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Protein

Sensor histidine kinase MtrB

Gene

mtrB

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Member of the two-component regulatory system MtrA/MtrB. Seems to function as a membrane-associated protein kinase that phosphorylates MtrA in response to environmental signals (By similarity).By similarity

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Two-component regulatory system

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sensor histidine kinase MtrB (EC:2.7.13.3)
Gene namesi
Name:mtrB
Ordered Locus Names:ML0774
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0774.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Transmembranei213 – 233HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000748071 – 562Sensor histidine kinase MtrBAdd BLAST562

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi272631.ML0774.

Structurei

3D structure databases

ProteinModelPortaliQ9CCJ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini235 – 287HAMPPROSITE-ProRule annotationAdd BLAST53
Domaini302 – 519Histidine kinasePROSITE-ProRule annotationAdd BLAST218

Sequence similaritiesi

Contains 1 HAMP domain.PROSITE-ProRule annotation
Contains 1 histidine kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZU. Bacteria.
ENOG410XNMH. LUCA.
HOGENOMiHOG000247709.
KOiK07654.
OMAiNSEQSTI.
OrthoDBiPOG091H0351.

Family and domain databases

CDDicd06225. HAMP. 1 hit.
Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003660. HAMP_dom.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00304. HAMP. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CCJ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIFSSRRRIR GRWGRSGPMM RGMGALTRVV GVVWRRSLQL RVVALTFGLS
60 70 80 90 100
LAVILALGFV LTSQLTSRVL DVKVRVAIEQ IERARTTVTG IVNGEETRSL
110 120 130 140 150
DSSLQLARNT LTSKTDPTSG AGLVGAFDAV LIVPGDGPRT ATTAGPVDQV
160 170 180 190 200
PNSLRGFIKA GQAAYQYATV HTEGFSGPAL IIGTPTSSQV TNLELYLIFP
210 220 230 240 250
LKNEQATVTL VRGTMATGGM VLLVLLSGIA LLVSRQVVVP VRSASRIAER
260 270 280 290 300
FAEGHLSERM PVRGEDDMAR LAVSFNDMAE SLSRQITQLE EFGNLQRRFT
310 320 330 340 350
SDVSHELRTP LTTVRMAADL IYDHSSDLDP TLRRSTELMV SELDRFETLL
360 370 380 390 400
NDLLEISRHD AGVAELSVEA VDLRVMVNNA LGNVGHLAEE AGIELLVDMP
410 420 430 440 450
VDEVIAEVDA RRVERILRNL IANAIDHSEH KPVRIRMAAD EDTVAVTVRD
460 470 480 490 500
YGIGLRPGEE KLVFSRFWRS DPSRVRRSGG TGLGLAISIE DARLHQGRLE
510 520 530 540 550
AWGEPGQGAC FRLTLPLVRG HKVTTSPLPM KPILQPSPQA STAGQQHGTQ
560
RQRLREHAER SR
Length:562
Mass (Da):61,506
Last modified:June 1, 2001 - v1
Checksum:i741EB0087AEC155E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583919 Genomic DNA. Translation: CAC30283.1.
PIRiG87005.
RefSeqiNP_301598.1. NC_002677.1.
WP_010907922.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30283; CAC30283; CAC30283.
GeneIDi909729.
KEGGimle:ML0774.
PATRICi18052892. VBIMycLep78757_1392.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583919 Genomic DNA. Translation: CAC30283.1.
PIRiG87005.
RefSeqiNP_301598.1. NC_002677.1.
WP_010907922.1. NC_002677.1.

3D structure databases

ProteinModelPortaliQ9CCJ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML0774.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC30283; CAC30283; CAC30283.
GeneIDi909729.
KEGGimle:ML0774.
PATRICi18052892. VBIMycLep78757_1392.

Organism-specific databases

LepromaiML0774.

Phylogenomic databases

eggNOGiENOG4105BZU. Bacteria.
ENOG410XNMH. LUCA.
HOGENOMiHOG000247709.
KOiK07654.
OMAiNSEQSTI.
OrthoDBiPOG091H0351.

Family and domain databases

CDDicd06225. HAMP. 1 hit.
Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003660. HAMP_dom.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00304. HAMP. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTRB_MYCLE
AccessioniPrimary (citable) accession number: Q9CCJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.