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Q9CCF8

- PNP_MYCLE

UniProt

Q9CCF8 - PNP_MYCLE

Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

    Catalytic activityi

    RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi532 – 5321MagnesiumUniRule annotation
    Metal bindingi538 – 5381MagnesiumUniRule annotation

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: InterPro
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
    4. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA catabolic process Source: UniProtKB-HAMAP
    2. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
    Alternative name(s):
    Polynucleotide phosphorylaseUniRule annotation
    Short name:
    PNPaseUniRule annotation
    Gene namesi
    Name:pnpUniRule annotation
    Ordered Locus Names:ML0854
    OrganismiMycobacterium leprae (strain TN)
    Taxonomic identifieri272631 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000806: Chromosome

    Organism-specific databases

    LepromaiML0854.

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 773773Polyribonucleotide nucleotidyltransferasePRO_0000329718Add
    BLAST

    Proteomic databases

    PRIDEiQ9CCF8.

    Interactioni

    Protein-protein interaction databases

    STRINGi272631.ML0854.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CCF8.
    SMRiQ9CCF8. Positions 13-732.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini598 – 65760KHUniRule annotationAdd
    BLAST
    Domaini669 – 73870S1 motifUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
    Contains 1 KH domain.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1185.
    HOGENOMiHOG000218326.
    KOiK00962.
    OMAiPRWDWVA.
    OrthoDBiEOG6WT8CC.

    Family and domain databases

    Gene3Di1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPiMF_01595. PNPase.
    InterProiIPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR014069. pppGpp_PNP.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view]
    PANTHERiPTHR11252. PTHR11252. 1 hit.
    PfamiPF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005499. PNPase. 1 hit.
    SMARTiSM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
    TIGR02696. pppGpp_PNP. 1 hit.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9CCF8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVAEIEEGV FEATVTIDNG SFGTRAIRFE TGRLALQAAG AVVAYLDADN    50
    MLLSATTASK NPKEQFDFFP LTVDVEERMY AAGRIPGSFF RREGRPSTDA 100
    ILTCRLIDRP LRPSFVDGLR NEIQVVVTIL SVDPNDLYDV LAINAASAST 150
    QLGGLPFSGP IGGVRVALID GTWVAFPTVE QLERAVFDMV IAGRIVGTDD 200
    EGKPDVAIMM VEAEATENVI ELVECGAQAP TESIVAQGLE VAKPFIAALC 250
    TAQQELADVV SSRQAKPPVE YPTFPDYGDD VYYSVASMAT DELAAALTIG 300
    AKLERDQRTN EIKTQVLERL AGTYEGREKE LGAAFRSLTK KLVRQRILTN 350
    HFRIDGRGIT DIRALSAEVA VVPRAHGSAL FERGETQILG VTTLDMVKMA 400
    QQIDSLGPET SKRYMHHYNF PPFSTGETGR VGSPKRREIG HGALAERALV 450
    PVLPSVEEFP YAIRQVSEAL GSNGSTSMGS VCASTLALLN AGVPLKAPVA 500
    GIAMGLVSDD VEFDGGTERR FVTLTDILGA EDAFGDMDFK CAGTKDFVTA 550
    LQLDTKLDGI PSQVLAGALA QAKDARLTIL EVMAEAIDRP DEMSPYAPRV 600
    ITIKVPVDKI GEVIGPKGKV INAITEETGA QISIEDDGTV FVGATDGLSA 650
    QAAINKINAI ANPQLPTVGE RFLGTVVKIT EFGAFVSLLP GRDGLVHISK 700
    LGKGKRIAKV EDVVNVGDKL RVEIADIEKR GKISLVLVAD DDSATVPAAP 750
    ADAGAAQEFG SGTAPADAAT ASS 773
    Length:773
    Mass (Da):82,047
    Last modified:June 1, 2001 - v1
    Checksum:i25B9790BF6125D73
    GO

    Sequence cautioni

    The sequence CAB11392.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z98741 Genomic DNA. Translation: CAB11392.1. Different initiation.
    AL583920 Genomic DNA. Translation: CAC31235.1.
    PIRiH87015.
    T44900.
    RefSeqiNP_301643.1. NC_002677.1.
    WP_010907967.1. NC_002677.1.

    Genome annotation databases

    EnsemblBacteriaiCAC31235; CAC31235; CAC31235.
    GeneIDi909849.
    KEGGimle:ML0854.
    PATRICi18053264. VBIMycLep78757_1577.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z98741 Genomic DNA. Translation: CAB11392.1 . Different initiation.
    AL583920 Genomic DNA. Translation: CAC31235.1 .
    PIRi H87015.
    T44900.
    RefSeqi NP_301643.1. NC_002677.1.
    WP_010907967.1. NC_002677.1.

    3D structure databases

    ProteinModelPortali Q9CCF8.
    SMRi Q9CCF8. Positions 13-732.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272631.ML0854.

    Proteomic databases

    PRIDEi Q9CCF8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC31235 ; CAC31235 ; CAC31235 .
    GeneIDi 909849.
    KEGGi mle:ML0854.
    PATRICi 18053264. VBIMycLep78757_1577.

    Organism-specific databases

    Lepromai ML0854.

    Phylogenomic databases

    eggNOGi COG1185.
    HOGENOMi HOG000218326.
    KOi K00962.
    OMAi PRWDWVA.
    OrthoDBi EOG6WT8CC.

    Family and domain databases

    Gene3Di 1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPi MF_01595. PNPase.
    InterProi IPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR014069. pppGpp_PNP.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view ]
    PANTHERi PTHR11252. PTHR11252. 1 hit.
    Pfami PF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005499. PNPase. 1 hit.
    SMARTi SM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
    TIGR02696. pppGpp_PNP. 1 hit.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TN.

    Entry informationi

    Entry nameiPNP_MYCLE
    AccessioniPrimary (citable) accession number: Q9CCF8
    Secondary accession number(s): O32966
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3