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Protein

Adenosylhomocysteinase

Gene

ahcY

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.UniRule annotation

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.UniRule annotation

Cofactori

NAD+UniRule annotationNote: Binds 1 NAD+ per subunit.UniRule annotation

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (ahcY)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei68SubstrateUniRule annotation1
Binding sitei153SubstrateUniRule annotation1
Binding sitei215SubstrateUniRule annotation1
Binding sitei245SubstrateUniRule annotation1
Binding sitei249SubstrateUniRule annotation1
Binding sitei250NADUniRule annotation1
Binding sitei302NADUniRule annotation1
Binding sitei337NADUniRule annotation1
Binding sitei406NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi216 – 218NADUniRule annotation3
Nucleotide bindingi279 – 284NADUniRule annotation6
Nucleotide bindingi358 – 360NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00314; UER00076.

Names & Taxonomyi

Protein namesi
Recommended name:
AdenosylhomocysteinaseUniRule annotation (EC:3.3.1.1UniRule annotation)
Alternative name(s):
S-adenosyl-L-homocysteine hydrolaseUniRule annotation
Short name:
AdoHcyaseUniRule annotation
Gene namesi
Name:ahcYUniRule annotation
Synonyms:sahH
Ordered Locus Names:ML0771
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0771.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001169681 – 492AdenosylhomocysteinaseAdd BLAST492

Interactioni

Protein-protein interaction databases

STRINGi272631.ML0771.

Structurei

3D structure databases

ProteinModelPortaliQ9CCJ4.
SMRiQ9CCJ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C3E. Bacteria.
COG0499. LUCA.
HOGENOMiHOG000227986.
KOiK01251.
OMAiTGNRDII.
OrthoDBiPOG091H00W2.

Family and domain databases

CDDicd00401. SAHH. 1 hit.
HAMAPiMF_00563. AdoHcyase. 1 hit.
InterProiView protein in InterPro
IPR034373. Adenosylhomocysteinase.
IPR000043. Adenosylhomocysteinase-like.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR036291. NAD(P)-bd_dom_sf.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
PANTHERiPTHR23420. PTHR23420. 1 hit.
PfamiView protein in Pfam
PF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
PIRSFiPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTiView protein in SMART
SM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00936. ahcY. 1 hit.
PROSITEiView protein in PROSITE
PS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CCJ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTTENSLMP DVRNGIDFKV ADLSLANFGR KELDLAEYEM PGLMSLRHEY
60 70 80 90 100
AEVQPLKGAR ISGSLHMTVQ TAVLIETLTA LGAEVRWASC NIFSTQDHAA
110 120 130 140 150
AAVVVGPYGT PEEPKGVPVF AWKGETLEEY WWAAEQMLTW PDPDKPVNMI
160 170 180 190 200
LDDGGDATML VLRGVQYEKA GVVPPAEVDD SAEWKVFLNL LRKRFETDKG
210 220 230 240 250
KWTKIAKSVK GVTEETTTGV LRLYQFAAAG DLAFPAINVN DSVTKSKFDN
260 270 280 290 300
KYGTRHSLID GINRGTDSLI GGKNVLICGY GDVGKGCAEA AKGQGARVTI
310 320 330 340 350
TEIDPINALQ ALMEGFDVKR VEDVIADSDI VVTATGNKDI ILLEHMKAMK
360 370 380 390 400
DHAILGNIGH FDNEIDMAAL ERSGATRLNI KPQVDLWTFG DSGKSIIVLS
410 420 430 440 450
EGRLLNLGNA TGHPSFVMSN SFANQTIAQI ELWTKNDDYD NEVYRLPKHL
460 470 480 490
DEKVARVHVE ALGGQLTKLT KDQAEYLGVD VDGPFKPDHY RY
Length:492
Mass (Da):53,986
Last modified:June 1, 2001 - v1
Checksum:iDE83D454CF87EEB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583919 Genomic DNA. Translation: CAC30280.1.
PIRiD87005.
RefSeqiNP_301595.1. NC_002677.1.
WP_010907919.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30280; CAC30280; CAC30280.
GeneIDi910325.
KEGGimle:ML0771.
PATRICifig|272631.5.peg.1389.

Similar proteinsi

Entry informationi

Entry nameiSAHH_MYCLE
AccessioniPrimary (citable) accession number: Q9CCJ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: June 1, 2001
Last modified: October 25, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families