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Q9CCF1

- COX2_MYCLE

UniProt

Q9CCF1 - COX2_MYCLE

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Protein

Probable cytochrome c oxidase subunit 2

Gene

ctaC

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity).By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • Cu cationBy similarityNote: Binds a copper A center.By similarity
  • hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi246 – 2461Copper ASequence Analysis
Metal bindingi287 – 2871Copper ASequence Analysis
Metal bindingi291 – 2911Copper ASequence Analysis
Metal bindingi295 – 2951Copper ASequence Analysis

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Gene namesi
Name:ctaC
Ordered Locus Names:ML0875
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML0875.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei63 – 8321HelicalSequence AnalysisAdd
BLAST
Transmembranei110 – 13021HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4242Sequence AnalysisAdd
BLAST
Chaini43 – 353311Probable cytochrome c oxidase subunit 2PRO_0000006056Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272631.ML0875.

Structurei

3D structure databases

ProteinModelPortaliQ9CCF1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1622.
HOGENOMiHOG000245527.
KOiK02275.
OMAiMRELWTW.
OrthoDBiEOG68SVXT.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 2 hits.
SSF81464. SSF81464. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CCF1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTARELVCSQ RVGQGLSRRL RPLVLAVTLG VLVVTLSGCS WSDALAIGWP
60 70 80 90 100
EGITPEAHLN RQLWIGAVVA SLVVGVIVWG LIFWSTIFHR KKTTDTELPR
110 120 130 140 150
QFGYNMPLEL VLTVTPFLII SMLFYFTVIV QDKMLYLAKD PEVVIDVTAF
160 170 180 190 200
QWNWKFGYQR VDFKDGTLTY DGVDPARKKA MVSKPEGKDS HGEELVGAVR
210 220 230 240 250
GLNTEDRAYL NFDKVETLGT TTEIPVLVLP AGKRIEFQLN SADVVHSFWV
260 270 280 290 300
PKFLFKRDVM PNPVANNSVN VFQVEEITKT GAFVGHCAEM CGTYHSMMNF
310 320 330 340 350
EVRVVAPNDF KAYLQQRIDG KTNAEALQVI AQPPLAVTTH PFDTRRGQLT

NSQ
Length:353
Mass (Da):39,521
Last modified:June 1, 2001 - v1
Checksum:iAA6BFCAB69A27A20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583920 Genomic DNA. Translation: CAC31256.1.
PIRiE87018.
RefSeqiNP_301661.1. NC_002677.1.
WP_010907985.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31256; CAC31256; CAC31256.
GeneIDi909877.
KEGGimle:ML0875.
PATRICi18053320. VBIMycLep78757_1605.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583920 Genomic DNA. Translation: CAC31256.1 .
PIRi E87018.
RefSeqi NP_301661.1. NC_002677.1.
WP_010907985.1. NC_002677.1.

3D structure databases

ProteinModelPortali Q9CCF1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272631.ML0875.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC31256 ; CAC31256 ; CAC31256 .
GeneIDi 909877.
KEGGi mle:ML0875.
PATRICi 18053320. VBIMycLep78757_1605.

Organism-specific databases

Lepromai ML0875.

Phylogenomic databases

eggNOGi COG1622.
HOGENOMi HOG000245527.
KOi K02275.
OMAi MRELWTW.
OrthoDBi EOG68SVXT.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 2 hits.
SSF81464. SSF81464. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiCOX2_MYCLE
AccessioniPrimary (citable) accession number: Q9CCF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2001
Last modified: November 26, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3