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Q9CC57

- HISX_MYCLE

UniProt

Q9CC57 - HISX_MYCLE

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei136 – 1361NADBy similarity
    Binding sitei204 – 2041NADBy similarity
    Binding sitei232 – 2321NADBy similarity
    Binding sitei255 – 2551SubstrateBy similarity
    Metal bindingi277 – 2771ZincBy similarity
    Binding sitei277 – 2771SubstrateBy similarity
    Metal bindingi280 – 2801ZincBy similarity
    Binding sitei280 – 2801SubstrateBy similarity
    Active sitei346 – 3461Proton acceptorBy similarity
    Active sitei347 – 3471Proton acceptorBy similarity
    Binding sitei347 – 3471SubstrateBy similarity
    Metal bindingi380 – 3801ZincBy similarity
    Binding sitei380 – 3801SubstrateBy similarity
    Binding sitei434 – 4341SubstrateBy similarity
    Metal bindingi439 – 4391ZincBy similarity
    Binding sitei439 – 4391SubstrateBy similarity

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenase (EC:1.1.1.23)
    Short name:
    HDH
    Gene namesi
    Name:hisD
    Ordered Locus Names:ML1257
    ORF Names:MLCB1610.20
    OrganismiMycobacterium leprae (strain TN)
    Taxonomic identifieri272631 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000806: Chromosome

    Organism-specific databases

    LepromaiML1257.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 449449Histidinol dehydrogenasePRO_0000135796Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272631.ML1257.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CC57.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiYAAKLCG.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9CC57-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSITPPFLLA CIDLRGAELT ATQLRATLPR GGADVEAVLP TVWPIVQAVA    50
    ECGADAALEF GALFDGVRPP TVRVPDAALD AALAGLDPDV RDALQVMIER 100
    TRVVHADQRR TDVTTALGPG ATVTERWVPV ERVGLYVPGG NAVYPSSVVM 150
    NVVPAQTAGV DSLVVASPPQ FTSGGRFHGL PHPTILAAAR LLGVDEVWAV 200
    GGAQAVALLA YGGTDSDDCE LAPVDMITGP GNIYVTAAKR LCRSRVGIDG 250
    EAGPTEIAIL ADHTADPAHV AADMISQAEH DEMAASVLVT PSTDLADATD 300
    AELAAQLRTT VHRKRVVAAL GGRQSAIILV DDLEAGVKVV NLYAAEHLEI 350
    QTAEASRVAS RIRCAGAIFV GPWAPVSLGD YCAGSNHVLP TAGFARHSGG 400
    LSVQTFLRGI HVVNYTKTAL KDISGHVITL AKAEDLPAHG EAVRRRFAR 449
    Length:449
    Mass (Da):46,828
    Last modified:June 1, 2001 - v1
    Checksum:i241D7CC6DF3AF171
    GO

    Sequence cautioni

    The sequence CAB43166.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL049913 Genomic DNA. Translation: CAB43166.1. Different initiation.
    AL583921 Genomic DNA. Translation: CAC31638.1.
    PIRiC87066.
    T45246.
    RefSeqiNP_301906.1. NC_002677.1.
    WP_010908227.1. NC_002677.1.

    Genome annotation databases

    EnsemblBacteriaiCAC31638; CAC31638; CAC31638.
    GeneIDi910363.
    KEGGimle:ML1257.
    PATRICi18054758. VBIMycLep78757_2318.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL049913 Genomic DNA. Translation: CAB43166.1 . Different initiation.
    AL583921 Genomic DNA. Translation: CAC31638.1 .
    PIRi C87066.
    T45246.
    RefSeqi NP_301906.1. NC_002677.1.
    WP_010908227.1. NC_002677.1.

    3D structure databases

    ProteinModelPortali Q9CC57.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272631.ML1257.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC31638 ; CAC31638 ; CAC31638 .
    GeneIDi 910363.
    KEGGi mle:ML1257.
    PATRICi 18054758. VBIMycLep78757_2318.

    Organism-specific databases

    Lepromai ML1257.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi YAAKLCG.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TN.

    Entry informationi

    Entry nameiHISX_MYCLE
    AccessioniPrimary (citable) accession number: Q9CC57
    Secondary accession number(s): Q9X7B7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 14, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3