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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathway:iL-histidine biosynthesis

This protein is involved in step 9 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG)
  2. Phosphoribosyl-ATP pyrophosphatase (hisE)
  3. Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. Phosphoribosyl isomerase A (priA)
  5. Imidazole glycerol phosphate synthase subunit HisH (hisH), Imidazole glycerol phosphate synthase subunit HisF (hisF)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei136 – 1361NADBy similarity
Binding sitei204 – 2041NADBy similarity
Binding sitei232 – 2321NADBy similarity
Binding sitei255 – 2551SubstrateBy similarity
Metal bindingi277 – 2771ZincBy similarity
Binding sitei277 – 2771SubstrateBy similarity
Metal bindingi280 – 2801ZincBy similarity
Binding sitei280 – 2801SubstrateBy similarity
Active sitei346 – 3461Proton acceptorBy similarity
Active sitei347 – 3471Proton acceptorBy similarity
Binding sitei347 – 3471SubstrateBy similarity
Metal bindingi380 – 3801ZincBy similarity
Binding sitei380 – 3801SubstrateBy similarity
Binding sitei434 – 4341SubstrateBy similarity
Metal bindingi439 – 4391ZincBy similarity
Binding sitei439 – 4391SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:ML1257
ORF Names:MLCB1610.20
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
ProteomesiUP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1257.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 449449Histidinol dehydrogenasePRO_0000135796Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272631.ML1257.

Structurei

3D structure databases

ProteinModelPortaliQ9CC57.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiLSVQSFL.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CC57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSITPPFLLA CIDLRGAELT ATQLRATLPR GGADVEAVLP TVWPIVQAVA
60 70 80 90 100
ECGADAALEF GALFDGVRPP TVRVPDAALD AALAGLDPDV RDALQVMIER
110 120 130 140 150
TRVVHADQRR TDVTTALGPG ATVTERWVPV ERVGLYVPGG NAVYPSSVVM
160 170 180 190 200
NVVPAQTAGV DSLVVASPPQ FTSGGRFHGL PHPTILAAAR LLGVDEVWAV
210 220 230 240 250
GGAQAVALLA YGGTDSDDCE LAPVDMITGP GNIYVTAAKR LCRSRVGIDG
260 270 280 290 300
EAGPTEIAIL ADHTADPAHV AADMISQAEH DEMAASVLVT PSTDLADATD
310 320 330 340 350
AELAAQLRTT VHRKRVVAAL GGRQSAIILV DDLEAGVKVV NLYAAEHLEI
360 370 380 390 400
QTAEASRVAS RIRCAGAIFV GPWAPVSLGD YCAGSNHVLP TAGFARHSGG
410 420 430 440
LSVQTFLRGI HVVNYTKTAL KDISGHVITL AKAEDLPAHG EAVRRRFAR
Length:449
Mass (Da):46,828
Last modified:June 1, 2001 - v1
Checksum:i241D7CC6DF3AF171
GO

Sequence cautioni

The sequence CAB43166.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049913 Genomic DNA. Translation: CAB43166.1. Different initiation.
AL583921 Genomic DNA. Translation: CAC31638.1.
PIRiC87066.
T45246.
RefSeqiNP_301906.1. NC_002677.1.
WP_010908227.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31638; CAC31638; CAC31638.
GeneIDi910363.
KEGGimle:ML1257.
PATRICi18054758. VBIMycLep78757_2318.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049913 Genomic DNA. Translation: CAB43166.1. Different initiation.
AL583921 Genomic DNA. Translation: CAC31638.1.
PIRiC87066.
T45246.
RefSeqiNP_301906.1. NC_002677.1.
WP_010908227.1. NC_002677.1.

3D structure databases

ProteinModelPortaliQ9CC57.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML1257.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC31638; CAC31638; CAC31638.
GeneIDi910363.
KEGGimle:ML1257.
PATRICi18054758. VBIMycLep78757_2318.

Organism-specific databases

LepromaiML1257.

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiLSVQSFL.
OrthoDBiEOG6CVVCR.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiHISX_MYCLE
AccessioniPrimary (citable) accession number: Q9CC57
Secondary accession number(s): Q9X7B7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: June 1, 2001
Last modified: June 24, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.