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Q9CC56 (HIS4_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoribosyl isomerase A
Alternative name(s):
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
EC=5.3.1.16
N-(5'-phosphoribosyl)anthranilate isomerase
Short name=PRAI
EC=5.3.1.24
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
Gene names
Name:priA
Synonyms:hisA
Ordered Locus Names:ML1261
ORF Names:MLCB1610.24
OrganismMycobacterium leprae (strain TN) [Complete proteome] [HAMAP]
Taxonomic identifier272631 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length244 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in both the histidine and tryptophan biosynthetic pathways By similarity. HAMAP-Rule MF_01014

Catalytic activity

1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_01014

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate. HAMAP-Rule MF_01014

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9. HAMAP-Rule MF_01014

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5. HAMAP-Rule MF_01014

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01014.

Sequence similarities

Belongs to the HisA/HisF family.

Sequence caution

The sequence CAB43170.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAC31642.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 244244Phosphoribosyl isomerase A HAMAP-Rule MF_01014
PRO_0000142083

Sites

Active site101Proton acceptor By similarity
Active site1291Proton donor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9CC56 [UniParc].

Last modified May 2, 2002. Version 2.
Checksum: CABD3D38309800E8

FASTA24426,003
        10         20         30         40         50         60 
MSLILLPAVD VVEGRAVRLV QGKAGSENDY GSALDAALCW QRDGADWIHL VDLDAAFGRG 

        70         80         90        100        110        120 
SNRELLSEMV GKLDVQVELS GGIRDDDSLN AALATGCARV NLGTAACENP HWCAQVIAEH 

       130        140        150        160        170        180 
GDKIAVGLDV QIVDGQHRLR GRGWETDGGD LWDVLENLDR QGCSRFIVTD VTKDGTLDGP 

       190        200        210        220        230        240 
NLDLLASVSD RTNVPVIASG GVSSLDDLRA IAKFTERGIE GAIVGKALYA ERFTLPQALA 


VVRM 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL049913 Genomic DNA. Translation: CAB43170.1. Different initiation.
AL583921 Genomic DNA. Translation: CAC31642.1. Different initiation.
PIRG87066.
T45250.
RefSeqNP_301910.1. NC_002677.1.

3D structure databases

ProteinModelPortalQ9CC56.
SMRQ9CC56. Positions 3-239.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272631.ML1261.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC31642; CAC31642; CAC31642.
GeneID910372.
KEGGmle:ML1261.
PATRIC18054766. VBIMycLep78757_2322.

Organism-specific databases

LepromaML1261.
CMRSearch...

Phylogenomic databases

eggNOGCOG0106.
HOGENOMHOG000224614.
KOK01814.
K01817.
OMACARYVVT.
OrthoDBEOG6H1Q3W.
ProtClustDBPRK14024.

Enzyme and pathway databases

UniPathwayUPA00031; UER00009.
UPA00035; UER00042.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01014. HisA.
InterProIPR013785. Aldolase_TIM.
IPR006062. His_biosynth.
IPR010188. HisA_TrpF.
IPR023016. Isoase_HisA.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00977. His_biosynth. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01919. hisA-trpF. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHIS4_MYCLE
AccessionPrimary (citable) accession number: Q9CC56
Secondary accession number(s): Q9X7C1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 2, 2002
Last modified: February 19, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways