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Protein

Adenosine deaminase

Gene

add

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Adenosine + H2O = inosine + NH3.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi19Zinc; catalyticUniRule annotation1
Metal bindingi21Zinc; catalyticUniRule annotation1
Binding sitei21SubstrateUniRule annotation1
Binding sitei23SubstrateUniRule annotation1
Binding sitei181Substrate; via amide nitrogen and carbonyl oxygenUniRule annotation1
Metal bindingi208Zinc; catalyticUniRule annotation1
Active sitei211Proton donorUniRule annotation1
Sitei232Important for catalytic activityUniRule annotation1
Metal bindingi300Zinc; catalyticUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciMLEP272631:G1GT5-766-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine deaminaseUniRule annotation (EC:3.5.4.4UniRule annotation)
Alternative name(s):
Adenosine aminohydrolaseUniRule annotation
Gene namesi
Name:addUniRule annotation
Ordered Locus Names:ML0700
ORF Names:L308_C2_206
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0700

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001943731 – 362Adenosine deaminaseAdd BLAST362

Interactioni

Protein-protein interaction databases

STRINGi272631.ML0700

Structurei

3D structure databases

ProteinModelPortaliQ9CCL9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EKD Bacteria
COG1816 LUCA
HOGENOMiHOG000218816
KOiK01488
OMAiQWCGADR
OrthoDBiPOG091H02QG

Family and domain databases

HAMAPiMF_00540 A_deaminase, 1 hit
InterProiView protein in InterPro
IPR001365 A/AMP_deaminase_dom
IPR028893 A_deaminase
IPR006330 Ado/ade_deaminase
IPR032466 Metal_Hydrolase
PfamiView protein in Pfam
PF00962 A_deaminase, 1 hit
SUPFAMiSSF51556 SSF51556, 1 hit
TIGRFAMsiTIGR01430 aden_deam, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CCL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTPLHLENI KQAPKALLHD HLDGGLRPAT VLDIAGQVGY DRLPATDVES
60 70 80 90 100
LETWFRTASH SGSLERYLEP FSHTVAVMQT PEALHRVAYE CVEDLAADSV
110 120 130 140 150
VYAEVRFAPE LHIDEGLSFD EVLASVLAGF ADGERACAAE GNAITVRCLV
160 170 180 190 200
TAMRHAAMSR EIAELAIRFR DKGVVGFDIA GAEAGHPPTR HLDAFEYMRS
210 220 230 240 250
NNARFTIHAG EAFGLPSIHE AIAFCGADRL GHGVRIVDDI DVDPGGGIRL
260 270 280 290 300
GPLASILRDK RIPLELCPSS NLQTGAVASI TEHPFDLLAW ARFRVTVNTD
310 320 330 340 350
NRLMSDTSMS LEMHRLVEAF GYGWGDLERF TINAMKSAFI PFDQRLAIID
360
EVIKPRFAVL VG
Length:362
Mass (Da):39,637
Last modified:June 1, 2001 - v1
Checksum:iED0C43B5C92908F5
GO

Sequence cautioni

The sequence AAA17330 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00022 Genomic DNA Translation: AAA17330.1 Different initiation.
AL583919 Genomic DNA Translation: CAC30209.1
PIRiE86996
S73031
RefSeqiNP_301559.1, NC_002677.1
WP_010907883.1, NC_002677.1

Genome annotation databases

EnsemblBacteriaiCAC30209; CAC30209; CAC30209
GeneIDi910518
KEGGimle:ML0700
PATRICifig|272631.5.peg.1259

Similar proteinsi

Entry informationi

Entry nameiADD_MYCLE
AccessioniPrimary (citable) accession number: Q9CCL9
Secondary accession number(s): Q49907
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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