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Q9CCF1

- COX2_MYCLE

UniProt

Q9CCF1 - COX2_MYCLE

Protein

Probable cytochrome c oxidase subunit 2

Gene

ctaC

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) By similarity.By similarity

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Copper A.By similarity
    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi246 – 2461Copper ASequence Analysis
    Metal bindingi287 – 2871Copper ASequence Analysis
    Metal bindingi291 – 2911Copper ASequence Analysis
    Metal bindingi295 – 2951Copper ASequence Analysis

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable cytochrome c oxidase subunit 2 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome aa3 subunit 2
    Cytochrome c oxidase polypeptide II
    Gene namesi
    Name:ctaC
    Ordered Locus Names:ML0875
    OrganismiMycobacterium leprae (strain TN)
    Taxonomic identifieri272631 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000806: Chromosome

    Organism-specific databases

    LepromaiML0875.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 4242Sequence AnalysisAdd
    BLAST
    Chaini43 – 353311Probable cytochrome c oxidase subunit 2PRO_0000006056Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272631.ML0875.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CCF1.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei63 – 8321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei110 – 13021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1622.
    HOGENOMiHOG000245527.
    KOiK02275.
    OMAiMRELWTW.
    OrthoDBiEOG68SVXT.

    Family and domain databases

    Gene3Di1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProiIPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view]
    PfamiPF00116. COX2. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 2 hits.
    SSF81464. SSF81464. 1 hit.
    PROSITEiPS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9CCF1-1 [UniParc]FASTAAdd to Basket

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    MTARELVCSQ RVGQGLSRRL RPLVLAVTLG VLVVTLSGCS WSDALAIGWP    50
    EGITPEAHLN RQLWIGAVVA SLVVGVIVWG LIFWSTIFHR KKTTDTELPR 100
    QFGYNMPLEL VLTVTPFLII SMLFYFTVIV QDKMLYLAKD PEVVIDVTAF 150
    QWNWKFGYQR VDFKDGTLTY DGVDPARKKA MVSKPEGKDS HGEELVGAVR 200
    GLNTEDRAYL NFDKVETLGT TTEIPVLVLP AGKRIEFQLN SADVVHSFWV 250
    PKFLFKRDVM PNPVANNSVN VFQVEEITKT GAFVGHCAEM CGTYHSMMNF 300
    EVRVVAPNDF KAYLQQRIDG KTNAEALQVI AQPPLAVTTH PFDTRRGQLT 350
    NSQ 353
    Length:353
    Mass (Da):39,521
    Last modified:June 1, 2001 - v1
    Checksum:iAA6BFCAB69A27A20
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL583920 Genomic DNA. Translation: CAC31256.1.
    PIRiE87018.
    RefSeqiNP_301661.1. NC_002677.1.
    WP_010907985.1. NC_002677.1.

    Genome annotation databases

    EnsemblBacteriaiCAC31256; CAC31256; CAC31256.
    GeneIDi909877.
    KEGGimle:ML0875.
    PATRICi18053320. VBIMycLep78757_1605.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL583920 Genomic DNA. Translation: CAC31256.1 .
    PIRi E87018.
    RefSeqi NP_301661.1. NC_002677.1.
    WP_010907985.1. NC_002677.1.

    3D structure databases

    ProteinModelPortali Q9CCF1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272631.ML0875.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC31256 ; CAC31256 ; CAC31256 .
    GeneIDi 909877.
    KEGGi mle:ML0875.
    PATRICi 18053320. VBIMycLep78757_1605.

    Organism-specific databases

    Lepromai ML0875.

    Phylogenomic databases

    eggNOGi COG1622.
    HOGENOMi HOG000245527.
    KOi K02275.
    OMAi MRELWTW.
    OrthoDBi EOG68SVXT.

    Family and domain databases

    Gene3Di 1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProi IPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view ]
    Pfami PF00116. COX2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 2 hits.
    SSF81464. SSF81464. 1 hit.
    PROSITEi PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TN.

    Entry informationi

    Entry nameiCOX2_MYCLE
    AccessioniPrimary (citable) accession number: Q9CCF1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3