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Protein

Probable cytochrome c oxidase subunit 2

Gene

ctaC

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity).By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • Cu cationBy similarityNote: Binds a copper A center.By similarity
  • hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi246Copper ASequence analysis1
Metal bindingi287Copper ASequence analysis1
Metal bindingi291Copper ASequence analysis1
Metal bindingi295Copper ASequence analysis1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Enzyme and pathway databases

BioCyciMLEP272631:G1GT5-952-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Gene namesi
Name:ctaC
Ordered Locus Names:ML0875
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0875

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei63 – 83HelicalSequence analysisAdd BLAST21
Transmembranei110 – 130HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 42Sequence analysisAdd BLAST42
ChainiPRO_000000605643 – 353Probable cytochrome c oxidase subunit 2Add BLAST311

Interactioni

Protein-protein interaction databases

STRINGi272631.ML0875

Structurei

3D structure databases

ProteinModelPortaliQ9CCF1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CV4 Bacteria
COG1622 LUCA
HOGENOMiHOG000245527
KOiK02275
OMAiHAFMPIA
OrthoDBiPOG091H05L4

Family and domain databases

Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
SUPFAMiSSF49503 SSF49503, 2 hits
SSF81464 SSF81464, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CCF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTARELVCSQ RVGQGLSRRL RPLVLAVTLG VLVVTLSGCS WSDALAIGWP
60 70 80 90 100
EGITPEAHLN RQLWIGAVVA SLVVGVIVWG LIFWSTIFHR KKTTDTELPR
110 120 130 140 150
QFGYNMPLEL VLTVTPFLII SMLFYFTVIV QDKMLYLAKD PEVVIDVTAF
160 170 180 190 200
QWNWKFGYQR VDFKDGTLTY DGVDPARKKA MVSKPEGKDS HGEELVGAVR
210 220 230 240 250
GLNTEDRAYL NFDKVETLGT TTEIPVLVLP AGKRIEFQLN SADVVHSFWV
260 270 280 290 300
PKFLFKRDVM PNPVANNSVN VFQVEEITKT GAFVGHCAEM CGTYHSMMNF
310 320 330 340 350
EVRVVAPNDF KAYLQQRIDG KTNAEALQVI AQPPLAVTTH PFDTRRGQLT

NSQ
Length:353
Mass (Da):39,521
Last modified:June 1, 2001 - v1
Checksum:iAA6BFCAB69A27A20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583920 Genomic DNA Translation: CAC31256.1
PIRiE87018
RefSeqiNP_301661.1, NC_002677.1
WP_010907985.1, NC_002677.1

Genome annotation databases

EnsemblBacteriaiCAC31256; CAC31256; CAC31256
GeneIDi909877
KEGGimle:ML0875
PATRICifig|272631.5.peg.1605

Similar proteinsi

Entry informationi

Entry nameiCOX2_MYCLE
AccessioniPrimary (citable) accession number: Q9CCF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health