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Q9CC57

- HISX_MYCLE

UniProt

Q9CC57 - HISX_MYCLE

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Protein

Histidinol dehydrogenase

Gene
hisD, ML1257, MLCB1610.20
Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei136 – 1361NAD By similarity
Binding sitei204 – 2041NAD By similarity
Binding sitei232 – 2321NAD By similarity
Binding sitei255 – 2551Substrate By similarity
Metal bindingi277 – 2771Zinc By similarity
Binding sitei277 – 2771Substrate By similarity
Metal bindingi280 – 2801Zinc By similarity
Binding sitei280 – 2801Substrate By similarity
Active sitei346 – 3461Proton acceptor By similarity
Active sitei347 – 3471Proton acceptor By similarity
Binding sitei347 – 3471Substrate By similarity
Metal bindingi380 – 3801Zinc By similarity
Binding sitei380 – 3801Substrate By similarity
Binding sitei434 – 4341Substrate By similarity
Metal bindingi439 – 4391Zinc By similarity
Binding sitei439 – 4391Substrate By similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:ML1257
ORF Names:MLCB1610.20
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML1257.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 449449Histidinol dehydrogenaseUniRule annotationPRO_0000135796Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272631.ML1257.

Structurei

3D structure databases

ProteinModelPortaliQ9CC57.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CC57-1 [UniParc]FASTAAdd to Basket

« Hide

MSITPPFLLA CIDLRGAELT ATQLRATLPR GGADVEAVLP TVWPIVQAVA    50
ECGADAALEF GALFDGVRPP TVRVPDAALD AALAGLDPDV RDALQVMIER 100
TRVVHADQRR TDVTTALGPG ATVTERWVPV ERVGLYVPGG NAVYPSSVVM 150
NVVPAQTAGV DSLVVASPPQ FTSGGRFHGL PHPTILAAAR LLGVDEVWAV 200
GGAQAVALLA YGGTDSDDCE LAPVDMITGP GNIYVTAAKR LCRSRVGIDG 250
EAGPTEIAIL ADHTADPAHV AADMISQAEH DEMAASVLVT PSTDLADATD 300
AELAAQLRTT VHRKRVVAAL GGRQSAIILV DDLEAGVKVV NLYAAEHLEI 350
QTAEASRVAS RIRCAGAIFV GPWAPVSLGD YCAGSNHVLP TAGFARHSGG 400
LSVQTFLRGI HVVNYTKTAL KDISGHVITL AKAEDLPAHG EAVRRRFAR 449
Length:449
Mass (Da):46,828
Last modified:June 1, 2001 - v1
Checksum:i241D7CC6DF3AF171
GO

Sequence cautioni

The sequence CAB43166.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL049913 Genomic DNA. Translation: CAB43166.1. Different initiation.
AL583921 Genomic DNA. Translation: CAC31638.1.
PIRiC87066.
T45246.
RefSeqiNP_301906.1. NC_002677.1.
WP_010908227.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31638; CAC31638; CAC31638.
GeneIDi910363.
KEGGimle:ML1257.
PATRICi18054758. VBIMycLep78757_2318.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL049913 Genomic DNA. Translation: CAB43166.1 . Different initiation.
AL583921 Genomic DNA. Translation: CAC31638.1 .
PIRi C87066.
T45246.
RefSeqi NP_301906.1. NC_002677.1.
WP_010908227.1. NC_002677.1.

3D structure databases

ProteinModelPortali Q9CC57.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272631.ML1257.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC31638 ; CAC31638 ; CAC31638 .
GeneIDi 910363.
KEGGi mle:ML1257.
PATRICi 18054758. VBIMycLep78757_2318.

Organism-specific databases

Lepromai ML1257.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiHISX_MYCLE
AccessioniPrimary (citable) accession number: Q9CC57
Secondary accession number(s): Q9X7B7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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