ID   COX4_MYCLE              Reviewed;         139 AA.
AC   Q9CCF0;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   27-MAR-2024, entry version 97.
DE   RecName: Full=Probable cytochrome c oxidase polypeptide 4;
DE            EC=7.1.1.9;
DE   AltName: Full=Cytochrome aa3 subunit 4;
DE   AltName: Full=Cytochrome c oxidase polypeptide IV;
GN   Name=ctaF; OrderedLocusNames=ML0876;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- FUNCTION: Part of cytochrome c oxidase, its function is unknown.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-
CC         [cytochrome c] + 4 H(+)(out) + 2 H2O; Xref=Rhea:RHEA:11436,
CC         Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033,
CC         ChEBI:CHEBI:29034; EC=7.1.1.9;
CC   -!- SUBUNIT: Associates with subunits I, II and III to form cytochrome c
CC       oxidase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cytochrome c oxidase bacterial subunit CtaF
CC       family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL583920; CAC31257.1; -; Genomic_DNA.
DR   PIR; F87018; F87018.
DR   RefSeq; NP_301662.1; NC_002677.1.
DR   RefSeq; WP_010907986.1; NC_002677.1.
DR   AlphaFoldDB; Q9CCF0; -.
DR   SMR; Q9CCF0; -.
DR   STRING; 272631.gene:17574702; -.
DR   KEGG; mle:ML0876; -.
DR   PATRIC; fig|272631.5.peg.1606; -.
DR   Leproma; ML0876; -.
DR   eggNOG; ENOG5032TTI; Bacteria.
DR   HOGENOM; CLU_145919_0_0_11; -.
DR   OrthoDB; 5244617at2; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR021050; Cyt_c_oxidase_su4_actinobac.
DR   Pfam; PF12270; Cyt_c_ox_IV; 1.
DR   PIRSF; PIRSF017385; CtaF; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Translocase; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..139
FT                   /note="Probable cytochrome c oxidase polypeptide 4"
FT                   /id="PRO_0000220017"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   139 AA;  14970 MW;  0CE348456D833A01 CRC64;
     MHIEARLFEF VAVFFVIMAV LYGVLTSMFA TGGVDWVGTT ALALTGGLAL IVATFFRFVA
     RRLDIRPEDY EGAEISDGAG ELGFFSPHSW WPVLVALSGS VAAVGIALWL PWLIVAGVVF
     VLASAAGLVF EYYVGPEKH
//