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Q9CCF8

- PNP_MYCLE

UniProt

Q9CCF8 - PNP_MYCLE

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, ML0854
Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi532 – 5321Magnesium By similarity
Metal bindingi538 – 5381Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:ML0854
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML0854.

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 773773Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_0000329718Add
BLAST

Proteomic databases

PRIDEiQ9CCF8.

Interactioni

Protein-protein interaction databases

STRINGi272631.ML0854.

Structurei

3D structure databases

ProteinModelPortaliQ9CCF8.
SMRiQ9CCF8. Positions 13-732.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini598 – 65760KH
Add
BLAST
Domaini669 – 73870S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CCF8-1 [UniParc]FASTAAdd to Basket

« Hide

MSVAEIEEGV FEATVTIDNG SFGTRAIRFE TGRLALQAAG AVVAYLDADN    50
MLLSATTASK NPKEQFDFFP LTVDVEERMY AAGRIPGSFF RREGRPSTDA 100
ILTCRLIDRP LRPSFVDGLR NEIQVVVTIL SVDPNDLYDV LAINAASAST 150
QLGGLPFSGP IGGVRVALID GTWVAFPTVE QLERAVFDMV IAGRIVGTDD 200
EGKPDVAIMM VEAEATENVI ELVECGAQAP TESIVAQGLE VAKPFIAALC 250
TAQQELADVV SSRQAKPPVE YPTFPDYGDD VYYSVASMAT DELAAALTIG 300
AKLERDQRTN EIKTQVLERL AGTYEGREKE LGAAFRSLTK KLVRQRILTN 350
HFRIDGRGIT DIRALSAEVA VVPRAHGSAL FERGETQILG VTTLDMVKMA 400
QQIDSLGPET SKRYMHHYNF PPFSTGETGR VGSPKRREIG HGALAERALV 450
PVLPSVEEFP YAIRQVSEAL GSNGSTSMGS VCASTLALLN AGVPLKAPVA 500
GIAMGLVSDD VEFDGGTERR FVTLTDILGA EDAFGDMDFK CAGTKDFVTA 550
LQLDTKLDGI PSQVLAGALA QAKDARLTIL EVMAEAIDRP DEMSPYAPRV 600
ITIKVPVDKI GEVIGPKGKV INAITEETGA QISIEDDGTV FVGATDGLSA 650
QAAINKINAI ANPQLPTVGE RFLGTVVKIT EFGAFVSLLP GRDGLVHISK 700
LGKGKRIAKV EDVVNVGDKL RVEIADIEKR GKISLVLVAD DDSATVPAAP 750
ADAGAAQEFG SGTAPADAAT ASS 773
Length:773
Mass (Da):82,047
Last modified:June 1, 2001 - v1
Checksum:i25B9790BF6125D73
GO

Sequence cautioni

The sequence CAB11392.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z98741 Genomic DNA. Translation: CAB11392.1. Different initiation.
AL583920 Genomic DNA. Translation: CAC31235.1.
PIRiH87015.
T44900.
RefSeqiNP_301643.1. NC_002677.1.
WP_010907967.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31235; CAC31235; CAC31235.
GeneIDi909849.
KEGGimle:ML0854.
PATRICi18053264. VBIMycLep78757_1577.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z98741 Genomic DNA. Translation: CAB11392.1 . Different initiation.
AL583920 Genomic DNA. Translation: CAC31235.1 .
PIRi H87015.
T44900.
RefSeqi NP_301643.1. NC_002677.1.
WP_010907967.1. NC_002677.1.

3D structure databases

ProteinModelPortali Q9CCF8.
SMRi Q9CCF8. Positions 13-732.
ModBasei Search...

Protein-protein interaction databases

STRINGi 272631.ML0854.

Proteomic databases

PRIDEi Q9CCF8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC31235 ; CAC31235 ; CAC31235 .
GeneIDi 909849.
KEGGi mle:ML0854.
PATRICi 18053264. VBIMycLep78757_1577.

Organism-specific databases

Lepromai ML0854.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiPNP_MYCLE
AccessioniPrimary (citable) accession number: Q9CCF8
Secondary accession number(s): O32966
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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