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Protein

Glucose-1-phosphate adenylyltransferase

Gene

glgC

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans.By similarity

Catalytic activityi

ATP + alpha-D-glucose 1-phosphate = diphosphate + ADP-glucose.

Pathwayi: glycogen biosynthesis

This protein is involved in the pathway glycogen biosynthesis, which is part of Glycan biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycogen biosynthesis and in Glycan biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Carbohydrate metabolism, Glycogen biosynthesis, Glycogen metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00164.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-1-phosphate adenylyltransferase (EC:2.7.7.27)
Alternative name(s):
ADP-glucose pyrophosphorylase
Short name:
ADPGlc PPase
ADP-glucose synthase
Gene namesi
Name:glgC
Ordered Locus Names:ML1069
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1069.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404Glucose-1-phosphate adenylyltransferasePRO_0000195306Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272631.ML1069.

Structurei

3D structure databases

ProteinModelPortaliQ9CCA8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105EFR. Bacteria.
COG0448. LUCA.
HOGENOMiHOG000278607.
KOiK00975.
OMAiFGCIDSD.
OrthoDBiPOG091H09L2.

Family and domain databases

Gene3Di3.90.550.10. 2 hits.
HAMAPiMF_00624. GlgC. 1 hit.
InterProiIPR005836. ADP_Glu_pyroP_CS.
IPR011831. GlgC.
IPR023049. GlgC_bac.
IPR005835. NTP_transferase_dom.
IPR029044. Nucleotide-diphossugar_trans.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PfamiPF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF51161. SSF51161. 1 hit.
SSF53448. SSF53448. 2 hits.
TIGRFAMsiTIGR02091. glgC. 1 hit.
PROSITEiPS00808. ADP_GLC_PYROPHOSPH_1. 1 hit.
PS00809. ADP_GLC_PYROPHOSPH_2. 1 hit.
PS00810. ADP_GLC_PYROPHOSPH_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CCA8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREVPQVLGI VLAGGEGKRL YPLTADRAKP AVPFGGAYRL VDFVLSNLVN
60 70 80 90 100
ARYLRICVLT QYKSHSLDRH ISQNWRLSGL AGEYITPVPA QQRFGPHWYT
110 120 130 140 150
GSADAIYQSL NLIYDEDPDY LVVFGADHVY RMDPEQMLRF HIGSGAGATV
160 170 180 190 200
AGIRVPRSDA TAFGCIDADD SGRIRRFTEK PLKPPGTPDD PDKTFVSMGN
210 220 230 240 250
YIFTTKVLVD AIRADADDDH SYHDMGGDIL PRLVDGGMAA VYDFSQNEVP
260 270 280 290 300
GATDWDRAYW RDVGTLDAFY DAHMDLVSLR PVFNLYNKRW PIRGESENLA
310 320 330 340 350
PAKFVNGGSV QESVVGAGSI ISAASVRNSV LSSNVVVDNG AIVEGSVIMP
360 370 380 390 400
GARVGRGAVI RHAILDKNVV VGPGEMVGVD PERDREHFAI SAGGVVVVGK

GVWI
Length:404
Mass (Da):43,947
Last modified:June 1, 2001 - v1
Checksum:i3218709C2A0DCEF3
GO

Sequence cautioni

The sequence AAA62917 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15180 Genomic DNA. Translation: AAA62917.1. Different initiation.
AL583920 Genomic DNA. Translation: CAC31450.1.
PIRiG87042.
T45186.
RefSeqiNP_301786.1. NC_002677.1.
WP_010908110.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31450; CAC31450; CAC31450.
GeneIDi910156.
KEGGimle:ML1069.
PATRICi18053947. VBIMycLep78757_1918.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15180 Genomic DNA. Translation: AAA62917.1. Different initiation.
AL583920 Genomic DNA. Translation: CAC31450.1.
PIRiG87042.
T45186.
RefSeqiNP_301786.1. NC_002677.1.
WP_010908110.1. NC_002677.1.

3D structure databases

ProteinModelPortaliQ9CCA8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML1069.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC31450; CAC31450; CAC31450.
GeneIDi910156.
KEGGimle:ML1069.
PATRICi18053947. VBIMycLep78757_1918.

Organism-specific databases

LepromaiML1069.

Phylogenomic databases

eggNOGiENOG4105EFR. Bacteria.
COG0448. LUCA.
HOGENOMiHOG000278607.
KOiK00975.
OMAiFGCIDSD.
OrthoDBiPOG091H09L2.

Enzyme and pathway databases

UniPathwayiUPA00164.

Family and domain databases

Gene3Di3.90.550.10. 2 hits.
HAMAPiMF_00624. GlgC. 1 hit.
InterProiIPR005836. ADP_Glu_pyroP_CS.
IPR011831. GlgC.
IPR023049. GlgC_bac.
IPR005835. NTP_transferase_dom.
IPR029044. Nucleotide-diphossugar_trans.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PfamiPF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF51161. SSF51161. 1 hit.
SSF53448. SSF53448. 2 hits.
TIGRFAMsiTIGR02091. glgC. 1 hit.
PROSITEiPS00808. ADP_GLC_PYROPHOSPH_1. 1 hit.
PS00809. ADP_GLC_PYROPHOSPH_2. 1 hit.
PS00810. ADP_GLC_PYROPHOSPH_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLGC_MYCLE
AccessioniPrimary (citable) accession number: Q9CCA8
Secondary accession number(s): Q49961
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.