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Q9CCF0

- COX4_MYCLE

UniProt

Q9CCF0 - COX4_MYCLE

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Protein
Probable cytochrome c oxidase polypeptide 4
Gene
ctaF, ML0876
Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Part of cytochrome c oxidase, its function is unknown By similarity.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Oxidoreductase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable cytochrome c oxidase polypeptide 4 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome aa3 subunit 4
    Cytochrome c oxidase polypeptide IV
    Gene namesi
    Name:ctaF
    Ordered Locus Names:ML0876
    OrganismiMycobacterium leprae (strain TN)
    Taxonomic identifieri272631 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000806: Chromosome

    Organism-specific databases

    LepromaiML0876.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei10 – 3021Helical; Reviewed prediction
    Add
    BLAST
    Transmembranei36 – 5621Helical; Reviewed prediction
    Add
    BLAST
    Transmembranei79 – 9921Helical; Reviewed prediction
    Add
    BLAST
    Transmembranei101 – 12121Helical; Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 139139Probable cytochrome c oxidase polypeptide 4
    PRO_0000220017Add
    BLAST

    Interactioni

    Subunit structurei

    Associates with subunits I, II and III to form cytochrome c oxidase By similarity.

    Protein-protein interaction databases

    STRINGi272631.ML0876.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CCF0.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG07397.
    HOGENOMiHOG000237887.
    OMAiGTYFRFV.
    OrthoDBiEOG63FW2X.

    Family and domain databases

    InterProiIPR021050. Cyt_c_oxidase_su4_actinobac.
    [Graphical view]
    PfamiPF12270. Cyt_c_ox_IV. 1 hit.
    [Graphical view]
    PIRSFiPIRSF017385. CtaF. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9CCF0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHIEARLFEF VAVFFVIMAV LYGVLTSMFA TGGVDWVGTT ALALTGGLAL    50
    IVATFFRFVA RRLDIRPEDY EGAEISDGAG ELGFFSPHSW WPVLVALSGS 100
    VAAVGIALWL PWLIVAGVVF VLASAAGLVF EYYVGPEKH 139
    Length:139
    Mass (Da):14,970
    Last modified:June 1, 2001 - v1
    Checksum:i0CE348456D833A01
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL583920 Genomic DNA. Translation: CAC31257.1.
    PIRiF87018.
    RefSeqiNP_301662.1. NC_002677.1.
    WP_010907986.1. NC_002677.1.

    Genome annotation databases

    EnsemblBacteriaiCAC31257; CAC31257; CAC31257.
    GeneIDi909880.
    KEGGimle:ML0876.
    PATRICi18053322. VBIMycLep78757_1606.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL583920 Genomic DNA. Translation: CAC31257.1 .
    PIRi F87018.
    RefSeqi NP_301662.1. NC_002677.1.
    WP_010907986.1. NC_002677.1.

    3D structure databases

    ProteinModelPortali Q9CCF0.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 272631.ML0876.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC31257 ; CAC31257 ; CAC31257 .
    GeneIDi 909880.
    KEGGi mle:ML0876.
    PATRICi 18053322. VBIMycLep78757_1606.

    Organism-specific databases

    Lepromai ML0876.

    Phylogenomic databases

    eggNOGi NOG07397.
    HOGENOMi HOG000237887.
    OMAi GTYFRFV.
    OrthoDBi EOG63FW2X.

    Family and domain databases

    InterProi IPR021050. Cyt_c_oxidase_su4_actinobac.
    [Graphical view ]
    Pfami PF12270. Cyt_c_ox_IV. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF017385. CtaF. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TN.

    Entry informationi

    Entry nameiCOX4_MYCLE
    AccessioniPrimary (citable) accession number: Q9CCF0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: June 1, 2001
    Last modified: September 3, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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