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Q9CC56

- HIS4_MYCLE

UniProt

Q9CC56 - HIS4_MYCLE

Protein

Phosphoribosyl isomerase A

Gene

priA

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 2 (02 May 2002)
      Previous versions | rss
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    • Comment

    Functioni

    Involved in both the histidine and tryptophan biosynthetic pathways.By similarity

    Catalytic activityi

    1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide.
    N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei10 – 101Proton acceptorBy similarity
    Active sitei129 – 1291Proton donorBy similarity

    GO - Molecular functioni

    1. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Source: UniProtKB-HAMAP
    2. phosphoribosylanthranilate isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP
    2. tryptophan biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Histidine biosynthesis, Tryptophan biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00031; UER00009.
    UPA00035; UER00042.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosyl isomerase A
    Alternative name(s):
    1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (EC:5.3.1.16)
    N-(5'-phosphoribosyl)anthranilate isomerase (EC:5.3.1.24)
    Short name:
    PRAI
    Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
    Gene namesi
    Name:priA
    Synonyms:hisA
    Ordered Locus Names:ML1261
    ORF Names:MLCB1610.24
    OrganismiMycobacterium leprae (strain TN)
    Taxonomic identifieri272631 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000806: Chromosome

    Organism-specific databases

    LepromaiML1261.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 244244Phosphoribosyl isomerase APRO_0000142083Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272631.ML1261.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CC56.
    SMRiQ9CC56. Positions 3-239.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HisA/HisF family.Curated

    Phylogenomic databases

    eggNOGiCOG0106.
    HOGENOMiHOG000224614.
    KOiK01814.
    K01817.
    OMAiQRDYGSD.
    OrthoDBiEOG6H1Q3W.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01014. HisA.
    InterProiIPR013785. Aldolase_TIM.
    IPR006062. His_biosynth.
    IPR010188. HisA_TrpF.
    IPR023016. Isoase_HisA.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00977. His_biosynth. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR01919. hisA-trpF. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9CC56-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLILLPAVD VVEGRAVRLV QGKAGSENDY GSALDAALCW QRDGADWIHL    50
    VDLDAAFGRG SNRELLSEMV GKLDVQVELS GGIRDDDSLN AALATGCARV 100
    NLGTAACENP HWCAQVIAEH GDKIAVGLDV QIVDGQHRLR GRGWETDGGD 150
    LWDVLENLDR QGCSRFIVTD VTKDGTLDGP NLDLLASVSD RTNVPVIASG 200
    GVSSLDDLRA IAKFTERGIE GAIVGKALYA ERFTLPQALA VVRM 244
    Length:244
    Mass (Da):26,003
    Last modified:May 2, 2002 - v2
    Checksum:iCABD3D38309800E8
    GO

    Sequence cautioni

    The sequence CAB43170.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAC31642.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL049913 Genomic DNA. Translation: CAB43170.1. Different initiation.
    AL583921 Genomic DNA. Translation: CAC31642.1. Different initiation.
    PIRiG87066.
    T45250.
    RefSeqiNP_301910.1. NC_002677.1.
    WP_010908231.1. NC_002677.1.

    Genome annotation databases

    EnsemblBacteriaiCAC31642; CAC31642; CAC31642.
    GeneIDi910372.
    KEGGimle:ML1261.
    PATRICi18054766. VBIMycLep78757_2322.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL049913 Genomic DNA. Translation: CAB43170.1 . Different initiation.
    AL583921 Genomic DNA. Translation: CAC31642.1 . Different initiation.
    PIRi G87066.
    T45250.
    RefSeqi NP_301910.1. NC_002677.1.
    WP_010908231.1. NC_002677.1.

    3D structure databases

    ProteinModelPortali Q9CC56.
    SMRi Q9CC56. Positions 3-239.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272631.ML1261.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC31642 ; CAC31642 ; CAC31642 .
    GeneIDi 910372.
    KEGGi mle:ML1261.
    PATRICi 18054766. VBIMycLep78757_2322.

    Organism-specific databases

    Lepromai ML1261.

    Phylogenomic databases

    eggNOGi COG0106.
    HOGENOMi HOG000224614.
    KOi K01814.
    K01817.
    OMAi QRDYGSD.
    OrthoDBi EOG6H1Q3W.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00009 .
    UPA00035 ; UER00042 .

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01014. HisA.
    InterProi IPR013785. Aldolase_TIM.
    IPR006062. His_biosynth.
    IPR010188. HisA_TrpF.
    IPR023016. Isoase_HisA.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00977. His_biosynth. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR01919. hisA-trpF. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TN.

    Entry informationi

    Entry nameiHIS4_MYCLE
    AccessioniPrimary (citable) accession number: Q9CC56
    Secondary accession number(s): Q9X7C1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2002
    Last sequence update: May 2, 2002
    Last modified: October 1, 2014
    This is version 87 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3