Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9CC56

- HIS4_MYCLE

UniProt

Q9CC56 - HIS4_MYCLE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Phosphoribosyl isomerase A

Gene

priA

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in both the histidine and tryptophan biosynthetic pathways.By similarity

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide.
N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei10 – 101Proton acceptorBy similarity
Active sitei129 – 1291Proton donorBy similarity

GO - Molecular functioni

  1. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Source: UniProtKB-HAMAP
  2. phosphoribosylanthranilate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
  2. tryptophan biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Histidine biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00031; UER00009.
UPA00035; UER00042.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosyl isomerase A
Alternative name(s):
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (EC:5.3.1.16)
N-(5'-phosphoribosyl)anthranilate isomerase (EC:5.3.1.24)
Short name:
PRAI
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
Gene namesi
Name:priA
Synonyms:hisA
Ordered Locus Names:ML1261
ORF Names:MLCB1610.24
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML1261.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 244244Phosphoribosyl isomerase APRO_0000142083Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272631.ML1261.

Structurei

3D structure databases

ProteinModelPortaliQ9CC56.
SMRiQ9CC56. Positions 3-239.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HisA/HisF family.Curated

Phylogenomic databases

eggNOGiCOG0106.
HOGENOMiHOG000224614.
KOiK01814.
K01817.
OMAiQRDYGSD.
OrthoDBiEOG6H1Q3W.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01014. HisA.
InterProiIPR013785. Aldolase_TIM.
IPR006062. His_biosynth.
IPR010188. HisA_TrpF.
IPR023016. Isoase_HisA.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00977. His_biosynth. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01919. hisA-trpF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CC56 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLILLPAVD VVEGRAVRLV QGKAGSENDY GSALDAALCW QRDGADWIHL
60 70 80 90 100
VDLDAAFGRG SNRELLSEMV GKLDVQVELS GGIRDDDSLN AALATGCARV
110 120 130 140 150
NLGTAACENP HWCAQVIAEH GDKIAVGLDV QIVDGQHRLR GRGWETDGGD
160 170 180 190 200
LWDVLENLDR QGCSRFIVTD VTKDGTLDGP NLDLLASVSD RTNVPVIASG
210 220 230 240
GVSSLDDLRA IAKFTERGIE GAIVGKALYA ERFTLPQALA VVRM
Length:244
Mass (Da):26,003
Last modified:May 2, 2002 - v2
Checksum:iCABD3D38309800E8
GO

Sequence cautioni

The sequence CAB43170.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAC31642.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL049913 Genomic DNA. Translation: CAB43170.1. Different initiation.
AL583921 Genomic DNA. Translation: CAC31642.1. Different initiation.
PIRiG87066.
T45250.
RefSeqiNP_301910.1. NC_002677.1.
WP_010908231.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31642; CAC31642; CAC31642.
GeneIDi910372.
KEGGimle:ML1261.
PATRICi18054766. VBIMycLep78757_2322.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL049913 Genomic DNA. Translation: CAB43170.1 . Different initiation.
AL583921 Genomic DNA. Translation: CAC31642.1 . Different initiation.
PIRi G87066.
T45250.
RefSeqi NP_301910.1. NC_002677.1.
WP_010908231.1. NC_002677.1.

3D structure databases

ProteinModelPortali Q9CC56.
SMRi Q9CC56. Positions 3-239.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272631.ML1261.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC31642 ; CAC31642 ; CAC31642 .
GeneIDi 910372.
KEGGi mle:ML1261.
PATRICi 18054766. VBIMycLep78757_2322.

Organism-specific databases

Lepromai ML1261.

Phylogenomic databases

eggNOGi COG0106.
HOGENOMi HOG000224614.
KOi K01814.
K01817.
OMAi QRDYGSD.
OrthoDBi EOG6H1Q3W.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00009 .
UPA00035 ; UER00042 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01014. HisA.
InterProi IPR013785. Aldolase_TIM.
IPR006062. His_biosynth.
IPR010188. HisA_TrpF.
IPR023016. Isoase_HisA.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00977. His_biosynth. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01919. hisA-trpF. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiHIS4_MYCLE
AccessioniPrimary (citable) accession number: Q9CC56
Secondary accession number(s): Q9X7C1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 2, 2002
Last modified: October 29, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3