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Q9CCF1 (COX2_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Gene names
Name:ctaC
Ordered Locus Names:ML0875
OrganismMycobacterium leprae (strain TN) [Complete proteome] [HAMAP]
Taxonomic identifier272631 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length353 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) By similarity.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A By similarity.

Heme group By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 4242 Potential
Chain43 – 353311Probable cytochrome c oxidase subunit 2
PRO_0000006056

Regions

Transmembrane63 – 8321Helical; Potential
Transmembrane110 – 13021Helical; Potential

Sites

Metal binding2461Copper A Potential
Metal binding2871Copper A Potential
Metal binding2911Copper A Potential
Metal binding2951Copper A Potential

Sequences

Sequence LengthMass (Da)Tools
Q9CCF1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: AA6BFCAB69A27A20

FASTA35339,521
        10         20         30         40         50         60 
MTARELVCSQ RVGQGLSRRL RPLVLAVTLG VLVVTLSGCS WSDALAIGWP EGITPEAHLN 

        70         80         90        100        110        120 
RQLWIGAVVA SLVVGVIVWG LIFWSTIFHR KKTTDTELPR QFGYNMPLEL VLTVTPFLII 

       130        140        150        160        170        180 
SMLFYFTVIV QDKMLYLAKD PEVVIDVTAF QWNWKFGYQR VDFKDGTLTY DGVDPARKKA 

       190        200        210        220        230        240 
MVSKPEGKDS HGEELVGAVR GLNTEDRAYL NFDKVETLGT TTEIPVLVLP AGKRIEFQLN 

       250        260        270        280        290        300 
SADVVHSFWV PKFLFKRDVM PNPVANNSVN VFQVEEITKT GAFVGHCAEM CGTYHSMMNF 

       310        320        330        340        350 
EVRVVAPNDF KAYLQQRIDG KTNAEALQVI AQPPLAVTTH PFDTRRGQLT NSQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL583920 Genomic DNA. Translation: CAC31256.1.
PIRE87018.
RefSeqNP_301661.1. NC_002677.1.

3D structure databases

ProteinModelPortalQ9CCF1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272631.ML0875.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC31256; CAC31256; CAC31256.
GeneID909877.
KEGGmle:ML0875.
PATRIC18053320. VBIMycLep78757_1605.

Organism-specific databases

LepromaML0875.
CMRSearch...

Phylogenomic databases

eggNOGCOG1622.
HOGENOMHOG000245527.
KOK02275.
OMAMNFEVRA.
OrthoDBEOG68SVXT.
ProtClustDBCLSK791696.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 2 hits.
SSF81464. SSF81464. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_MYCLE
AccessionPrimary (citable) accession number: Q9CCF1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families