequence AAA17330.1 differs from that shown. Reason: Erroneous initiation. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Nucleotide metabolism |
| Ligand | Metal-binding Zinc |
| Molecular function | Hydrolase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: InterPro |
| Molecular function | adenosine deaminase activity Inferred from electronic annotation. Source: EC metal ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 362 | 362 | Adenosine deaminase HAMAP MF_00540 | PRO_0000194373 | |||||
Sites | |||||||||
| Active site | 211 | 1 | Proton donor By similarity | ||||||
| Metal binding | 19 | 1 | Zinc; catalytic By similarity | ||||||
| Metal binding | 21 | 1 | Zinc; catalytic By similarity | ||||||
| Metal binding | 208 | 1 | Zinc; catalytic By similarity | ||||||
| Metal binding | 300 | 1 | Zinc; catalytic By similarity | ||||||
| Binding site | 21 | 1 | Substrate By similarity | ||||||
| Binding site | 23 | 1 | Substrate By similarity | ||||||
| Binding site | 181 | 1 | Substrate; via amide nitrogen and carbonyl oxygen By similarity | ||||||
| Site | 232 | 1 | Important for catalytic activity By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | Smith D.R., Robison K. Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "Massive gene decay in the leprosy bacillus." Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S. Barrell B.G.Nature 409:1007-1011(2001) [PubMed: 11234002] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TN. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U00022 Genomic DNA. Translation: AAA17330.1. Different initiation. AL583919 Genomic DNA. Translation: CAC30209.1. |
| PIR | E86996. S73031. |
| RefSeq | NP_301559.1. NC_002677.1. |
3D structure databases | |
| ProteinModelPortal | Q9CCL9. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBMYCT00000028687; EBMYCP00000028293; EBMYCG00000028682. |
| GeneID | 910518. |
| GenomeReviews | Gene locus ML0700 in contig AL450380_GR. |
| KEGG | mle:ML0700. |
| NMPDR | fig|272631.1.peg.431. |
| PATRIC | 18052626. VBIMycLep78757_1259. |
Organism-specific databases | |
| Leproma | ML0700. |
| CMR | Search... |
Phylogenomic databases | |
| GeneTree | EBGT00050000016615. |
| HOGENOM | HBG630382. |
| OMA | PYYMAMN. |
| ProtClustDB | PRK09358. |
Enzyme and pathway databases | |
| BioCyc | MLEP272631:ML0700-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00540. A_deaminase. [Tree] |
| InterPro | IPR001365. A/AMP_deaminase_dom. IPR006330. A_deaminase. [Graphical view] |
| KO | K01488. |
| PANTHER | PTHR11409:SF21. PTHR11409:SF21. 1 hit. |
| Pfam | PF00962. A_deaminase. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01430. Aden_deam. 1 hit. |
| PROSITE | PS00485. A_DEAMINASE. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ADD_MYCLE | ||||||||
| Accession | Primary (citable) accession number: Q9CCL9 Secondary accession number(s): Q49907 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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